专利号:US-11746364-B2 优先权日:2018-01-17 标题 :Enzymatic synthesis of kavalactones and flavokavains 发明人:PLUSKAL TOMÃ?S; Weng jing-ke 权利人:WHITEHEAD INST BIOMEDICAL RES 摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-6600001-B1 优先权日:2002-01-11 标 题:Alkylamino oxamides as low odor, non-fugitive catalysts for the production of polyurethanes 发明人:GERKIN RICHARD M; ROBINSON KARENA KAYE; DERERIAN EDMOND J 权利人:CROMPTON CORP 摘要:A process for the synthesis of polyurethanes is disclosed wherein the process comprises reacting polyurethane-forming reactants in the presence of an effective amount of a catalyst comprising at least one alkylamino oxainide of the structure:wherein:R1 and R2 are independently selected alkyl groups or can be taken together to form a five or six-membered heterocyclic ring;R3 and R4 are independently selected from the group consisting of hydrogen and alkyl;n is 2 or 3;x is 0 or 1;Y is selected from the group consisting of O and NR9, wherein:R9 is selected from the group consisting of hydrogen and alkyl; andX is selected from the group consisting of OR10 and G, wherein:R10 is selected from the group consisting of hydrogen and alkyl; andG is
专利号:US-2017266353-A1 优先权日:2014-05-13 标 题:Bioadhesive compounds and methods of synthesis and use 发明人:MURPHY JOHN L; RADANO CHRISTOPHER P; DALSIN JEFFREY L; KOEPSEL JUSTIN T 权利人:DSM IP ASSETS BV 摘要:Synthesis methods for creating polymeric compounds comprising phenyl derivatives (PD), or PDp i.e., polymers modified with PD, with desired surface active effects are described. The polymer backbone of PDp has structural or performance features that can be tailored to control physical properties of PDp, allowing it to be useful for different applications i.e., tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.
专利号:US-2019271015-A1 优先权日:2018-01-17 标题 :Enzymatic synthesis of kavalactones and flavokavains
专利号:US-2012016390-A1 优先权日:2010-07-16 标 题 :Bioadhesive compounds and methods of synthesis and use 发明人:LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N 权利人:LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N; KNC NER ACQUISITION SUB INC 摘要:The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.
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合成参考文献
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