CAS: 24159-07-7; 3-(3-((2R,3S)-3-Hydroxypiperidin-2-yl)-2-Oxopropyl)Quinazolin-4(3H)-One
该化合物是一个化学化合物,其结构复杂,包括一个五氯硝基酮核心和一个管状松,具有各种疾病治疗的潜在作用.该化合物通常具有与其功能组有关的特性,例如由于存在氢氧基和安聚物,极地溶剂中的潜在溶解性.管状环有助于其基本性,而quinazolinone结构可能传播生物活动,使其对药用化学感兴趣.这种性质的化合物经常因其药理特性,包括作为酶抑制剂或治疗各种疾病的潜在作用而受到调查.由(2R,3S)配置显示的立体化学学表明可以影响化合物的生物相互作用和功效的具体空间安排.
- 英文名称3-(3-((2R,3S)-3-Hydroxypiperidin-2-yl)-2-Oxopropyl)Quinazolin-4(3H)-One
- 中文名称常山乙素
- IUPAC名称3-(3-((2R,3S)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one
- 其它别名(+)-Isofebrifugine; Febrifugine; 3-(3-(3-Hydroxypiperidin-2-yl)-2-Oxopropyl)Quinazolin-4(3H)-One; 3-[3-(3-Hydroxypiperidin-2-yl)-2-Oxopropyl]Quinazolin-4-One; .Beta.-Dichroine; Gamma-Dichroine
- CAS编号24159-07-7
- EINECS号:683-166-2
- FDA UNII编号:89UWD0FH2I
- 分子式:C16H19N3O3分子量:301.35
- 产品CID: 1187636
- 同类组份化合物CAS24159-07-7 (free base)32434-42-7 (2HCl)
- 产品分类生物化工 → 中草药成分
物理性质
- 熔点139-140°; mp 154-156°
- 沸点508.2±60.0 °C at 760 mmHg
- 闪点261.1±32.9 °C
- 密度1.4±0.1 g/cm3
- PH:D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol)
- pKa:14.61±0.40(预测)
- PSA:84.22
- LogP:-0.04
- 折射率1.673
- 蒸汽压0.0±1.4 mmHg at 25°C
- 溶解性DMF: 1.5 mg/mL; DMSO: 3.0 mg/mL; Ethanol: 0.1 mg/mL; Pbs (Ph 7.2): 2.5 mg/mL
- 外观形态白色至类白色结晶性固体
- 储存条件2-8°C
- 产品应用该化合物用作内容确定,识别和药理实验.
MSDS等安全信息
欧盟法规
C&L通报上下游产品
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📜(1R,2S,5S,7R)-7-[[tert-Butyl(Dimethyl)Silyl]Oxymethyl]-6,8-Dioxabicyclo[3.2.1]oct-3-En-2-Ol置于platinum(Iv) Oxide 吡啶,盐酸,氢氧化钾,Sodium Tetrahydroborate,四氧化锇,Lithium Aluminium Tetrahydride,Grubbs Catalyst First Generation,Sodium Azide,N-甲基吲哚酮,三丁基膦,四丁基氟化铵,氢气,双氧水,Sodium Hydride,Potassium Carbonate,溶剂黄146,三乙胺,Calcium Carbonate,Lithium Iodide,锌体系中,用 四氢呋喃,甲醇,二苯醚,乙醇,水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成常山乙素
参考文献:A Diastereocontrolled Synthesis Of (+)-Febrifugine: A Potent Antimalarial Piperidine Alkaloid
标题:A Diastereocontrolled Synthesis Of (+)-Febrifugine: A Potent Antimalarial Piperidine Alkaloid
摘要:[graphics]A Diastereocontrolled Synthesis Of (+)-Febrifugine,A Potent Antimalarial Piperidine Alkaloid,Has Been Achieved Using A Chiral Block Having A Bicyclo[3.2.1]octane Framework Which Exhibits Inherent Convex-Face Selectivity.
Doi:10.1021/ol006384F
海关参考信息
- 2902200000-苯
2905122000-异丙醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6844350-B2
优先权日:1999-03-01
标题:Febrifugine, isofebrifugine and method for producing the same
发明人：KOBAYASHI SHU; WATAYA YUSUKE; KIM HYE-SOOK
权利人:JAPAN SCIENCE & TECH CORP
摘要:A febrifugine represented by Formula (A): n n nand an isofebrifugine represented by Formula (B): n n nwhich exhibit extremely strong activities against tropical malarial protozoan are provided, together with a total synthesis route which enables efficient large scale synthesis of the same.
专利号:CN-104557738-A
优先权日:2014-12-23
标 题 :A kind of green synthesis method of 4(3H)-quinazolinone
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Smullen S, McLaughlin NP, Evans P. Chemical synthesis of febrifugine and analogues. Bioorg Med Chem. 2018 May 15;26(9):2199-2220. doi: 10.1016/j.bmc.2018.04.027. Epub 2018 Apr 12. 22(7):1993-2004. doi: 10.1016/j.bmc.2014.02.040. Epub 2014 Mar 1.
48:42. doi: 10.1186/s41182-020-00230-x.
4: Pandey RK, Ojha R, Devender M, Sebastian P, Namdeo M, Kumbhar BV, Sundar S, Maurya R, Prajapati VK. Febrifugine dihydrochloride as a new oral chemotherapeutic agent against visceral leishmaniasis infection. Exp Parasitol. 2022 May-Jun;236-237:108250. doi: 10.1016/j.exppara.2022.108250. Epub 2022 Apr 4. 20(2):927-32. doi: 10.1016/j.bmc.2011.11.053. Epub 2011 Dec 2.
合成参考文献
摘要:Nature., 161(400), 1948
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