CAS: 638-95-9; α-Amyrin

该化合物是一种被归类为多环三叶杆的三叶类化合物,主要存在于各种植物物种中,特别是某些树脂和某些药用植物叶叶中的树脂中,其分子式为C30H50O,具有五环相连的复杂结构. -爱美林因其潜在的药理特性而闻名,包括抗炎,抗氧化剂和抗微生物活动,使其对传统医学和现代制药研究感兴趣.该化合物通常通过从植物来源提取方法分离出来,并可利用气相色谱学和质谱学等技术加以识别.除了生物活动外, -还对艾美林在其他重要自然产品生物合成中的作用进行了研究.

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CAS号863-76-3 Alpha-乙酸香树脂醇酯 | CAS号545-47-1 羽扇豆醇 | CAS号22255-10-3 α-香树脂醇棕榈酸酯 | CAS号638-96-0 URS-12-EN-3-ONE | CAS号555-31-7 异丙醇铝 | CAS号107657-17-0 3β-acetoxy-urse... | CAS号141-52-6 乙醇钠 | CAS号7727-37-9 氮气 | CAS号486-34-0 Naphthalene, 1,...

合成工艺路线路线简述

    📜熊果酸置于吡啶,咪唑,Lithium Aluminium Tetrahydride,四丁基氟化铵,Potassium Carbonate体系中,用 四氢呋喃,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 54.75H,反应生成 α-香树精
    参考文献:改进的可扩展合成α-和β-淀粉状蛋白.
    标题:改进的可扩展合成α-和β-淀粉状蛋白.
    摘要:α-和β-淀粉糊精的合成是从容易获得的起始原料齐墩果酸和熊果酸开始的.该程序允许通过选择性碘化和还原,以极短的可扩展方式制备β-Amyrin.对于α-Amyrin,必须选择不同的合成方法,以提供中到大型的α-Amyrin.
    DOI:10.3390/molecules23071552

    海关参考信息

    专利信息


    专利号:US-8614369-B2
    优先权日:2007-06-25
    标 题:Enzymes involved in triterpene synthesis
    发明人:OSBOURN ANNE; QI XIAOQUAN
    权利人:PLANT BIOSCIENCE LTD
    摘要:This invention relates to isolated polynucleotides encoding enzymes consisting of a carboxypeptidase-like protein, a methyltransferase and a glucosyltransferase, involved in the biosynthesis of β-amyrin-derived triterpenes in plants and seeds. The invention also relates to the construction of recombinant DNA constructs comprising all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to at least one regulatory sequence.

    专利号:US-8257754-B2
    优先权日:2002-10-21
    标 题:Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M
    权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M; METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

    专利号:US-8486457-B2
    优先权日:2002-10-21
    标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
    权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

    专利号:US-8557306-B2
    优先权日:2001-06-20
    标 题 :Compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
    权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

    专利号:CN-111718924-A
    优先权日:2020-06-30
    标 题 :Protein for catalytic synthesis of amyrin, and preparation method and application thereof

    专利号:US-7431948-B2
    优先权日:2001-06-20
    标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
    权利人:METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

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    合成参考文献


    参考文献:10.1248/bpb.22.606
    摘要:TAKASAKI M, KONOSHIMA T, TOKUDA K, MASUDA K, ARAI Y, SHIOJIMA K, AGETA H. Anti-carcinogenic Activity of Taraxacum Plant. II. Biological & Pharmaceutical Bulletin. 1999;22(6):606–10. doi: 10.1248/bpb.22.606.
    参考文献:10.1016/s0367-326x(02)00011-4
    摘要:Ramesh N, Viswanathan MB, Saraswathy A, Balakrishna K, Brindha P, Lakshmanaperumalsamy P. Antimicrobial and phytochemical studies of Swertia corymbosa. Fitoterapia. 2002 Apr;73(2):160–4. doi: 10.1016/s0367-326x(02)00011-4.
    参考文献:10.1021/np0303512
    摘要:Chaturvedula VSP, Schilling JK, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DGI. New Cytotoxic Terpenoids from the Wood of Vepris punctata from the Madagascar Rainforest. J. Nat. Prod. 2004 Apr 17;67(5):895–8. doi: 10.1021/np0303512.
    参考文献:10.1007/s10661-005-9102-8
    摘要:Rushdi AI, Al-Zarban S, Simoneit BRT. Chemical Compositions and Sources of Organic Matter in Fine Particles of Soils and Sands from the Vicinity of Kuwait City. Environmental Monitoring and Assessment. 2006 Jun 07;120(1-3):537–57. doi: 10.1007/s10661-005-9102-8.
    参考文献:10.1186/s12906-015-0888-9
    摘要:de Mendonça ICG, Porto ICCDM, do Nascimento TG, de Souza NS, Oliveira JMDS, Arruda REDS, Mousinho KC, dos Santos AF, Basílio-Júnior ID, Parolia A, Barreto FS. Brazilian red propolis: phytochemical screening, antioxidant activity and effect against cancer cells. BMC Complementary Medicine and Therapies. 2015 Oct 14;15(1):357. doi: 10.1186/s12906-015-0888-9.
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