CAS: 3731-16-6; 3-Carbethoxy-2-Piperidone

相似化合物

41888-21-5 25219-43-6 1448544-64-6

上下游产品

CAS号17216-62-5 二乙基 2-(2-氰基乙基)丙二酸 | CAS号105-53-3 丙二酸二乙酯 | CAS号41888-21-5 2-氧代哌啶-3-羧酸 | CAS号17952-83-9 6-chloro-2,3,4,... | CAS号84-26-4 吴茱萸次碱 | CAS号3335-05-5 1,4,5,6-四氢吡啶-3-羧酸乙酯 | CAS号17952-82-8 1,2,3,4-四羟基去甲哈尔满-1-酮 | CAS号833436-57-0 ethyl 3-(2-indo... | CAS号94850-47-2 (3E)-3-[(4-Meth... | CAS号5376-46-5 5,8-dichloro-2,... | CAS号5956-86-5 3-(2-aminoethyl...

烯丙基丙二酸二乙酯置于magnesium(II) Perchlorate,2,2,6,6-四甲基哌啶氧化物,Oxone,三氯异氰尿酸,10 Wt% Pd(Oh)2 On Carbon,氢气体系中,用 四氢呋喃,Aq. Phosphate Buffer,乙醇,二氯甲烷,水,乙酸乙酯,异丙醇,丙酮 用作溶剂,60.0 °C,101.33 Kpa 条件下,反应 43.08H,反应生成2-氧-3-哌啶羧酸乙酯
参考文献:功能化的环丙烷作为多功能中间体,用于γ-内酯,γ-内酰胺和δ-内酰胺的多样性导向合成
标题:功能化的环丙烷作为多功能中间体,用于γ-内酯,γ-内酰胺和δ-内酰胺的多样性导向合成
摘要:本文描述了由γ,δ-环氧酯制备环丙烷甲醛-1,1-二酯的两步程序及其合成多功能性.环氧化物的开环/环丙烷化过程是在加热下存在mg(clo4)2的情况下发生的,从而以65%的收率获得环丙烷甲醇-1,1-二酯.轻度的tempo介导的该底物的氧化反应很容易以75%的收率生成相应的醛,该醛用于一锅法合成四个环亚丙基-γ-内酰胺和三个δ-内酰胺.另外,通过醛与phospho盐的维蒂希反应获得乙烯基环丙烷,并将其用作四氢呋喃的前体.
Doi:10.1055/a-1389-1203

专利信息

专利号:WO-9525088-A1
优先权日:1994-03-14
标 题:Pyridyl ethylation of lactam derivatives
发明人：CHUNG JOHN Y L; ZHAO DALIAN; MATHRE DAVID J
权利人:MERCK & CO INC; CHUNG JOHN Y L; ZHAO DALIAN; MATHRE DAVID J
摘要:The invention is a highly efficient synthesis for making compounds of formula (iv) wherein R is C1-4 alkyl or benzyl; and R1, when present, is C¿1-4? alkyl, OH, O-C1-4 alkyl, or S-C1-4 alkyl; which are useful intermediates for making compounds such as those represented in formula (I).

专利号:US-5686607-A
优先权日:1994-09-16
标题 :Pyridyl ethylation of lactam derivatives
发明人：CHUNG JOHN Y L; ZHAO DALIAN; MATHRE DAVID J
权利人:MERCK & CO INC
摘要:PCT No. PCT/US94/10518 Sec. 371 Date Aug. 29, 1996 Sec. 102(e) Date Aug. 29, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/25088 PCT Pub. Date Sep. 21, 1995The invention is a highly efficient synthesis for making compounds of formula (iv) wherein R is C1-4 alkyl or benzyl; and R1, when present, is C1-4 alkyl, OH, O-C1-4 alkyl, or S-C1-4 alkyl; which are useful intermediates for making compounds such as those represented in formula (I). (iv) (I)

专利号:US-5405852-A
优先权日:1992-06-04
标题 :Amide derivatives
发明人：VEALE CHRIS A; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel amide ##STR1## derivatives which are pyrido[3,4-b]indol-2-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.

专利号:US-2025101038-A1
优先权日:2021-12-24
标 题 :Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.