CAS: 580-18-7; 3-Hydroxyquinoline

相似化合物

148-24-3 315228-46-7 6931-17-5

上下游产品

3-aminoquinoline 3-hydroxyquinoline-4-carboxylic acid quinoline quinolin-3-yl benzoate orthoformic acid-[3]quinolyl ester-diphenyl ester quinolin-3-yl benzoate toluene-4-sulfonic acid quinolin-3-yl ester 1,2,3,4-tetrahydroquinolin-3-ol

📜喹啉置于tris-(Dibenzylideneacetone)Dipalladium(0),水,Potassium Hydroxide体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 16.0H,以95%的收率获得产物3-羟基喹啉
参考文献:Me3(Ome)Tbuxphos: A Surrogate Ligand For Me4Tbuxphos In Palladium-Catalyzed C-n And C-o Bond-Forming Reactions
标题:Me3(Ome)Tbuxphos: A Surrogate Ligand For Me4Tbuxphos In Palladium-Catalyzed C-n And C-o Bond-Forming Reactions
摘要:A New Biarylphosphine Ligand,Me-3(Ome)Tbuxphos (L3),Was Designed As A Surrogate For Me(4)Tbuxphos (L1). The Me-3(Ome)Tbuxphos Could Be Prepared In A Chromatography-Free Manner From Inexpensive And Readily Available 2,3,6-Trimethylphenol. Comparative Studies Demonstrated That A Catalyst Based On Me-3(Ome)Tbuxphos Displayed The Same Reactivity As A Catalyst Based On Me(4)Tbuxphos For Pd-Catalyzed C-N And C-O Bond-Forming Processes.
DOI:10.1021/jo202537E

专利信息

专利号:US-5442065-A
优先权日:1993-09-09
标 题:Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
发明人：MAGNUS PHILIP D; ILIADIS THEODORE; EISENBEIS SHANE A; FAIRHURST ROBIN A
权利人:UNIV TEXAS
摘要:A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of the antitumor antibiotic dynemicin. The synthesis allows efficient production of the enediyne as a stable, compound in good yield from the adamantyl N-protected azabicyclo[7.3.1]tridecadiyne. The adamantyl protecting group is employed in the starting material, N-adamantyl dihydroquinoline or N-adamantyl 6-methoxy quinoline. Also disclosed are process for the synthesis of 3-hydroxy-6-methoxyquinoline and several N-substituted derivatives of azobicyclo[7.3.1]tridecaenediyne. Solid tumor and leukemia assays were performed on the analogs of dynemicin. The results suggest a method that these compounds will useful in treating certain types of leukemias and solid tumors. The disclosed synthesis provides a route to new dynemicin intermediates and analogs which will allow development of second and third generation dynemicins.

专利号:US-2006167025-A1
优先权日:2004-12-22
标 题:Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
发明人：BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
权利人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
摘要:The invention relates to tricyclic amino alcohols of general formula (I) n nmethod for synthesis of same and use of same as anti-inflammatory agents.

专利号:US-2004072738-A1
优先权日:2000-12-21
标 题 :Analogues of thiocoraline and be-22179
发明人：BOGER DALE L
摘要:A process for the total synthesis of thiocoraline and BE-22179 establishes the relative and absolute stereochemistry of these compounds and enables the construction and characterization of a series of related analogues. The mechanism for the bioactivity of thiocoraline, BE-22179 and their related analogues is charaterized. Thiocoraline, BE-22179, and their related analogues are disclosed to bind to DNA by high-affinity bisintercalation and are disclosed to exhibit exceptional cytotoxic activity.

专利号:US-11390645-B2
优先权日:2016-08-08
标题:Process for the preparation of 3β-hydroxy-17-(1H-benzimidazol-1-YL) androsta-5,16-diene
发明人：BARBIERI FRANCESCO; LENNA ROBERTO
权利人:IND CHIMICA SRL
摘要:A process for the synthesis of β-hydroxy 3-17-(1H-benzimidazol-1-yl)androsta-5,16-diene is described, a compound also known as Galeterone and used in the treatment of prostate cancer, having the formula (6).

专利号:EP-0839807-A1
优先权日:1996-10-30
标题:Synthesis of benzo(f)quinolinones

专利号:RU-2749134-C1
优先权日:2016-08-08
标 题:METHOD FOR SYNTHESIS OF 3β-HYDROXY-17-(1H-BENZIMIDAZOL-1-YL)ANDROSTA-5,16-DIENE