CAS: 610-14-0; 2-Nitrobenzoyl Chloride

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CAS号552-16-9 2-硝基苯甲酸 | CAS号98-88-4 苯甲酰氯 | CAS号104907-89-3 ethyl 5-(4-oxoq... | CAS号106015-61-6 2-(4-ethylpiper... | CAS号104907-82-6 ethyl 5-(2-ethy... | CAS号104035-16-7 (5-amino-1,2,4-... | CAS号107616-19-3 prop-2-enyl 2-n... | CAS号104907-90-6 ethyl 5-(2-meth... | CAS号10494-82-3 2-氨基-N-丁基苯甲酰胺( | CAS号104907-80-4 ethyl 1-methyl-... | CAS号104907-91-7 ethyl 5-(2-ethy... | CAS号52829-70-6 5-甲基-2-(2-硝基苯基)...

邻硝基苯甲酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 17.0H,反应生成 2-硝基苯甲酰氯
参考文献:苯并咪唑活化的硝基的分子内芳香亲核取代.
标题:苯并咪唑活化的硝基的分子内芳香亲核取代.
摘要:各种2-(2-硝基苯基)-1H-苯并咪唑在温和的条件下(dmf,Rt)经历高产率的亚硝酸盐分子内s(n)ar与n-侧链醇盐的结合.当此操作简单的过程在过量的nah存在下于高温下进行时,最初形成的s(n)ar产物会通过碱转化为相应的n-乙烯基取代的2-(2-羟苯基)-1H-苯并咪唑-催化的异构化.[反应:看文字]
DOI:10.1021/ol035761W

专利信息

专利号:US-8722886-B1
优先权日:2012-11-13
标题:Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
发明人：CHEN XINGHAI; HAUSHEER FREDERICK H; MALAKHOV ANDREY; KOCHAT HARRY
权利人:CHEN XINGHAI; HAUSHEER FREDERICK H; MALAKHOV ANDREY; KOCHAT HARRY; BIONUMERIK PHARMACEUTICALS INC
摘要:The present invention discloses and claims five (5) novel, highly efficient synthetic routes for the total synthesis of enantiomerically-pure (i.e., 99%) 7-(2′-trimethylsilyl)ethyl camptothecin (BNP1350; Karenitecin; Cositecan). These aforementioned synthetic schemes are the first to disclose the total syntheses of 7-(2′-trimethylsilyl)ethyl camptothecin using a highly novel direct, non-linear and convergent synthetic strategy which involves annealing the key C7-(trimethylsilyl)ethyl side chain-bearing A ring key synthons to an enantiomerically-pure tricyclic pyridone; rather than through the conventional methodology which incorporates the C7-(trimethylsilyl)ethyl side chain as the final synthetic step on a totally synthesized camptothecin parent compound. The current novel synthetic approaches reported herein since utilize desirably functionalized A-ring with preinstalled trimethyl silyl ethyl side chain, the aforementioned synthetic methodologies have a wider scope of making wide range of pharmaceutically relevant A-ring substituted BNP1350 analogs by substituting desirably functionalized nitro or protected amino phenyl carboxy A-ring as the starting material.

专利号:US-7557099-B2
优先权日:2004-03-01
标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
发明人：HOWARD PHILIP WILSON; KANG GYOUNG-DONG
权利人:SPIROGEN LTD
摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.

专利号:US-10336703-B2
优先权日:2015-05-12
标题 :Process for the synthesis of ivacaftor and related compounds
发明人：REDDY DUMBALA SRINIVASA; NATARAJAN VASUDEVAN; JACHAK GORAKHNATH RAJARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Ar 1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

专利号:US-5077408-A
优先权日:1989-09-20
标 题 :Process for the synthesis of oxazolopyridine compounds
发明人：GUILLAUMET GERALD; FLOUZAT CHRISTINE
权利人:SCIENCE ORGANISATION
摘要:Process for the synthesis of compounds of formula (I): ##STR1## their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; n R 1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; n 0≦m≦2; n R 2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group ##STR2## such that: R 3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, n 0≦n≦5 n employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.

专利号:US-2004092003-A1
优先权日:1997-03-19
标题:Multifunctional ceramic particles as solid supports for solid phase and combinatorial solid phase synthesis
发明人：BOSCHETTI EGISTO; KOCIS PETR
权利人:INVITROGEN CORP
摘要:Inert, thermally and mechanically stable porous ceramic solid phase supports for use in solid phase synthesis of molecules wherein the porous ceramic solid supports can be used under a wide variety of reaction conditions and in synthesis methods, including but not limited to organic, regular, multiple parallel, or combinatorial organic synthesis on a solid phase. Methods of using the porous ceramic solid supports for solid phase synthesis of molecules, for solid phase synthesis of polypeptides or peptidomimetics, for generating combinatorial libraries of linkers, and for combinatorial synthesis of compounds, including small molecules and aromatic and heteroaromatic compounds.

专利号:US-11981648-B2
优先权日:2019-06-13
标题:Method for the synthesis of 3-R-1,4,2-dioxazol-5-ones
发明人：HALL DAVID S; DAHN JEFFERY RAYMOND; HYNES TOREN
权利人:TESLA INC; PANASONIC HOLDINGS CORP
摘要:Provided are methods of preparing 3-R-1,4,2-dioxazol-5-one compounds using convenient and efficient methods. Also provided are 3-R-1,4,2-dioxazol-5-one compounds produced using the methods described.