CAS: 454712-26-6; Tert-Butyl 3-(Methylamino)Pyrrolidine-1-Carboxylate

相似化合物

147081-59-2 199336-83-9 64021-83-6

上下游产品

CAS号101385-93-7 1-叔丁氧碳基-3-吡咯烷酮 | CAS号74-89-5 氨基甲烷 | CAS号862906-27-2 tert-butyl 3-(b...

📜Tert-Butyl 3-[methyl-(2-Nitrophenyl)Sulfonylamino]Pyrrolidine-1-Carboxylate置于potassium Carbonate体系中,用 乙腈 作为反应溶剂,化学反应 12.0H,反应生成 1-Boc-3-甲氨基吡咯烷
参考文献:发现了一种新型的双环化合物ds54360155,它是一种口服有效的止痛药,没有mu阿片类受体激动剂活性.
标题:发现了一种新型的双环化合物ds54360155,它是一种口服有效的止痛药,没有mu阿片类受体激动剂活性.
摘要:我们合成了天然生物碱,可可定的衍生物,并在口服后在ddy小鼠中的乙酸诱导的扭体试验和福尔马林试验中评估了这些衍生物.结果,我们确定了(5 S)-6-甲基-1,3,4,5,6,8-六氢-7H-2,5-甲基[1,5]重氮基[7,8-B]吲哚-7-硫酸盐15A(ds54360155)具有独特的原始双环骨架,比可可啶具有更强的镇痛作用.此外,15A没有表现出μ阿片受体激动剂活性.
DOI:10.1016/j.Bmcl.2019.126748

专利信息

专利号:WO-0007607-A1
优先权日:1998-08-04
标 题:Nutrient and therapeutic compositions for the treatment of cancer
权利人:KOSBAB JOHN V
摘要:This invention relates to nutrient and therapeutic compositions for the treatment of cancer symptoms and conditions. Compositions of this invention contain a mixture of antioxidants, components that promote collagen maintenance and synthesis, components that regulate blood lipids, glucose and/or insulin, and lower homocysteine levels. Compositions also provide supplementation for nutrient (vitamin, mineral and cofactor) deficiencies to restore and maintain normal biochemical function. Cancer formulations, particularly those adapted for treatment of female cancers, can be combined with components that provide benefit in osteoporosis.

专利号:US-8030501-B2
优先权日:2006-07-28
标题 :Process for producing optically active 3-amino nitrogen-containing compounds
发明人：OHNUKI MASATOSHI; IZUMIDA MASASHI; NISHIYAMA AKIRA; MATSUMOTO SHINGO
权利人:KANEKA CORP
摘要:Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.

专利号:CN-116103257-A
优先权日:2023-03-11
标 题 :Reductive amination enzyme mutant and application thereof in synthesis of alkylated pyrrolidine chiral amine

专利号:US-9676772-B2
优先权日:2013-07-25
标题 :Pyrroloquinoline derivatives as 5-HT6 antagonists, preparation method and use thereof
发明人：ZAJDEL PAWEL; GRYCHOWSKA KATARZYNA; PAWLOWSKI MACIEJ; PARTYKA ANNA; WESOLOWSKA ANNA; BOJARSKI ANDRZEJ J; POPIK PIOTR; KOS TOMASZ; SATALA GRZEGORZ; LAMATY FREDERIC; COLACINO EVELINA; MARTINEZ JEAN; SUBRA GILLES; BANTREIL XAVIER
权利人:CENTRE NAT RECH SCIENT; UNIV MONTPELLIER; UNIV JAGIELLONSKI; INST FARMAKOLOGII POLSKIEJ AKADEMII NAUK; Uniwersyter Jagiellonski
摘要:This invention concerns pyrroloquinoline derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in schizophrenia, anxiety, depression, maniac depression, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, panic attacks, attention deficit hyperactivity disorder, attention deficit disorder, Parkinson's disease, Huntington's disease, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, obesity and type-2 diabetes, functional bowel disorder, Irritable Bowel Syndrome. The compounds have the general formula (XIV), wherein the symbols have the meanings given in the description.

专利号:CN-110684003-A
优先权日:2019-09-30
标题:Simple and efficient total synthesis method of icaritin and derivatives thereof