CAS: 123618-00-8; Fedotozine
该化合物是一种化学化合物,属于被称为选择性血清素再摄入抑制剂的药物类别,主要被确认为在治疗胃肠紊乱,特别是肠胃炎综合征(IBS)中的潜在用途.该化合物具有5-HT3受体抗体的作用,有助于调节肠胃运动和缓解与IBS有关的症状.Fedotozine表现出相对较低的毒性特征,其特点是它能够影响肠胃血清素水平,从而影响情绪和消化功能.其药理特性包括抗乳效应,使其在管理恶心和呕吐方面有用.该化合物在临床环境中的功效和安全性已经研究过,尽管它可能并非在所有地区都能广泛获得.与任何制药剂一样,其具体特征,包括其溶性,稳定性和与其他药物的互动性,对于治疗应用至关重要,应在临床实践中加以考虑.
- 英文名称Fedotozine
- 中文名称费朵托嗪
- IUPAC名称(R)-N,N-dimethyl-2-phenyl-1-((3,4,5-trimethoxybenzyl)oxy)butan-2-amine
- 其它别名Fedotozine; [r,(+)]-1-Phenyl-1-[(3,4,5-Trimethoxybenzyl)Oxymethyl]-N,N-Dimethylpropan-1-Amine; Benzenemethanamine, α-Ethyl-N,N-Dimethyl-α-[[(3,4,5-Trimethoxyphenyl)Methoxy]Methyl]-, (αr)-
- CAS编号123618-00-8
- MFCD编号:MFCD00867433
- FDA UNII编号:F45VW2087W
- 分子式:C22H31NO4分子量:373.49
- 产品CID: 340678
- 产品分类有机原料 → 苯类化合物 → 苯取代衍生物
物理性质
MSDS等安全信息
上下游产品
2-二甲基氨基-2-苯基丁-1-醇 2-Phenyl-2-Dimethylamino-1-Butanol 39068-94-5合成工艺路线路线简述
📜2-二甲基氨基-2-苯基丁-1-醇,3,4,5-三甲氧基苄氯 反应生成费朵托嗪
参考文献:Drugs. Fut. 1992,17,101
标题:Drugs. Fut. 1992,17,101
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905121000-正丙醇
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专利信息
专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.
专利号:US-9597327-B2
优先权日:2005-05-25
标 题:Synthesis of (R)-N-methylnaltrexone
发明人：DOSHAN HAROLD D; PEREZ JULIO
权利人:PROGENICS PHARM INC
摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
专利号:US-7501434-B2
优先权日:2006-08-04
标 题 :6-carboxy-normorphinan derivatives, synthesis and uses thereof
发明人：SHAH SYED M; ALI KADUM A; KONG FANGMING; ZHU TIANMIN; GOMBAR CHARLES T
权利人:WYETH CORP
摘要:The present invention relates to compounds of formula I, synthesis thereof, and methods of using the same.
专利号:US-7674904-B2
优先权日:2005-05-25
标 题 :Synthesis of R-N-methylnaltrexone
专利号:US-2007099946-A1
优先权日:2005-05-25
标 题:Synthesis of R-N-methylnaltrexone
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1. Delvaux M. Pharmacology and clinical experience with fedotozine. Expert Opin Investig Drugs. 2001 Jan;10(1):97-110. doi: 10.1517/13543784.10.1.97. 42(8):546-52. doi: 10.1111/j.2042-7158.1990.tb07056.x.合成参考文献
参考文献:10.1007/s001080050368
摘要:Müller-Lissner SA, Klauser AG. [Functional abdominal complaints. Functional dyspepsia and irritable colon]. Internist (Berl). 1999 May;40(5):543–54. doi: 10.1007/s001080050368.
参考文献:10.1053/gast.1999.0029900388
摘要:Ness TJ. Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distention. Gastroenterology. 1999 Aug;117(2):388–94. doi: 10.1053/gast.1999.0029900388.
参考文献:10.1002/j.1536-4801.2004.tb12265.x|10.1097/00005176-200406003-00024
摘要:Camilleri M. Advances in Pharmacological Treatments of IBS. Journal of Pediatric Gastroenterology and Nutrition. 2004 Jun;39(Supplement 3):S766–7. doi: 10.1097/00005176-200406003-00024.
摘要:Adami M, Bertaccini G, Roncoroni L, Cobianchi F. Effect of fedotozine on human distal colon. Ital J Gastroenterol. 1996 Oct;28(8):441–6.
📝 需求与反馈
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