CAS: 21803-75-8; 4-Amino-3-Chlorobenzonitrile

相似化合物

34662-29-8 2486-71-7 50961-67-6

上下游产品

4-Aminobenzonitrile N-(2-chloro-4-cyanophenyl)acetamide 1-chloro-5-cyano-2-nitrobenzene 1-chloro-5-cyano-2-nitrobenzene 4-benzothiazol-2-yl-2-chlorophenylamine 4-amino-3-chlorobenzoic acid 4-[4-(butyl-ethyl-amino)-6-methyl-3-nitro-pyridin-2-ylamino]-3-chloro-benzonitrile

📜对氨基苯腈置于iron(III) Chloride,N-氯代丁二酰亚胺,1-丁基-3-甲基咪唑二(三氟甲基磺酰)酰亚胺体系中,用 四氢呋喃 用作溶剂,化学反应 24.0H,以93%的收率获得4-氨基-3-氯苯甲腈
参考文献:铁(III)催化的芳烃氯化反应
标题:铁(III)催化的芳烃氯化反应
摘要:已经开发了用于活化的芳烃氯化的通用的和区域选择性的方法.该转化过程使用三氟甲磺酸铁(III)作为强力的路易斯酸来活化n-氯代琥珀酰亚胺和随后的氯化过程,将各种苯甲醚,苯胺,对乙酰苯胺和苯酚衍生物进行氯化.该反应用于一系列目标化合物的后期单氯化和二氯化反应,这些目标化合物例如是天然产物硝苯芬净,抗菌剂氯氧lenol和除草剂氯己腈.一锅,串联,铁催化的二卤化过程的发展证明了这种转变的简便性,可以高度区域选择性地形成不同的碳-卤键.通过合成天然产物和药物相关靶标,建立了所得二卤代芳基化合物作为结构单元的合成效用.
Doi:10.1021/acs.Joc.7B01225

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:US-4257942-A
优先权日:1977-10-06
标题:New water-insoluble azo dyes
发明人：DEFEO FRANCESCO; CIPOLLI ROBERTO
权利人:ACNA
摘要:The present invention relates to the synthesis of new dyes having the following general formula: wherein: D is the residue of a diazotizable component of the carbocyclic or heterocyclic series X is an ethylene group, optionally substituted by halogen-methyl, alkyl C1-C4, aryl, aralkyl or CH2OCO(HN)nR (wherein R and n have the meanings hereinafter defined); R is alkyl C1-C8 optionally substituted by halogen, CN,COOH; aryl optionally substituted by one or more atoms of halogen, alkyl C1-C4, alkoxyl C1-C4; alkoxyl C1-C4; alkoxyl C1-C8; Aryloxy; aralkoxy; cycloalkoxy; aralkyl; naphthyl optionally substituted by halogen; alkenyl C2-C8, optionally substituted by halogen, CN, COOH; R1 and R2, either like or unlike each other, may be alkyl C1-C4 optionally substituted by halogen or CN groups; aralkyl; R3 is H; halogen, alkyl C1-C4; alkoxyl C1-C4, optionally substituted. n is 0 or 1.

专利号:US-2016046560-A1
优先权日:2013-04-05
标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:WO-2014165816-A1
优先权日:2013-04-05
标 题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:US-4411912-A
优先权日:1978-02-16
标 题 :Insecticidal isovaleric acid esters
发明人：HENRICK CLIVE A; GARCIA BARBARA A
权利人:ZOECON CORP
摘要:Esters and thiolesters of amino acids, intermediates therefor, synthesis thereof, and the use of said esters and thiolesters and compositions for the control of pests.