专利号:US-5532147-A 优先权日:1991-08-06 标题:Enzymatic method for synthesis of carbohydrates 发明人:NILSSON KURT 摘要:A synthetic method in which is included at least one process, which is characterized by that a glycosidase (EC 3.2) is used to catalyse a reaction between a partially protected galactose derivative, or a partially protected glucose derivative, and a glycosyl doner, which is an oligosaccharide or a monosaccharide glycoside, is described. The process is suitable for synthesis of carbohydrate derivatives or for synthesis of partially protected carbohydrate intermediates which are suitable for further synthesis e.g. of blood group determinants A and B, or other carbohydrates.
专利号:US-5432163-A 优先权日:1992-11-13 标题:Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides 发明人:AKHTAR M NAYEEM; THOMSON DAVID S; ARORA SUDERSHAK K 权利人:GREENWICH PHARMA 摘要:Compounds of this invention are derivatives of pentose monosaccharides which exhibit anti-proliferative and anti-inflammatory activity as well as intermediates for the synthesis of these compounds. Methods of preparation, pharmaceutical compositions containing the compounds and methods of treating inflammatory and/or autoimmune disorders employing the compounds are disclosed.
专利号:US-5344924-A 优先权日:1991-02-20 标 题 :Solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof 发明人:ARORA SUDERSHAN K 权利人:GREENWICH PHARMA 摘要:A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of: n 1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base; n 2) heating the mixture to a temperature sufficient to allow the mixture to react; n 3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced; n 4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture; n 5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally, n 6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups.
专利号:US-2002173632-A1 优先权日:2001-01-22 标 题 :Synthesis of furanose and aminofuranose compounds
专利号:WO-9214745-A1 优先权日:1991-02-20 标题 :New and improved solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof
专利号:WO-9303168-A1 优先权日:1991-08-06 标 题:Enzymatic method for synthesis of carbohydrates
1: Chang DM. Immunoregulatory effects of a synthetic monosaccharide. Immunopharmacol Immunotoxicol. 1995 Aug;17(3):437-50. Review. Review.
合成参考文献
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