CAS: 151062-55-4; (S)-2-Amino-3-Mercapto-2-Methylpropanoic Acid Hydrochloride

相似化合物

10318-18-0 32443-99-5 52-89-1

专利信息

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:US-2003236435-A1
优先权日:2002-05-15
标题 :Synthesis of 2-alkylcysteine via substituted thiazoline ester

专利号:US-2004002613-A1
优先权日:2002-05-15
标 题 :Synthesis of benzonitriles from substituted benzoic acid

专利号:US-2003225287-A1
优先权日:2002-05-15
标 题:Synthesis of chiral 2-alkyl amino acids

专利号:US-2003229231-A1
优先权日:2002-05-15
标题:Synthesis of 2-alkylcysteine

专利号:US-2003236404-A1
优先权日:2002-05-15
标题 :Synthesis of 2-alkylcysteine via phase transfer catalysis