CAS: 685-87-0; Diethyl 2-Bromomalonate

相似化合物

2065-75-0 7691-28-3 29263-94-3

上下游产品

brom°Cyane diethyl malonate diethyl dibromomalonate ethyl methyl malonatediethyl 2-phthalimidomalonate H-furo[2,3-h]chromene-8-carboxylic acid ethyl ester4-oxo-3-phenyl-4H-furo[2,3-h]chromene-8-carboxylic acid ethyl ester H-furo[2,3-h]chromene-8-carboxylic acid ethyl ester2-methyl-4-oxo-3-phenyl-4H-furo[2,3-h]chromene-8-carboxylic acid ethyl ester H-furo[2,3-h]chromene-8-carboxylic acid ethyl ester3-methoxy-4-oxo-2-phenyl-4H-furo[2,3-h]chromene-8-carboxylic acid ethyl ester

丙二酸二乙酯置于monobromoisocynaurate体系中,用 邻二氯苯 作为反应溶剂,化学反应 24.0H,反应生成 溴代丙二酸二乙酯
参考文献:通过单溴异氰尿酸钠(smbi)进行溴化.
标题:通过单溴异氰尿酸钠(smbi)进行溴化.
摘要:用一溴异氰尿酸钠(smbi)1溴化具有激活和失活取代基的各种芳族化合物,将二乙醚,二乙醚-甲磺酸,三氟乙酸或硫酸用作溶剂.因此,硝基苯在硫酸中方便地被溴化,苯在乙醚-甲磺酸中很容易被单溴化,并且苯酚在回流条件下在温和条件下在邻位选择性溴化.对于容易质子化的取代基,在与1的反应中可以使用三氟乙酸作作为反应溶剂,相反,Nbs在三氟乙酸中无效.相对于nbs,这提供了一种更好的试剂.除芳族化合物外,烯烃,酮和酯也用1溴化.
DOI:10.1039/b302738D

专利信息

专利号:US-10294196-B2
优先权日:2015-11-18
标题:Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives
发明人：XU SHENG; XU YIHUI
权利人:FMC CORP
摘要:A process for the synthesis of 1,3-diethyl 2-(2-methylhydrazinylidene)propanedioate comprising the step of: reacting 2-halosubstituted diethyl malonate or mixtures of 2-halo-substituted diethyl malonates with methylhydrazine or the salt thereof in the presence of an acid catalyst is disclosed. 1,3-diethyl 2-(2-methylhydrazinylidene)propanedioate is an intermediate useful for preparing 1,3,4-triazines.

专利号:US-6538153-B1
优先权日:2001-09-25
标 题:Method of synthesis of water soluble fullerene polyacids using a macrocyclic malonate reactant
发明人：HIRSCH ANDREAS; REUTHER UWE
权利人:SIXTY INC C
摘要:A method for synthesizing compounds of the formulawhere C60 is a C60 fullerene. The method comprises the steps of forming a macrocyclic malonate compound of the formulawhere each Z is the same or different and is a straight-chain or branched-chain aliphatic radical having from 1-30 carbon atoms which may be unsubstituted or monosubstituted or polysubstituted by identical or different substitutents, in which radicals up to every third CH2 unit can be replaced by O or NR where R is alkyl having 1-20 carbon atoms or a chain containing unsubstituted or substituted aryl or other cyclic groups and n is an integer from 2 to 10; reacting said macrocyclic malonate compound with C60 to form an adduct of the formulawhere the Z radicals are linked together to form said macrocycle adduct; and hydrolyzing said macrocycle adduct to form a compound of the formula

专利号:US-2006047167-A1
优先权日:2004-09-02
标题 :Method of synthesis of water soluble fullerene polyacids using a malonate reactant
发明人：HIRSCH ANDREAS; BEUERLE FLORIAN; CHRONAKIS NIKOS
权利人:HIRSCH ANDREAS; BEUERLE FLORIAN; CHRONAKIS NIKOS
摘要:In one embodiment, the present invention is directed to a method for synthesizing compounds of the formula n n nwhere C m is a fullerene having m carbon atoms, the method comprising the steps of forming a linear malonate compound of the formula n n nwhere each Z is the same or different and is a straight-chain or branched-chain aliphatic radical having from 1-30 carbon atoms which may be unsubstituted or monosubstituted or polysubstituted by identical or different substitutents, in which radicals up to every third —CH 2 — unit can be replaced by O or NR″, n is an integer from 2 to 10, and the unfilled valences of the first and nth malonate groups are filled with bonds to hydrogen, a hydrocarbon group or substituted hydrocarbon group having 1-20 carbon atoms, or a chain containing unsubstituted or substituted aryl or other cyclic groups; or (ii) a branched malonate compound of the formula n n nwhere Z′ is an aliphatic radical having from 1-30 carbon atoms which may be unsubstituted or monosubstituted or polysubstituted by identical or different substitutents, in which radicals up to every third —CH 2 — unit can be replaced by O or NR″; and n is an integer from 2 to 10; n n reacting said malonate compound with C m to form an adduct of the formula n neach Z is bonded to both one carboxylate group of a first malonate moiety and one carboxylate group of a second malonate moiety and the unfilled valences of the first and nth malonate groups are filled with bonds to hydrogen, a hydrocarbon group or substituted hydrocarbon group having 1-20 carbon atoms, or a chain containing unsubstituted or substituted aryl or other cyclic groups; and hydrolyzing said adduct to form the compound.

专利号:WO-2006028776-A1
优先权日:2004-09-02
标题:Method of synthesis of water soluble fullerene polyacids using a malonate reactant
发明人：HIRSCH ANDREAS
权利人:SIXTY INC C; HIRSCH ANDREAS
摘要:A method for synthesizing compounds of the formula (I) where Cm is a fullerene having m carbon atoms and each R is independently -H or -Râ€? COOH where R is alkyl having 1-20 carbon atoms, substituted alkyl having 1-20 carbon atoms, alkenyl having 1-20 carbon atoms, substituted alkenyl having 1-20 carbon atoms, or a chain containing unsubstituted or substituted aryl or other cyclic groups, the method comprising the steps of forming a linear or branched malonate compound and hydrolyzing said adduct to form the compound.

专利号:US-4503252-A
优先权日:1979-09-10
标题:Process for the preparation of serinol and of serinol derivatives, and products obtained therefrom
发明人：FELDER ERNST; BIANCHI SERGIO; BOLLINGER HEINRICH
权利人:EPROVA AG
摘要:A method for the synthesis of serinol and serinol derivatives substituted at the nitrogen atoms by reacting a lower 1,3-dialkoxy-isopropyl halide with ammonia or an amine to form a 1,3-dialkoxy-isopropylamine and then removing the ether groups by heating with a hydrogen halide acid. The method allows the production of serinol and serinol derivatives using inexpensive starting materials in a simple manner and obtaining a high purity product which is free of interfering isomers. Novel compounds obtained by the method which are useful as pharmaceutical intermediates, X-ray contrasting agents and cytostatic or psychopharmacological drugs are also disclosed.

专利号:US-6448412-B1
优先权日:1995-07-31
标题:Methods for the preparation and characterization of multi-substituted fullerenes
发明人：MURPHY RANDALL B; WILSON STEPHEN R; LU QUING
权利人:SPHERE BIOSYSTEMS INC
摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.