CAS: 5151-34-8; 2,4-Dimethoxy-5-Methylpyrimidine

上下游产品

CAS号56686-16-9 5-溴-2,4-二甲氧基嘧啶 | CAS号74-88-4 碘甲烷 | CAS号3551-55-1 2,4-二甲氧基嘧啶 | CAS号25902-89-0 2(1H)-Pyrimidin... | CAS号77-78-1 硫酸二甲酯 | CAS号1780-31-0 2,4-二氯-5-甲基嘧啶 | CAS号124-41-4 甲醇钠 | CAS号65-71-4 胸腺嘧啶 | CAS号7647-01-0 盐酸 | CAS号65-71-4 胸腺嘧啶 | CAS号52606-02-7 2,4-二甲氧基5-嘧啶甲醛 | CAS号68724-11-8 1-(2-羟基乙氧基)甲基-5... | CAS号2140-61-6 5-甲基胞苷

📜胸腺嘧啶 以86%的收率获得产物2,4-二甲氧基-5-甲基嘧啶
参考文献:Synthetic Nucleosides And Nucleotides. Xxviii. Synthesis Of 5-Alkylcytidines From 5-Alkylbarbituric Acids.
标题:Synthetic Nucleosides And Nucleotides. Xxviii. Synthesis Of 5-Alkylcytidines From 5-Alkylbarbituric Acids.
摘要:5-烷基巴比妥酸(1B-F)在n,N-二乙基苯胺盐酸盐存在下,使用磷酰氯在回流的正丁基乙酸酯中转化为5-烷基-2,4,6-三氯嘧啶(2B-F).将2与甲氧基钠在干燥乙腈中处理,随后与乙基硫醇钾反应并在raney Ni存在下脱硫,得到本研究的关键中间体5-烷基-2,4-二甲氧基嘧啶(5B-F).在乙腈中锡氯存在下,将5与1-O-乙酰基-2,3,5-三-O-苯甲酰基-β-D-呋喃核糖反应,定量得到5-烷基-1-(2,3,5-三-O-苯甲酰基)-β-D-呋喃核糖基-1,2-二氢-4-甲氧基嘧啶-2-酮(6A-F).用甲醇氨处理6得到标题5-烷基胞嘧啶核苷(7A-F).化合物6也很容易通过与盐酸处理转化为相应的尿嘧啶核苷.还研究了7对培养的小鼠白血病l5178Y细胞的生长抑制作用,对培养的chse-214细胞中的传染性造血坏死病毒(ihnv)的抗病毒活性以及作为人胞嘧啶脱氨酶底物的性质.
DOI:10.1248/cpb.36.2673

专利信息

专利号:WO-2021062168-A1
优先权日:2019-09-25
标 题 :Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment
发明人：EDINGER AIMEE; HANESSIAN STEPHEN
权利人:UNIV CALIFORNIA; UNIV MONTREAL
摘要:Small molecules compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

专利号:US-11020399-B2
优先权日:2011-05-04
标 题:Intermediates useful in the synthesis of compounds as modulators of protein kinases