CAS: 33216-52-3; 3,4,5-Trichloropyridine

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CAS号110-86-1 吡啶 | CAS号17228-71-6 3,5-二氯-4-羟基吡啶 | CAS号7782-50-5 氯气 | CAS号7647-01-0 盐酸 | CAS号26482-55-3 4-Pyridinamine,... | CAS号5439-04-3 3,4,5-三氯吡啶-2-甲酸 | CAS号56-81-5 甘油 | CAS号153708-69-1 1-(3,5-二氯-4-吡啶基)肼 | CAS号33216-53-4 3,5-二氯-4-吡啶硫醇 | CAS号22889-78-7 4-氨基-3,5-二氯吡啶 | CAS号17228-71-6 3,5-二氯-4-羟基吡啶 | CAS号1247825-37-1 4-氰基-5-[(3,5-二氯... | CAS号955378-56-0 1-(3,5-二氯吡啶-4-基...

4-羟基吡啶置于n-Chloro-Succinamide,三氯氧磷体系中,用 水,乙腈 用作溶剂,化学反应 24.0H,反应生成3,4,5-三氯吡啶
参考文献: Methods For The Preparation Of 1,3-Benzodioxole Heterocyclic Compounds[fr] Procédés Pour La Préparation De Composés Hétérocycliques 1,3-Benzodioxole
标题: Methods For The Preparation Of 1,3-Benzodioxole Heterocyclic Compounds[fr] Procédés Pour La Préparation De Composés Hétérocycliques 1,3-Benzodioxole
摘要:本发明涉及一种用于制备式(I)的1,3-苯并二氧杂环己烯类化合物的新方法.这些化合物可用作pde4抑制剂.

专利信息

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.

专利号:CN-114105865-A
优先权日:2021-12-07
标题 :Synthesis process of 3,4, 5-trichloropyridine