CAS: 630-94-4; (±)-Corynoxeine
该化合物是一种自然产生的藻类,主要来自昆虫的植物物种,通常称为猫爪,其特征是复杂的分子结构,包括多种环和有助于其生物活动的功能组.科罗新辛表现出一系列的药理特性,包括抗炎,止痛和...
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- 产品信息参考
- InChIKey: MUVGVMUWMAGNSY-KAXDATADSA-N
- MUVGVMUWMAGNSY-VAUYTDFQNA-N
- 计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数5.0
物理性质
MSDS等安全信息
- 警示词warning
- 危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
- 防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
- 危险品标志T+
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
上下游产品
CAS号61-54-1 色胺 | CAS号1443767-65-4 tert-butyl 2,5-... | CAS号76-66-4 钩藤碱 | CAS号17391-18-3 柯诺辛B合成工艺路线路线简述
📜Tert-Butyl 2-Oxohex-5-Enoate置于bis(η3-Allyl-μ-Chloropalladium(II)),Caesium Carbonate,臭氧,三乙胺,N,N-二异丙基乙胺,1,2-双(二苯基膦)乙烷体系中,用 四氢呋喃,二氯甲烷,乙腈 作为反应溶剂,化学反应 16.41H,反应生成 去氢钩藤碱
参考文献:螺环羟吲哚生物碱棒碱,棒棒碱 B,棒棒碱和钩藤碱的全合成
标题:螺环羟吲哚生物碱棒碱,棒棒碱 B,棒棒碱和钩藤碱的全合成
摘要:报道了四种螺环羟吲哚生物碱的外消旋全合成.一般的起始材料是 N-2-丁烯基化的 2-羟色胺,它与官能化的醛进行碱介导的曼尼希螺环化反应以反应生成 C 环.第二个关键步骤是 Pd 催化的 α-酮酯烯醇化物(在原始醛中)环化到烯丙基碳酸酯(在 N 取代基中)以形成 D 环.关键步骤的立体选择性适中,但异构体易于纯化,可以方便地制备天然产物,其中三个是首次.
DOI:10.1002/ejoc.201201505
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2902700000-异丙基苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2025092433-A1
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids
发明人：CASARETTO JOSE; AKTAR TARIQ A; ROTHSTEIN STEVEN; SOUBEYRAND ERIC
权利人:MITRADYNE CORP
摘要:Described herein are polypeptides encoding enzymes for the synthesis of monoterpene indole alkaloids. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1-68, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1-68, or a fragment of the polypeptide, or the variant thereof.
专利号:EP-4538367-A2
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids
专利号:CN-120004790-A
优先权日:2023-11-15
标 题 :Synthesis method of spiro oxindole, ke Nayin and yohimbine alkaloid and derivatives thereof
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Chen L, Ma J, Wang X, Zhang M. Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC-MS/MS and Its Application in Pharmacokinetics and Bioavailability. Biomed Res Int. 2020 Aug 17;2020:1030269. doi: 10.1155/2020/1030269.
2: Flores-Bocanegra L, Raja HA, Graf TN, Augustinović M, Wallace ED, Hematian S, Kellogg JJ, Todd DA, Cech NB, Oberlies NH. The Chemistry of Kratom [Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids. J Nat Prod. 2020 Jul 24;83(7):2165-2177. doi: 10.1021/acs.jnatprod.0c00257. Epub 2020 Jun 29. 18(20):2742-2756. doi: 10.1080/15384101.2019.1656952. Epub 2019 Aug 29.
4: Li T, Xu K, He J, Jahan N, Song J, Wang S. Effects of isocorynoxeine, from Uncaria, on lower urinary tract dysfunction caused by benign prostatic hyperplasia via antagonism of α1A-adrenoceptors. Toxicol Appl Pharmacol. 2019 Aug 1;376:95-106. doi: 10.1016/j.taap.2019.05.018. Epub 2019 May 27.
合成参考文献
参考文献:10.1016/j.phymed.2018.04.034
摘要:Nakamura Y, Ishida Y, Kondo M, Shimada S. Yokukansan contains compounds that antagonize the 5-HT3 receptor. Phytomedicine. 2018 Apr 01;43():120–5. doi: 10.1016/j.phymed.2018.04.034.
参考文献:10.1111/j.2042-7158.1985.tb03023.x
摘要:Kanatani H, Kohda H, Yamasaki K, Hotta I, Nakata Y, Segawa T, Yamanaka E, Aimi N, Sakai S. The active principles of the branchlet and hook of Uncaria sinensis Oliv. examined with a 5-hydroxytryptamine receptor binding assay. J Pharm Pharmacol. 1985 Jun;37(6):401–4. doi: 10.1111/j.2042-7158.1985.tb03023.x.
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