CAS: 1135-23-5; 3-(4-Hydroxy-3-Methoxyphenyl)Propanoic Acid

该化合物是有机化合物,其特点是碳酸酸性功能组和对丙酸脊的氢氧化甲基替代物,看起来像是白色晶状固体,由于存在极液基和碳酸基组,在水中可以溶解.该化合物因其作为有机合成和聚合化学的构件,特别是在生产聚酯和其他聚合物方面所发挥的作用而引人注目.其结构允许引入功能组,使其在各种化学反应中具有多种特性.此外,HMPA可以参与酯化和恐吓反应,有助于形成更复杂的分子.该化合物还具有生物化学应用的兴趣,在生物活性化合物合成中可以作为前体或中间体.安全数据表明,与许多有机酸一样,在处理时应当小心避免刺激或不利反应.

结构式图片

相似化合物

2305-13-7 56024-44-3 1135-15-5

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合成工艺路线路线简述

    📜3-(4-乙酰氧基-3-甲氧基苯基)丙酸置于水,Sodium Hydroxide体系中,化学反应 5.0H,以83%的收率获得3-(4-羟基-3-甲氧基苯基)丙酸
    参考文献:源自的生物可再生聚对苯二甲酸乙二酯模拟物 木质素 和 醋酸
    标题:源自的生物可再生聚对苯二甲酸乙二酯模拟物 木质素 和 醋酸
    摘要:木质素-基于 香兰素 和 醋酸酐 受到 珀金反应 进而 氢化 负担 乙酰二氢阿魏酸. 聚合 该单体的混合物产生聚(二氢阿魏酸),该聚(二氢阿魏酸)具有与聚对苯二甲酸乙二醇酯(pet)在功能上相似的热性能.
    Doi:10.1039/c0Gc00150C

    海关参考信息

    专利信息


    专利号:US-11746364-B2
    优先权日:2018-01-17
    标题 :Enzymatic synthesis of kavalactones and flavokavains
    发明人:PLUSKAL TOMÃ?S; Weng jing-ke
    权利人:WHITEHEAD INST BIOMEDICAL RES
    摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-6600001-B1
    优先权日:2002-01-11
    标 题:Alkylamino oxamides as low odor, non-fugitive catalysts for the production of polyurethanes
    发明人:GERKIN RICHARD M; ROBINSON KARENA KAYE; DERERIAN EDMOND J
    权利人:CROMPTON CORP
    摘要:A process for the synthesis of polyurethanes is disclosed wherein the process comprises reacting polyurethane-forming reactants in the presence of an effective amount of a catalyst comprising at least one alkylamino oxainide of the structure:wherein:R1 and R2 are independently selected alkyl groups or can be taken together to form a five or six-membered heterocyclic ring;R3 and R4 are independently selected from the group consisting of hydrogen and alkyl;n is 2 or 3;x is 0 or 1;Y is selected from the group consisting of O and NR9, wherein:R9 is selected from the group consisting of hydrogen and alkyl; andX is selected from the group consisting of OR10 and G, wherein:R10 is selected from the group consisting of hydrogen and alkyl; andG is

    专利号:US-2017266353-A1
    优先权日:2014-05-13
    标 题:Bioadhesive compounds and methods of synthesis and use
    发明人:MURPHY JOHN L; RADANO CHRISTOPHER P; DALSIN JEFFREY L; KOEPSEL JUSTIN T
    权利人:DSM IP ASSETS BV
    摘要:Synthesis methods for creating polymeric compounds comprising phenyl derivatives (PD), or PDp i.e., polymers modified with PD, with desired surface active effects are described. The polymer backbone of PDp has structural or performance features that can be tailored to control physical properties of PDp, allowing it to be useful for different applications i.e., tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

    专利号:US-2019271015-A1
    优先权日:2018-01-17
    标题 :Enzymatic synthesis of kavalactones and flavokavains

    专利号:US-2012016390-A1
    优先权日:2010-07-16
    标 题 :Bioadhesive compounds and methods of synthesis and use
    发明人:LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N
    权利人:LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N; KNC NER ACQUISITION SUB INC
    摘要:The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Beck Jj, Et Al. Fungicidal Activities Of Dihydroferulic Acid Alkyl Ester Analogues. J Nat Prod. 2007 May;70(5):779-82.
    [参考文献]: Deters M, Et Al. Different Curcuminoids Inhibit T-Lymphocyte Proliferation Independently Of Their Radical Scavenging Activities. Pharm Res. 2008 Aug;25(8):1822-7.
    [参考文献]: Paola Vitaglionea, Et Al. Gut Fermentation Induced By A Resistant Starch Rich Whole Grain Diet Explains Serum Concentration Of Dihydroferulic Acid And Hippuric Acid In A Model Of Zdf Rats. Journal Of Functional Foods. 53 (2019): 286-291.
    [参考文献]: Wong Cc, Et Al. Interaction Of Hydroxycinnamic Acids And Their Conjugates With Organic Anion Transporters And Atp-Binding Cassette Transporters. Mol Nutr Food Res. 2011 Jul;55(7):979-88.
    [参考文献]: Gema Pereira-Caro, Et Al. Chronic Administration Of A Microencapsulated Probiotic Enhances The Bioavailability Of Orange Juice Flavanones In Humans. Free Radic Biol Med. 2015 Jul:84:206-214.

    合成参考文献


    参考文献:10.1055/s-2005-871295
    摘要:Chou HC, Chen JJ, Duh CY, Huang TF, Chen IS. Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia. Planta Med. 2005 Nov;71(11):1078–81. doi: 10.1055/s-2005-871295.
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