专利号:US-7173059-B2 优先权日:2003-05-08 标题:Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same 发明人:ALBIZATI KIM FRANCIS; BABU SRINIVASAN 权利人:AGOURON PHARMA 摘要:Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed.
专利号:US-6472534-B2 优先权日:1999-10-21 标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors 发明人:BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K 权利人:AGOURON PHARMA 摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
专利号:US-2006229475-A1 优先权日:2005-04-11 标题:Synthesis of hydroxylated hydrocarbons 发明人:WEISS MICHAEL J; SUN SHOULI 权利人:WEISS MICHAEL J; SUN SHOULI 摘要:Ethylene glycol, other diols, triols, and polyols are made in an efficient manner by reacting dibromides with water in the presence of a metal oxide. An integrated process of dibromide formation, alcohol synthesis, metal oxide regeneration, and bromine recycling is also provided.
专利号:US-8034966-B1 优先权日:2008-02-20 标 题:Phenoxyisobutyric acid compounds and methods for synthesis 发明人:LALEZARI IRAJ; FABRICANT JILL 权利人:CELL VIABLE CORP 摘要:The present invention provides a process for the synthesis of substituted arylureidophenoxymethylpropionic acid and related compounds including bifunctional and tetrafunctional derivatives. The compounds are useful for inhibiting the formation of AGEs (Aminaglycation end products).
专利号:US-8975427-B2 优先权日:2010-04-28 标题 :Synthesis of alkyl cyclopentadiene compounds 发明人:HARLAN C JEFF; CAO XIANYI; RIX FRANCIS C 权利人:HARLAN C JEFF; CAO XIANYI; RIX FRANCIS C; UNIVATION TECH LLC 摘要:A method of synthesizing an alkyl cyclopentadiene compound is disclosed. The method includes contacting at least one cyclopentadienyl anion source and at least one alkyl group source to form at least one alkyl cyclopentadiene compound. The method further includes extracting the alkyl cyclopentadiene compound with a hydrocarbon solvent. The alkyl cyclopentadiene compound may be converted to a metallocene catalyst compound.
专利号:US-3829522-A 优先权日:1971-10-21 标题:Synthesis of alkynes by dehydrohalogenation 发明人:SCHNEIDER C 权利人:SHERWIN WILLIAMS CO 摘要:MIXTURE AS A CONDENSED LIQUID. THE ALKYNE PRODUCTS ARE OBTAINED IN HIGH YEILD. A PROCESS FOR PREPARING ALKYNES OF HIGH PURITY BY DEHYDROGENATION. HALOGENATED PRECURSORS CONSISTING OF DIHALOALKANES AND MONOHALOALKENES ARE REACTED WITH PARTIAL ALCOHOLATE OF AN ALKALI METAL AND AN ALIPHATIC POLYOL. THE REACTION MIXTURE REMAINS FLUID DURING THE PROCESS. ALKYNES AND VOLATILE BY-PRODUCTS ARE EVAPORATED FROM THE REACTION MIXTURE AND PARTIALLY CONDENSED IN A SEPARATION TO RECOVER THE HIGH-PURITY ALKYNE PRODUCT. THE VOLATILE BY-PRODUCTS ARE RETURNED TO THE REACTION
参考标题:Convenient Synthesis Of Cyclic Trithiocarbonates From 1,2- Or 1,3-Dihaloalkanes And Sodium Trithiocarbonate In The Presence Of Phase-Transfer Catalyst 作者:Akira Sugawara,Tsukasa Sato,Ryu Sato |发布日期:1989.1 摘要:Cyclic Trithiocarbonates, Such As 1,3-Dithiolane-2-Thiones And 1,3-Dithiane-2-Thiones, Were Conveniently Synthesized By Treating 1,2- Or 1,3-Dihaloalkanes With Sodium Trithiocarbonate In The Presence Of A Phase-Transfer Catalyst.
合成参考文献
摘要:Jończyk, A.; Kowalkowska, A., Science of Synthesis, (2006) 8, 1014. 摘要:Troll, T., Science of Synthesis, (2007) 35, 445.