CAS: 452-62-0; 3-Bromo-4-Fluorotoluene

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CAS号542-56-3 亚硝酸异丁酯 | CAS号583-68-6 2-溴-4-甲基苯胺 | CAS号352-32-9 对氟甲苯 | CAS号13194-71-3 2-溴-4-甲基苯胺盐酸盐 | CAS号106-49-0 对甲苯胺 | CAS号56-23-5 四氯化碳 | CAS号7726-95-6 溴素 | CAS号52723-82-7 4-溴-5-氟-2-甲基苯胺 | CAS号321-12-0 2-氟-5-甲基苯甲酸 | CAS号452-84-6 2-氟-5-甲基苯胺 | CAS号78239-71-1 3-溴-4-氟苄溴 | CAS号656-64-4 3-溴-4-氟苯胺 | CAS号672-75-3 3-溴-4-氟苯甲酰氯 | CAS号1007-16-5 3-溴-4-氟苯甲酸 | CAS号64977-30-6 2-氟-5-甲基苯甲醇 | CAS号861928-20-3 1-溴-2-氟-4-碘-5-甲基苯 | CAS号89981-02-2 3-Bromo-4-(Meth...

对氟甲苯置于四氯化碳,溴,铁粉体系中,化学反应生成 3-溴-4-氟甲苯
参考文献:Varma; Raman; Nilkantiah,Journal Of The Indian Chemical Society,1944,Vol. 21,P. 112,114
标题:Varma; Raman; Nilkantiah,Journal Of The Indian Chemical Society,1944,Vol. 21,P. 112,114

专利信息

专利号:US-6825185-B2
优先权日:2000-12-21
标题:Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：KHANAPURE SUBHASH P; GARVEY DAVID S; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GASTON RICKY D
权利人:NITROMED INC
摘要:The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or, optionally, at least one therapeutic agent, such as, steroids, nonsterodal antiinflammatory compounds (NSAID), 5-lipoxygenase (5-LO) inhibitors, leukotriene B 4 (LTB 4 ) receptor antagonists, leukotriene A 4 (LTA 4 ) hydrolase inhibitors, 5-HT agonists, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitors, H 2 antagonists, antineoplastic agents, antiplatelet agents, thrombin inhibitors, thromboxane inhibitors, decongestants, diuretics, sedating or non-sedating anti-histamines, inducible nitric oxide synthase inhibitors, opioids, analgesics, Helicobacter pylori inhibitors, proton pump inhibitors, isoprostane inhibitors, and mixtures thereof. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity or other toxicities; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:US-7205300-B2
优先权日:1997-12-31
标 题:Aryl fused azapolycyclic compounds
发明人：COE JOTHAM WADSWORTH; BROOKS PAIGE ROANNE PALMER
权利人:PFIZER
摘要:This invention is directed to compounds of the formula (I): n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.

专利号:US-4229368-A
优先权日:1978-05-04
标题 :Esters and thiolesters of unsaturated acids
发明人：ANDERSON RICHARD J; HENRICK CLIVE A
权利人:ZOECON CORP
摘要:Esters and thiolesters of α-substituted unsaturated acids, intermediates therefor, synthesis thereof, and the use of said esters and thiolesters and compositions thereof for the control of pests.

专利号:US-4225533-A
优先权日:1979-06-01
标题:Fluorobenzyl esters of cyclopropanecarboxylic acids
发明人：HENRICK CLIVE A
权利人:ZOECON CORP
摘要:Novel esters of ether and thioether substituted cyclopropanecarboxylic acids, synthesis thereof, and intermediates therefor, such esters being useful as pesticides.

专利号:US-4446075-A
优先权日:1980-02-22
标 题:Substituted bromofluorobenzene derivatives and process for its manufacture
发明人：EIGLMEIER KURT; KNIEPS REINHARD
权利人:RIEDEL DE HAEN AG
摘要:Substituted bromofluorobenzene, wherein the fluorine is in para-position and the bromine in meta-position to another substituent, is prepared by direct bromination of the corresponding fluorobenzene derivative. Bromination is advantageously carried out in the presence of a catalyst, preferably a metal or metal salt. The elementary bromine is used in an amount of 0.9 to 1.3 mols per mol of fluorobenzene derivative and the reaction temperature is between 20° and 200° C. The bromofluorobenzene derivatives are suitable for the synthesis of medicaments and plant protective agents.

专利号:US-7563900-B2
优先权日:2004-10-13
标 题:Process for the preparation N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methane sulfonamido-dibenzo[b,d]furan-1-carboxamide
发明人：GOPALAN BALASUBRAMANIAN; GHARAT LAXMIKANT A; CHANDRASEKHAR BATCHU; PILLAI BIJUKUMAR G
权利人:GLENMARK PHARMACEUTICALS SA
摘要:The present invention relates to a method of preparing N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof, such as its sodium salt, and novel intermediate compounds useful in the synthesis of the aforementioned compound.