CAS: 6188-43-8; Imidazo[1,2-A]Pyridine-3-Carbaldehyde

该化合物是一种多用途的七环甲醚,广泛用作有机合成和制药研究的关键中间体.其结合的imidazole-pyridine结构具有独特的反应性,使得它对于构建复杂的分子,特别是生物活性化合物和药物候选体的开发具有价值.甲醛功能组通过凝聚,减少或核生殖反应进一步衍生.该化合物在医药化学中特别有利,因为它在合成非丁胺[1,2,a]基于的鱼肉架中的作用,展示了广泛的药理活动.其稳定性和有丰富特性的再活性简介使它成为学术界和工业界研究人员的可靠建筑块.

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6200-60-8 123531-52-2 30489-43-1

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合成工艺路线路线简述

    📜3-[(二甲胺基)甲基]咪唑(1,2-Alpha)吡啶置于乌洛托品体系中,用 水,丙酸 作为反应溶剂,化学反应生成 咪唑并[1,2-A]吡啶-3-甲醛
    参考文献:Phosphonocarboxylate Compounds Pharmaceutical Compositions,And Methods
    标题:Phosphonocarboxylate Compounds Pharmaceutical Compositions,And Methods
    摘要:这项发明涉及包含药用可接受载体和磷酸羧酸盐或其药用可接受盐的组合物,其结构符合以下公式(i):##str1##

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    专利信息


    专利号:US-2009264648-A1
    优先权日:2008-01-14
    标题:Synthesis of pyrazoles
    发明人:CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO
    权利人:WYETH CORP; SIENA BIOTECH SPA
    摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

    专利号:US-11040939-B1
    优先权日:2020-06-23
    标 题 :N-transfer reagent and method for preparing the same and its application
    发明人:CHOU HO-HSUAN; LU GUAN-HAN; HSUEH HSIAO-CHIN; HUANG TZU-CHIA
    权利人:UNIV NAT CHENG KUNG
    摘要:Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): n n n n n n n n n n The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

    专利号:WO-2009091832-A1
    优先权日:2008-01-14
    标题 :Synthesis of pyrazoles

    专利号:CN-103435609-B
    优先权日:2013-09-09
    标 题 :Copper-catalyzed synthesis of imidazo[1,2-a]pyridine-3-carbaldehyde compounds

    专利号:CN-103435609-A
    优先权日:2013-09-09
    标 题 :Copper-catalyzed synthesis of imidazo[1, 2-a]pyridine-3-carbaldehyde compounds

    专利号:US-8178559-B2
    优先权日:2004-12-30
    标 题:Organic compounds
    发明人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
    权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
    摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

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    合成参考文献


    摘要:Spivey, A. C.; Tseng, C.-C., Science of Synthesis Knowledge Updates, (2010) 1, 35.
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