CAS: 402-24-4; 1-(Trifluoromethyl)-3-Vinylbenzene

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2-[3-(trifluoromethyl)phenyl]ethanol 1-(3-trifluoromethylphenyl)ethanol 2-(-m-Trifluormethylphenyl)ethylfluorid vinyllithium 1,1-Dichlor-2-m-trifluormethyl-phenyl-cyclopropan 1,1-bis(ethoxycarbonyl)-2-(m-trifluoromethylphenyl)cyclopropane 5,8]°Ctadeca-1(15),5(18),6,8(17),12(16),13-hexaene(2S,4S)-2-Methyl-4-[(E)-2-(3-trifluoromethyl-phenyl)-vinyl]-tricyclo[10.2.2.25,8]°Ctadeca-1(15),5(18),6,8(17),12(16),13-hexaene 5,8]°Ctadeca-1(15),5(18),6,8(17),12(16),13-hexaene(2R,4S)-2-Methyl-4-[(E)-2-(3-trifluoromethyl-phenyl)-vinyl]-tricyclo[10.2.2.25,8]°Ctadeca-1(15),5(18),6,8(17),12(16),13-hexaene

📜1-(3-三氟甲基苯基)乙醇 反应生成 间三氟甲基苯乙烯
参考文献:将游离三氯甲基自由基添加到取代苯乙烯中的相对反应性.尝试分离极性和共振效应
标题:将游离三氯甲基自由基添加到取代苯乙烯中的相对反应性.尝试分离极性和共振效应
摘要:已使用未取代的苯乙烯研究过氧化二苯甲酰催化将溴代三氯甲烷加成到九个核取代苯乙烯中的相对反应性.间位取代基对相对速率的影响与使用 σ 或 σ+ 常数的简单哈米特方程相关.然而,对位取代苯乙烯的相对速率不符合简单的哈米特关系,结果最好根据极性 (ρσ+) 和共振 (Ed) 项进行解释.检查的所有对位取代基都增加了反应性.log(K⁄kh)=ρσ++ed Ed 项显示出与 Alfrey-Price 自由基共聚 Qe 方案中相应对苯乙烯的 Logq 的惊人相关性.极性项源于烯烃和亲电三氯甲基自由基之间的电荷转移相互作用,可以用 ρσ+ 表示,这进一步得到取代苯乙烯的电荷转移能与 σ+ 具有非常好相关性的证据的支持.影响因素...
DOI:10.1246/bcsj.44.1945

专利信息

专利号:US-8541524-B2
优先权日:2006-07-04
标 题 :Free-radical polymerization process in aqueous dispersion for the preparation of a block copolymer at least one block of which is a block of a halogenated polymer
发明人：FRINGANT CHRISTOPHE; VANDERVEKEN YVES; LACROIX-DESMAZES PATRICK; TONNAR JEFF
权利人:FRINGANT CHRISTOPHE; VANDERVEKEN YVES; LACROIX-DESMAZES PATRICK; TONNAR JEFF; SOLVAY
摘要:Process of controlled free-radical polymerization in aqueous dispersion for the preparation of a block copolymer at least one block of which is a block of a halogenated polymer using molecular iodine and at least one oxidant whose solubility in water is at least 10 g/l for the synthesis of the first block of the block copolymer.

专利号:US-8470889-B2
优先权日:2008-11-26
标题:Hybrid-ionone and curcumin molecules as anticancer agents
发明人：Wu jian hui; BATIST GERALD; ZHOU JINMING; GENG GUOYAN; LIN RONGTUAN; LI YI
权利人:Wu jian hui; BATIST GERALD; ZHOU JINMING; GENG GUOYAN; LIN RONGTUAN; LI YI; TRT PHARMA INC
摘要:The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesized and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.

专利号:CN-115403494-A
优先权日:2022-06-09
标题 :A method for the synthesis of β-hydroxysulfone derivatives by oxygen-initiated difunctionalization of alkenes under mild conditions

专利号:CN-115403494-B
优先权日:2022-06-09
标题:A method for the synthesis of β-hydroxysulfone derivatives by oxygen-initiated difunctionalization of olefins under mild conditions

专利号:US-7671085-B2
优先权日:2002-11-15
标 题 :Non-steroidal farnesoid X receptor modulators and methods for the use thereof
发明人：DOWNES MICHAEL R; EVANS RONALD M
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. In accordance with the present invention, the identification of novel potent FXR activators is described. Two derivatives of invention compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds are useful as chemical tools to further define the physiological role of FXR as well as therapeutic leads for the treatment of diseases linked to cholesterol, bile acids and their metabolism and homeostasis.

专利号:US-8173628-B2
优先权日:2000-06-22
标 题:Steroidal antiestrogens and antiandrogens and uses thereof
发明人：HANSON ROBERT N; FRIEL CAROLYN; LEE CHOON YOUNG
权利人:HANSON ROBERT N; FRIEL CAROLYN; LEE CHOON YOUNG; UNIV NORTHEASTERN
摘要:The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorder. In an aspect of the invention, such treatments include therapeutic compositions comprising novel steroidal antiestrogen and antiandrogen compounds. In a preferred aspect, such a novel compound of the present invention has an address and a message component, which are made into a single composite entity for more aggressive intervention and effective treatment of hormone-responsive disorders, thereby prolonging the disease-free interval for the patient and reducing a number of side effects.