CAS: 2113-68-0; [1,1'-Biphenyl]-4-Sulfonic Acid

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CAS号92-52-4 联苯 | CAS号98-80-6 苯硼酸 | CAS号19813-90-2 联苯-4-硫醇 | CAS号92-69-3 4-苯基苯酚 | CAS号2051-62-9 4-氯联苯 | CAS号1623-93-4 对联苯磺酰氯

📜联苯置于氯磺酸体系中,用 氯仿 用作溶剂,化学反应生成联苯-4-磺酸
参考文献:一系列有效的,系统可用的联苯磺酰胺基质金属蛋白酶抑制剂的结构活性关系和药代动力学分析.
标题:一系列有效的,系统可用的联苯磺酰胺基质金属蛋白酶抑制剂的结构活性关系和药代动力学分析.
摘要:制备了一系列(S)-2-(联苯基-4-磺酰基氨基)-3-甲基丁酸(5)的联苯磺酰胺衍生物,并评估了它们抑制基质金属蛋白酶(mmps)的能力.对于这一系列化合物,我们的目标是用结构上不同的功能性系统取代取代基上5的联苯和α-位置的取代基,以评估这些变化对生物学和药代动力学活性的影响.随后的结构活性关系(sar)研究表明,在4'-位(11C)处被溴取代的联苯磺酰胺显着提高了体外活性,并显示出优异的药代动力学(c(max),T(1/2),Aucs,相对于化合物5而言,可以通过用各种取代基取代11C的异丙基来改变α位的亲脂性,一般而言,与mmp-2,-3和-13相比,药效保持不变,但口服系统利用率较低.随后对其对映异构体11C'的评估表明,两种化合物都是同等有效的mmp抑制剂.相反,相应的异羟肟酸对映体对16A(s-异构体)和16A'(r-异构体)立体选择性抑制了mmp.在该系列中,16A'首次提
Doi:10.1021/jm9903141

专利信息

专利号:WO-2024126092-A1
优先权日:2022-12-14
标题:Method for producing 5-hmf by converting a syrup in a non-aqueous solvent with extraction of the syrup water upstream of the synthesis
发明人：BOURAS MERIEM; DANG THI BICH NGOC; FERNANDEZ ESPADA PASTOR MARIA; LORCET HÉLÈNE; PAGOT ALEXANDRE; BREUIL PIERRE-ALAIN
权利人:IFP ENERGIES NOW
摘要:The present invention relates to a method for producing a 5-hydroxymethylfurfural (5-HMF) solution, comprising a step a) of bringing a feedstock comprising a hexose into contact with a synthesis solvent and an acid dehydration catalyst, said step being performed at a temperature of between 30 and 200°C, preferably between 50 and 180°C, more preferably between 70 and 150°C and very preferably between 90 and 130°C, and at a pressure of between 0.001 MPa and 10 MPa, preferably between 0.001 MPa and 5 MPa, more preferably between 0.01 MPa and 1 MPa, obtaining a reaction medium and concomitantly extracting the water from the reaction medium, in order to obtain a synthesis effluent comprising 5-HMF and synthesis solvent.

专利号:WO-2025087830-A1
优先权日:2023-10-25
标 题:Production of 5-hmf in a non-aqueous solvent, with concentration of the 5-hmf prior to liquid-liquid extraction
发明人：JACQUIN MARC; PAGOT ALEXANDRE
权利人:IFP ENERGIES NOW
摘要:The invention relates to a process for producing 5-hydroxymethylfurfural (5-HMF), comprising, in succession: a) bringing a sugar feedstock into contact with a polar aprotic synthesis solvent and an acid dehydration catalyst, at a temperature of 30-200°C and a pressure of 0.001-10 MPa, in order to produce a synthesis effluent that includes 5-HMF; b) concentrating the 5-HMF in the synthesis effluent; c) bringing the concentrated synthesis effluent into contact with an aqueous stream; d) liquid-liquid extraction with an organic extraction solvent, followed by a step e) of backwashing with an aqueous solvent in order to obtain an organic raffinate rich in 5-HMF and in solvent. The optionally concentrated organic raffinate is then subjected to a purification step g), for example hydrodistillation or crystallisation, in order to obtain a 5-HMF stream, for example in the form of an aqueous 5-HMF solution or crystalline 5-HMF.

专利号:WO-2024126091-A1
优先权日:2022-12-14
标 题:Method for producing 5-hmf via conversion of sugar in a non-aqueous solvent with water extraction during synthesis
发明人：BOURAS MERIEM; DANG THI BICH NGOC; FERNANDEZ ESPADA PASTOR MARIA; LARMIER KIM; LORCET HÉLÈNE; PAGOT ALEXANDRE
权利人:IFP ENERGIES NOW
摘要:The present invention relates to a method for producing a solution of 5-hydroxymethylfurfural (5-HMF), the method comprising a step a) of bringing a feedstock comprising a hexose into contact with a synthesis solvent and a dehydration acid catalyst, carried out at a temperature of between 30 and 200°C, preferably between 50 and 180°C, more preferably between 70 and 150°C and very preferably between 90 and 130°C, and at a pressure of between 0.001 MPa and 10 MPa, preferably between 0.001 MPa and 5 MPa, and more preferably between 0.01 MPa and 1 MPa, obtaining a reaction medium and concomitantly extracting the water from the reaction medium, to obtain a synthesis effluent comprising 5-HMF and synthesis solvent.

专利号:WO-2023232427-A1
优先权日:2022-05-31
标 题:Synthesis of levulinic acid by hydration of furfuryl alcohol in the presence of a homogeneous acid catalyst and of a solvent based on ether and/or acetals

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-3442857-A
优先权日:1965-11-10
标题 :Boron trifluoride-hydrogen fluoride catalyzed synthesis of poly(aromatic sulfone) and poly(aromatic ketone) polymers
发明人：THORNTON ROGER L
权利人:DU PONT