CAS: 117007-52-0; 3-Iodo-1H-Pyrazolo[3,4-B]Pyridine

相似化合物

1350653-23-4 1352396-72-5 875781-18-3

上下游产品

CAS号271-73-8 1H-吡唑并[3,4-b]吡啶 | CAS号36404-88-3 2-氯-3-吡啶甲醛 | CAS号6602-54-6 2-氯烟腈 | CAS号6752-16-5 3-氨基-1H-吡唑并[3,4-b]吡啶 | CAS号63682-46-2 1H-Pyrazolo[3,4... | CAS号875781-18-3 5-溴-3-碘-1H-吡唑并[... | CAS号916326-31-3 1-B°C-5-溴-3-碘-1... | CAS号920036-34-6 叔丁基-3-碘吡唑并[3,4-... | CAS号956010-88-1 1H-吡唑并[3,4-B]吡啶-3-甲腈

📜3-氨基-1H-吡唑并[3,4-B]吡啶置于三氟化硼乙醚,亚硝酸异戊酯,碘化钠体系中,用 四氢呋喃,丙酮 用作溶剂,以39%的收率获得3-碘-1H-吡唑并[3,4-B]吡啶
参考文献:3-(三氟甲基)-1 H-吡唑并-[3,4-B ]吡啶作为通用构件的用途
标题:3-(三氟甲基)-1 H-吡唑并-[3,4-B ]吡啶作为通用构件的用途
摘要:描述了使用定向邻位金属化(dom)技术从2-氟吡啶开始的一锅法合成3-(三氟甲基)-1 H-吡唑并[3,4-B ]吡啶的方法.该化合物包含可阴离子活化的三氟甲基,是用于微波辅助合成3取代的1 H-吡唑并[3,4-B ]吡啶的通用结构单元.
Doi:10.1016/j.Tet.2015.06.050

专利信息

专利号:US-8957210-B2
优先权日:2011-12-12
标题:Method for synthesizing 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-formamidine hydrochloride
发明人：LI JIN; YANG XIAOYU; ZHU JINGWEI; YANG MINMIN; WU XIHAN
权利人:PHARMABLOCK NANJING R & D CO LTD
摘要:The present invention relates to the field of chemical synthesis, and in particular to a method for synthesizing 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride, which is an important intermediate of Riociguat that is an anti-thromboembolic-disease medicine. The method is characterized in that: 3-iodo-1H-pyrazolo[3,4-b]pyridine is used as a raw material; the raw material is reacted with fluorobenzyl bromide to form a compound (10); the compound (10) is reacted with zinc cyanide to form a compound (6); the compound (6) is reacted with sodium methoxide, ammonium chloride, acetic acid and methanol to form a compound (8); and the compound (8) is reacted with chlorine hydride gas to form 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride. The method has the characteristics of cheap and readily available raw materials, high yield, mild reaction conditions and the like, and is a synthesis method having a large-scale preparation value.

专利号:US-7541367-B2
优先权日:2005-05-31
标 题 :3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
发明人：CHIU GEORGE; CONNOLLY PETER J; EMANUEL STUART; HUANG SHENLIN; LI SHENGJIAN; LIN RONGHUI; LU YANHUA; MIDDLETON STEVEN A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.