CAS: 19793-20-5; 19-Nor-Androst-4-Ene-3β,17β-Diol

该化合物是属于二醇类别的化学化合物,其特点是存在两种氢氧(-OH)功能组,这种物质一般无色,在室温下可能呈现粘性液体状态.Bolandiol因其作为较复杂分子的构件的能力而在各个领域,包括制药和聚合化学领域的潜在应用而闻名.它的化学结构允许氢结合,这可能影响其溶解性和再活动.此外,Bolandiol可以参与凝聚反应,使其在合成多元醇和其他衍生物时有用.在处理和储存准则方面,应参考安全数据表,如任何化学物质,以确保安全使用和遵守管制标准.

结构式图片

上下游产品

诺龙 19-Nortestosterone 434-22-0
19-去甲睾酮乙酸酯 19-Nortestosterone Acetate 1425-10-1

合成工艺路线路线简述

    诺龙置于sodium Tetrahydroborate体系中,用 1,4-二氧六环 用作溶剂,化学反应生成19-去甲基-4-雄烯二醇
    参考文献:Metabolism Of 19-Nortestosterone By Human Prostate
    标题:Metabolism Of 19-Nortestosterone By Human Prostate
    摘要:
    Doi:10.1016/0039-128X(66)91012-9

    海关参考信息

    专利信息


    专利号:US-2014274978-A1
    优先权日:2013-03-15
    标题 :Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals
    发明人:FASCIOLA ANDRE ARMEL
    权利人:FASCIOLA ANDRE ARMEL
    摘要:The present invention utilizes phytosterol, phytoecdysteroid, sapogenin, triterpene, terpene, spirostane, spirostene and androstene derivative compounds to provide a wide variety of utilities to humans and other animals. The compounds and methods provide numerous and wide-ranging benefits including biochemical and constructive metabolic benefits including increases in protein synthesis and synthesis efficiency, ergogenic, adaptogenic, cosmetic and medicinal skin agents and veterinary utilities. The compounds provide agents that increase physical endurance and work output, act as a general tonic for increasing health and vigor, increase sleep time and sleep efficiency and act as rejuvenating agents to reverse the effects of fatigue and stress. Novel utilities for pet, farm, zoo and companion animals are also provided.

    专利号:FR-2414515-A1
    优先权日:1978-01-11
    标 题 :STEROIDS TRADEMARKS WITH TRITIUM, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE SYNTHESIS OF ESTRANE DERIVATIVES TRITIUM TRADEMARKS

    专利号:US-2025281509-A1
    优先权日:2021-04-26
    标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer
    发明人:DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER
    权利人:UNIV JOHNS HOPKINS
    摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.
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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:21 CFR Sections 1308.11-1308.15
    参考文献:10.1111/j.2047-2927.2012.00006.x
    摘要:Otto‐Duessel M, He M, Adamson TW, Jones JO. Enhanced evaluation of selective androgen receptor modulators in vivo. Andrology. 2012 Aug 28;1(1):29–36. doi: 10.1111/j.2047-2927.2012.00006.x.
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