CAS: 144701-20-2; 2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)Hexanoic Acid

相似化合物

112883-41-7 112883-42-8 15027-14-2

上下游产品

2-N-fluorenylmethoxycarbonylaminohex-4-enoic acid (fluorenylmethoxy)carbonyl chloride L-Norleucine 2-amino-hexanoic acid

📜Dl-正亮氨酸,9-芴甲基-N-琥珀酰亚胺基碳酸酯置于phosphate Buffer体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,反应生成N-芴甲氧羰基-Dl-正亮氨酸
参考文献:Novel Selective Inhibitors Of The Interaction Of Individual Nuclear Hormone Receptors With A Mutually Shared Steroid Receptor Coactivator 2
标题:Novel Selective Inhibitors Of The Interaction Of Individual Nuclear Hormone Receptors With A Mutually Shared Steroid Receptor Coactivator 2
摘要:Nuclear Hormone Receptor (Nr) Signaling,Currently A Therapeutic Target In Multiple Diseases,Involves An Ordered Series Of Protein Interactions To Regulate Transcription In Response To Changing Hormone Levels. Later Steps In The Process Of Ligand-Dependent Signaling Are Driven By A Highly Conserved Interaction Between The Nrs And The Steroid Receptor Coactivators (Srcs) That Is Effected By A Conserved Interaction Motif (L1Xxl2L3),Known As An Nr Box. Using Computational Design And Combinatorial Chemistry,We Have Produced Novel Alpha-Helical Proteomimetics Of The Second Nr Box Of Src2 That Exploit Structural Differences Between Human Estrogen Receptor Alpha (Heralpha),Human Estrogen Receptor Beta (Herbeta),And Human Thyroid Hormone Receptor Beta (Htrbeta). The Resulting Library Sequentially Replaced Each Leucine With Non-Natural Side Chains. Screening This Library Using A Quantitative Competition Assay Revealed Compounds That Selectively Inhibit The Interaction Of Src2-2 With Each Individual Nr In Preference To Its Interaction With The Other Nr. This Approach Generated Highly Selective Compounds From One That Had No Specificity For A Particular Family Member. These Compounds Represent The First Family-Member-Selective Competitive Inhibitors Of The Protein Interactions Of Transcription Factors.
Doi:10.1021/ja0348391

专利信息

专利号:US-2023295077-A1
优先权日:2020-04-10
标题:An improved process for the preparation of semaglutide side chain
发明人：PANDEY MANEESH KUMAR; SHUKLA SONU PRASAD; NAIN SACHIN; SANDEEP SANDEEP; MALE SRIDHAR; SOKHI SARBJOT SINGH; SINGH GOVIND; LAHIRI SASWATA; CABRI WALTER
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the preparation of a compound of Formula (1), The invention also provides improved processes for the preparation of intermediates used in the synthesis of Formula (1). The compound of Formula (1) is used in the synthesis of Semaglutide.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:CN-110776555-A
优先权日:2019-11-28
标 题 :A class of bifunctional D-amino acid modified opioid peptides and their synthesis methods and applications