专利号:US-4918173-A 优先权日:1985-07-02 标 题 :2',6'-Dideoxy derivatives of anthracycline glycosides 发明人:MONNERET CLAUDE; FLORENT JEAN-CLAUDE; GENOT AGNES 权利人:HOECHST SA LAB 摘要:The present invention relates to new tetralins and their use for the preparation of anthracyclinones and anthracyclins. These tetralins contain at least one chiral carbon atom and correspond to the formula (V) below: (V) in which: R1 and R2 denote a hydrogen atom, or a halogen atom or the group OCH3, provided that one of the two substituents (R1 or R2) must denote OCH3, and R3 denotes a hydrogen atom or the OR' group, R' being hydrogen or a hydroxyl-protecting group. Application: synthesis of glycosides of great therapeutic value.
专利号:CN-112206784-B 优先权日:2020-08-31 标题:Application of Catalysts Supported by Metal Mesh Particles in Catalytic Synthesis of Pterostilbene
专利号:US-7691843-B2 优先权日:2002-07-11 标 题 :N-hydroxyamide derivatives possessing antibacterial activity 发明人:RAJU BORE G; O'DOWD HARDWIN; GAO HONGWU; PATEL DINESH V; TRIAS JAOQUIM 权利人:PFIZER 摘要:Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
专利号:US-5462954-A 优先权日:1991-11-25 标题:Substituted phenyl phenol leukotriene antagonists 发明人:BAKER S RICHARD; DILLARD ROBERT D; FLOREANCIG PAUL E; SAWYER J SCOTT; SOFIA MICHAEL J 权利人:LILLY CO ELI 摘要:Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and synthesis are disclosed. Also, pharmaceutical formulations are disclosed for use in applications treating diseases or conditions characterized by excessive release of leukotriene B4, one of the metabolites of arachidonic acid. The primary LTB4 antagonistic structures are represented as:
参考标题:Modular Synthesis Of Drimane Meroterpenoids Leveraging Decarboxylative Borylation And Suzuki Coupling 作者:Xia Wang,Shasha Zhang,Pengcheng Cui,Shengkun Li |发布日期:2020.11.6 摘要:Conspicuous Challenge. A New Paradigm Merging Decarboxylative Borylation And Suzuki Coupling Was Developed As A Powerful Platform. Key Features Include The Mild Conditions, Good Chemoselectivity, Operational Facility, Scalability, And Easy Availability Of The Coupling Partners. This Practical Strategy Enables The Expedient Formal Synthesis Of A Large Number Of Natural Products And Rapid Generation Of Analogues
合成参考文献
参考文献:10.1107/s1600536811008440 摘要:Cheng W, Feng ZQ, Tang JM. Bis(3,5-dimeth-oxy-phen-yl)phosphinic acid. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o896.