CAS: 130-26-7; 5-Chloro-7-Iodoquinolin-8-Ol

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130-16-5 57334-36-8 773-76-2

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CAS号130-16-5 5-氯-8-羟基喹啉 | CAS号27037-46-3 5-chloro-7-iodo... | CAS号1371439-48-3 5-chloro-7-iodo... | CAS号148-24-3 8-羟基喹啉 | CAS号220819-20-5 1-(5-chloro-7-i... | CAS号7647-01-0 盐酸 | CAS号7732-18-5 水 | CAS号773-76-2 5,7-二氯-8-羟基喹啉 | CAS号83-73-8 双碘喹啉 | CAS号130-16-5 5-氯-8-羟基喹啉 | CAS号17012-44-1 5-氯-8-甲氧基喹啉 | CAS号73511-39-4 ethyl 2-(5-chlo... | CAS号73511-41-8 (5-氯-7-碘喹啉-8-氧基)-乙酸肼

5-氯-7-碘喹啉-8-基乙酸酯置于sodium Hydroxide体系中,化学反应生成氯碘羟喹
参考文献:Nonreductive Deiodination Of Ortho-Iodo-Hydroxylated Arenes Using Tertiary Amines
标题:Nonreductive Deiodination Of Ortho-Iodo-Hydroxylated Arenes Using Tertiary Amines
摘要:[graphic]A Convenient And Nonreductive Deiodination Is Reported For The Ortho-Iodo-Hydroxylated Arenes Inch,Ding Derivatives Of Quinolinol,Phenol,And Naphthol. Tertiary Amines Pyridine,Triethylamine,And N-Methylmorpholine In The Presence Of Water Initiated Deiodination Of Ortho-Iodo-Hydroxylated Arenes Without Affecting Para-Iodine And Other Reduction-Susceptible Groups. This Reported Method Also Works Efficiently For Polyiodinated Systems. Simplicity,Short Reaction Times,And Absence Of Reducing Catalyst Are Features Of This Method.
Doi:10.1021/jo051191X

专利信息

专利号:US-9481649-B2
优先权日:2009-08-24
标题 :Synthesis of a neurostimulative piperazine
发明人：VENKATRAMAN SRIPATHY; MAHMOOD SYED; MOBELE BINGIDIMI I; LAPINA OLGA; VERCOE KELLIE; LI YING; SALSBURY JONATHAN; MCLAWS MARK
权利人:NEURALSTEM INC
摘要:The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.

专利号:US-2005239808-A1
优先权日:2002-05-10
标题 :Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur
发明人：SCHRADER THOMAS; RIESNER DETLEV; RZEPECKI PETRA; NAGEL-STEGER LUITGARD; WEHNER MARK; KIRSTEN CHRISTIAN; MOLT OLIVER; ZADMARD REZA; ASCHERMANN KATJA
权利人:SCHRADER THOMAS; RIESNER DETLEV; RZEPECKI PETRA; NAGEL-STEGER LUITGARD; WEHNER MARK; KIRSTEN CHRISTIAN; MOLT OLIVER; ZADMARD REZA; ASCHERMANN KATJA
摘要:The invention on hand refers to diseases associated with abnormal protein structures, including Alzheimer's disease, Creutzfeldt-Jakob's disease, BSE and other prion-associated diseases. It is the task of the invention on hand to provide new active agents preventing the formation of amyloid plaques and to dissolve existing plaques, such agents being convenient for therapy, diagnosis and prophylaxis of diseases that are associated with abnormal protein structures. This task is performed in terms of the current invention by heterocyclic or aromatic agents with a rigid structure and a donor-acceptor-donor pattern (DAD), the latter being formed by donors and acceptors of hydrogen bridge linkages which comply with the β-sheet structure of the peptide or protein and thus fit as binding partners. The heterocyclic or aromatic agents are available at least as dimers. They recognise peptides and proteins with a β-sheet structure, form stable complexes with them and inhibit their aggregation to β-amyloid plaques. Furthermore, the new active agents are able to dissolve β-amyloid plaques that already exist. Another task of the current invention is to provide methods for the synthesis of said heterocyclic or aromatic compounds.

专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人：BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:US-10287265-B2
优先权日:2015-03-09
标 题 :Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof
发明人：Puskás László; Kanizsai István; PILLOT THIERRY; GYURIS Márió; Szabó András; Takács Ferenc; Hackler László
权利人:AVIDIN CO LTD; SONEAS RES CO LTD; SYNAGING SAS
摘要:Our invention relates to novel enantiomer derivatives of 8-hydroxyquinoline derivatives with general formula (I) and (II) and the synthesis thereof and pharmaceutically acceptable salts and metal complexes thereof, and the medicinal and/or pharmaceutical compositions comprising these compounds. n n n n n n n n n n The essence of the subject matter of the invention relates to the fact that prior art discloses the biological effect and characteristics only of the racemic products, the novel enantiomer derivatives according to the invention appear in our application for the first. n The subject matter of the invention furthermore relates to a novel, stereoselective synthesis for the preparation of the novel enantiomer derivatives according to the invention. The novel medicinal and/or pharmaceutical compositions comprising these enantiomers are suitable for the treatment of the named diseases, and the enanatiomers are used for manufacture of these compositions. These applications for manufacture of the compositions are also the subject matters of the invention. The compounds according to the invention can be used preferably as cytoprotective, neuroprotective, cardioprotective, anxiolytic and antidepressant agent for treatment of neuropsychiatric and neurologic diseases and diseases in connections with transplantations and with ischemia and reperfusion injuries thereof, and inhibition of organ, advantageously skin graft rejection. According to our studies the R-enantiomer has either sole or high biological effect in some cases.

专利号:US-2009325858-A1
优先权日:2003-03-21
标 题:Reduction of Zinc-Induced Neurotoxic Injury By Blockade of Nitric Oxide Synthesis
发明人：FREDERICKSON CHRISTOPHER J
权利人:ANDRO DIAGNOSTICS INC
摘要:The present invention provides methods of inhibiting release of zinc from neurons and of preventing zinc-mediated brain injury. Also provided are methods of improving cerebral blood flow while preventing zinc-mediated brain injury. Inhibitors of or activators of nitric oxide synthases modulate nitric oxide synthesis to reduce nitric oxide-induced release of neurotoxic amounts of zinc, thereby reducing zinc-mediated neuronal injury after brain trauma.

专利号:CN-101067135-A
优先权日:2000-02-11
标题 :Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents