CAS: 1273564-99-0; 3,3-Difluorocyclobutanone

相似化合物

637031-88-0 23761-24-2 175021-13-3

📜3,3-二氟环丁醇置于pyridinium Chlorochromate体系中,用 二氯甲烷 用作溶剂,以39%的收率获得3,3-二氟环丁酮
参考文献:C4 / C5 3,3-二氟环丁基取代的结构单元的多重图合成
标题:C4 / C5 3,3-二氟环丁基取代的结构单元的多重图合成
摘要:摘要 描述了一种3,3-二氟环丁基取代的结构单元(包括羧酸,胺,醇,叠氮化物,三氟硼酸酯)的多谱图合成方法.结果表明,在大多数情况下,3,3-二氟环丁烷甲酸乙酯是获得目标衍生物的方便的常用合成中间体.为了制备3,3-二氟环丁醇或-环丁酮,应采用通过二氯乙烯酮与叔丁基或苄基乙烯基醚反应的替代途径. 描述了一种3,3-二氟环丁基取代的结构单元(包括羧酸,胺,醇,叠氮化物,三氟硼酸酯)的多谱图合成方法.结果表明,在大多数情况下,3,3-二氟环丁烷甲酸乙酯是获得目标衍生物的方便的常用合成中间体.为了制备3,3-二氟环丁醇或-环丁酮,应采用通过二氯乙烯酮与叔丁基或苄基乙烯基醚反应的替代途径.
Doi:10.1055/s-0037-1610237

专利信息

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:US-2025276972-A1
优先权日:2020-12-15
标 题:Compounds as casein kinase inhibitors
发明人：Zhou Enxing; LIU YUAN; WANG HANPING; WU GUANGLONG; SHAO NING
权利人:GRITSCIENCE BIOPHARMACEUTICALS CO LTD
摘要:Provided are casein kinase inhibitors, or pharmaceutically acceptable salts thereof. Corresponding pharmaceutical compositions, methods of synthesis, and intermediates are also provided.