CAS: 1219168-18-9; 6-(4-(2-(Piperidin-1-yl)Ethoxy)Phenyl)-3-(Pyridin-4-yl)Pyrazolo[1,5-A]Pyrimidine Dihydrochloride
该化合物是一个小分子,有选择地抑制AMP-活性蛋白质动脉(AMPK)路径,该化合物的特点是能够调节细胞能量的全息状态,并研究其在代谢紊乱和癌症中的潜在治疗用途.Dorsoorphin通常作为盐类出现,它能增强水溶液的溶解性,使之适合生物分析.该化合物的分子重量相对较低,并拥有一种特定的化学结构,使其能够有选择地与AMPK进行互动,从而影响各种代谢过程.在研究中,Dorsomorphin被用来调查AMPK在细胞信号,能源代谢和葡萄糖软化管方面的作用.其药理学特性和行动机制继续得到探讨,突出其在生物化学和药理学领域的重要性.
- 英文名称6-(4-(2-(Piperidin-1-yl)Ethoxy)Phenyl)-3-(Pyridin-4-yl)Pyrazolo[1,5-A]Pyrimidine Dihydrochloride
- 中文名称6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-a]嘧啶二盐酸盐
- IUPAC名称6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine dihydrochloride
- CAS编号1219168-18-9
- MFCD编号:MFCD11112197
- FDA UNII编号:TD4NBA239W
- 分子式:C24H27Cl2N5O分子量:472.42
- 产品CID: 306714
- 同类组份化合物CAS1219168-18-9 (2HCl)866405-64-3 (free base)
- 产品分类Inhibitors/Agonists → PI3K/Akt/mTOR → AMPK | Inhibitors/Agonists → Stem Cells/Wnt → TGF-beta Receptor | Inhibitors/Agonists → Autophagy → Autophagy
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2922110001-单乙醇胺
2922192100-二甲氨基乙醇
2922192210-2-二乙氨基乙醇
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-112870358-A
优先权日:2019-11-29
标 题:Use of deubiquitinase USP20 in reducing cholesterol synthesis and improving metabolic syndrome
专利号:CN-112870358-B
优先权日:2019-11-29
标 题:Use of deubiquitinase USP20 for reducing cholesterol synthesis and improving metabolic syndrome
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Valizadeh-Arshad Z, Shahbazi E, Hashemizadeh S, Moradmand A, Jangkhah M, Kiani S. In Vitro Differentiation of Neural-Like Cells from Human Embryonic Stem Cells by A Combination of Dorsomorphin, XAV939, and A8301. Cell J. 2018 Jan;19(4):545-551. doi: 10.22074/cellj.2018.4232. Epub 2017 Nov 4.
2: Łabuzek K, Liber S, Gabryel B, Bułdak Ł, Okopień B. Erratum to: Ambivalent effects of compound C (dorsomorphin) on inflammatory response in LPS-stimulated rat primary microglial cultures. Naunyn Schmiedebergs Arch Pharmacol. 2017 Mar;390(3):327-328. doi: 10.1007/s00210-017-1348-5. doi: 10.1016/j.jvs.2016.03.462. Epub 2016 Jun 30.
4: Madhu V, Dighe AS, Cui Q, Deal DN. Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells. Stem Cells Int. 2016;2016:1035374. doi: 10.1155/2016/1035374. Epub 2015 Dec 20.
合成参考文献
参考文献:10.1177/09603271251323753
摘要:Wang J, Yang JH, Xiong D, Chen L. Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma. Hum Exp Toxicol. 2025 Jan;44():9603271251323753. doi: 10.1177/09603271251323753.
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