CAS: 4289-97-8; N-Formyl-L-Valine

相似化合物

103478-58-6 1149-26-4 13734-41-3

上下游产品

formic acid D,L-valine N-[1-(Benzoimidazole-1-carbonyl)-2-methyl-propyl]-formamide formyl acetic anhydrideD-Val-OH L-valine N-formyl-DL-valine anilideN-formyl-DL-valine anilide N-(N-formyl-valyl)-phenylalanine ; optically inactive substanceN-(N-formyl-valyl)-phenylalanine ; optically inactive substance

📜L-缬氨酸,Formyloxyacetoxyphenylmethane置于碳酸氢钠体系中,用 水 作为反应溶剂,化学反应 16.0H,以78%的收率获得产物formyl-L-缬氨酸
参考文献:甲酰氧基乙酰氧基苯基甲烷作为胺,氨基酸和肽的n-甲酰化试剂
标题:甲酰氧基乙酰氧基苯基甲烷作为胺,氨基酸和肽的n-甲酰化试剂
摘要:Formyloxyacetoxyphenylmethane是一种稳定的,水耐受性,ñ对于可以无溶剂的条件下在室温下可用于制备一系列的伯和仲胺-Formylating试剂ñ-Formamides,ñ-Formylanilines,ñ甲酰基α氨基酸,N-甲酰基肽和异氰化物.
DOI:10.1021/acs.Orglett.7B02382

专利信息

专利号:WO-0037486-A1
优先权日:1998-12-22
标题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
权利人:HOLLAND SWEETENER CO; QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-α-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-α- and β-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:US-6617127-B2
优先权日:1998-12-22
标题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER J L M; SONKE THEODORUS; WAGNER ADOLF F V
权利人:HOLLAND SWEETENER CO
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-alpha-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-alpha- and beta-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:EP-1140982-B1
优先权日:1998-12-22
标 题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
权利人:HOLLAND SWEETENER CO
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl- alpha -L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl- alpha - and beta -L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:US-8124794-B2
优先权日:2002-04-17
标题:Method for the asymmetric synthesis of beta-lactone compounds
发明人：SMITH JEFFREY W; AXELROD FUMIKO; KRIDEL STEVEN J; ROMO DANIEL; PUROHIT VIKRAM; MA GIL
权利人:SMITH JEFFREY W; AXELROD FUMIKO; KRIDEL STEVEN J; ROMO DANIEL; PUROHIT VIKRAM; MA GIL; SANFORD BURNHAM MED RES INST
摘要:The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

专利号:US-2006258620-A1
优先权日:2002-04-17
标 题:Novel method for the asymmetric synthesis of beta-lactone compounds

专利号:CN-109810057-A
优先权日:2019-02-26
标 题 :A kind of method of palladium chtalyst asymmetry c h bond amine carbonylation synthesis of chiral isoquinolin