CAS: 708273-57-8; 4-Hydroxy-4-(6-Methoxypyridin-3-yl)Cyclohexan-1-One

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1600498-52-9 103319-09-1 1145688-60-3

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8-(6-methoxy-pyridin-3-yl)-1,4-dioxa-spiro[4.5]decan-8-ol 2-methoxy-5-bromopyridine cyclohexanedione monoethylene ketal 4-(6-Methoxy-pyridin-3-yl)-cyclohex-3-enone (1-(4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)-3-(methoxymethyl)pyrrolidin-3-yl)(3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)methanone N-(2-((R)-1-(trans-4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide bismethanesulfonate

📜5-溴-2-甲氧基吡啶置于盐酸,正丁基锂,水体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 2.16H,反应生成 4-羟基-4-(6-甲氧基吡啶-3-基)环己酮
参考文献:Discovery Of Incb3284,A Potent,Selective,And Orally Bioavailable Hccr2 Antagonist
标题:Discovery Of Incb3284,A Potent,Selective,And Orally Bioavailable Hccr2 Antagonist
摘要:We Report The Identification Of 13 (Incb3284) As A Potent Human Ccr2 (Hccr2) Antagonist. Incb3284 Exhibited An Ic50 Of 3.7 Nm In Antagonism Of Monocyte Chemoattractant Protein-1 Binding To Hccr2,An Ic50 Of 4.7 Nm In Antagonism Of Chemotaxis Activity,An Ic50 Of 84 Mu M In Inhibition Of The Herg Potassium Current,A Free Fraction Of 58% In Protein Binding,High Selectivity Over Other Chemokine Receptors And G-Protein-Coupled Receptors,And Acceptable Oral Bioavailability In Rodents And Primates. In Human Clinical Trials,Incb3284 Exhibited A Pharmacokinetic Profile Suitable For Once-A-Day Dosing (T-1/2 = 15 H).
DOI:10.1021/ml200030Q