CAS: 56824-20-5; Amiprilose

该化合物是一种化学化合物,主要因其在药理学领域的应用而得到承认,被归类为抗血压剂,这意味着用于管理高血压;该化合物是被称为imidazoline衍生物的物质类衍生物,众所周知,这些物质具有与身体中特定受体互动的能力,尤其是与调节血管音和血压有关的受体进行互动的能力;盐碱盐通常被作为白色的脱白晶粉呈现,在正常储存条件下,这种物质在水中溶解,在表面稳定;其作用机制包括调节同情的...

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CAS号53914-14-0 1,2:5,6-DI-O-IS... | CAS号5407-04-5 3-二甲氨基氯丙烷盐酸盐 | CAS号582-52-5 双丙酮葡萄糖

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    专利号:US-5532147-A
    优先权日:1991-08-06
    标题:Enzymatic method for synthesis of carbohydrates
    发明人:NILSSON KURT
    摘要:A synthetic method in which is included at least one process, which is characterized by that a glycosidase (EC 3.2) is used to catalyse a reaction between a partially protected galactose derivative, or a partially protected glucose derivative, and a glycosyl doner, which is an oligosaccharide or a monosaccharide glycoside, is described. The process is suitable for synthesis of carbohydrate derivatives or for synthesis of partially protected carbohydrate intermediates which are suitable for further synthesis e.g. of blood group determinants A and B, or other carbohydrates.

    专利号:US-5432163-A
    优先权日:1992-11-13
    标题:Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
    发明人:AKHTAR M NAYEEM; THOMSON DAVID S; ARORA SUDERSHAK K
    权利人:GREENWICH PHARMA
    摘要:Compounds of this invention are derivatives of pentose monosaccharides which exhibit anti-proliferative and anti-inflammatory activity as well as intermediates for the synthesis of these compounds. Methods of preparation, pharmaceutical compositions containing the compounds and methods of treating inflammatory and/or autoimmune disorders employing the compounds are disclosed.

    专利号:US-5344924-A
    优先权日:1991-02-20
    标 题 :Solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof
    发明人:ARORA SUDERSHAN K
    权利人:GREENWICH PHARMA
    摘要:A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of: n 1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base; n 2) heating the mixture to a temperature sufficient to allow the mixture to react; n 3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced; n 4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture; n 5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally, n 6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups.

    专利号:US-2002173632-A1
    优先权日:2001-01-22
    标 题 :Synthesis of furanose and aminofuranose compounds

    专利号:WO-9214745-A1
    优先权日:1991-02-20
    标题 :New and improved solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof

    专利号:WO-9303168-A1
    优先权日:1991-08-06
    标 题:Enzymatic method for synthesis of carbohydrates

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    主要参考文献


    1: Chang DM. Immunoregulatory effects of a synthetic monosaccharide. Immunopharmacol Immunotoxicol. 1995 Aug;17(3):437-50. Review. Review.

    合成参考文献


    摘要:Weinblatt ME, Fraser PA, Anderson R, Coblyn JS, Trentham DE. Diminution of the T8 subset by amiprilose hydrochloride in refractory RA. J Rheumatol. 1987 Aug;14(4):859–60.
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