苹果酸置于氢气体系中,用 水 用作溶剂,化学反应生成1,2,4-丁三醇 参考文献:Method For Producing Catalysts Containing Ruthenium And The Use Thereof For Hydrogenation 标题:Method For Producing Catalysts Containing Ruthenium And The Use Thereof For Hydrogenation 摘要:本发明涉及含有钌和至少一种原子序数在23至82范围内的其他金属的催化剂,制备方法包括:(A)将具有50至300平方米/克的特定比表面积的钌化合物悬浮液与至少一种金属化合物溶液混合,其中至少一种金属化合物含有不同于钌的金属,并且其原子序数在23至82范围内;(B)用还原剂处理悬浮液和溶液的混合物.
专利号:US-2024294462-A1 优先权日:2023-02-15 标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate 发明人:SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD 权利人:NANOVATION THERAPEUTICS INC 摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.
专利号:WO-2009135600-A1 优先权日:2008-05-07 标题:Catalysts for the synthesis of polyurethanes 发明人:LINDNER STEFAN; BAHNMUELLER STEFAN; SCHMIDT AXEL; WEIKARD JAN; BUCHMEISER MICHAEL; BANTU BHASKER; FRIEDERICHS WOLFGANG; KRAUSE JENS; REITER STEPHAN 权利人:BAYER MATERIALSCIENCE AG; LINDNER STEFAN; BAHNMUELLER STEFAN; SCHMIDT AXEL; WEIKARD JAN; BUCHMEISER MICHAEL; BANTU BHASKER; FRIEDERICHS WOLFGANG; KRAUSE JENS; REITER STEPHAN 摘要:The invention relates to novel catalysts for the synthesis of polyurethanes, represented by general formula (I) or (II), or compounds obtained by reacting a metal salt of the metals magnesium, calcium, yttrium, lanthanum, titanium, zirconium, manganese, iron, cobalt, zinc, aluminium, tin, comprising an anion from the group fluoride, chloride, bromide, sulphonate, trifluoromethanesulphonate, methanesulphonate, benzolsulphonate, para-toluenesulphonate, carboxy-C1-C10-alkyl, carboxy-C3-C10-cycloalkyl, carboxy- C2-C10-alkenyl, C1-C10-alkoxy, acetylacetonate, trifluoroacetlyacetonate or hexafluoroacetylacetonate, with N-heterocyclic compounds of general structure I; or with N-heterocyclic compounds of general structure II; or with N-heterocyclic compounds of general structure III.
专利号:US-7923226-B2 优先权日:2003-10-01 标题 :Synthesis of 1,2,4-butanetriol enantiomers from carbohydrates 发明人:FROST JOHN W 权利人:UNIV MICHIGAN STATE 摘要:A bioengineered synthesis scheme for the production of L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof from a carbon source is provided. Methods of producing L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof are also provided. Methods are also provided for converting D-1,2,4-butanetriol and L-1,2,4,-butanetriol to D,L-1,2,4-butanetriol trinitrate.
专利号:US-2011165641-A1 优先权日:2006-03-31 标 题 :Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates 发明人:FROST JOHN W 权利人:UNIV MICHIGAN STATE 摘要:A bioengineered synthesis scheme for the production of L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof from a carbon source is provided. Methods of producing L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof are also provided. Methods are also provided for converting D-1,2,4-butanetriol and L-1,2,4,-butanetriol to D,L-1,2,4-butanetriol trinitrate.
专利号:US-5756790-A 优先权日:1995-09-29 标题 :Optically active cobalt (II) complexes and method for the preparation of optically active alcohols 发明人:MUKAIYAMA TERUAKI; YOROZU KIYOTAKA; NAGATA TAKUSHI; YAMADA TORU; SUGI KIYOAKI 权利人:MITSUI PETROCHEMICAL IND 摘要:The invention provides a method for preparing an optically active alcohol comprising the step of reacting a ketone compound with a hydride reagent in the presence of an optically active metal compound. The resulting optically active alcohols are useful as intermediates for the synthesis of physiologically active compounds such as drugs and pesticides, functional materials such as liquid crystals, and raw materials for synthesis in fine chemistry. A novel optically active cobalt (II) complex useful as a catalyst is also provided.
专利号:US-6288244-B1 优先权日:1999-03-31 标 题 :Process for the preparation of 3, 4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars 发明人:HOLLINGSWORTH RAWLE I 权利人:UNIV MICHIGAN STATE 摘要:A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-γ-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic acid and (R)-3-hydroxy-γ-butyrolactone from a 3-leaving group substituted L-pentose sugars. The process uses a base and a peroxide to convert the pentose source to the chiral 3,4-dihydroxybutanoic acid compound. The chiral 3,4-dihydroxybutanoic acid can be further converted to 3-hydroxy-γ-butyrolactone by acidification. The chiral compound is useful as a chemical intermediate to the synthesis of various drugs and other products.
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合成参考文献
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