CAS: 95416-25-4; (1R,4As,10Ar)-7-(2-Hydroxypropan-2-yl)-1,4A-Dimethyl-9-Oxo-1,2,3,4,4A,9,10,10A-Octahydrophenanthrene-1-Carboxylic Acid

该化合物是乙酸的一种二元素化合物,其特点是乙酸,其特征是其独特的氢氧基和氧功能组,分别位于第15和7位,这种结构配置具有独特的反应和潜在生物活动,使其成为有机合成和制药研究的宝贵中间体,其相近的三角系统可增强稳定性,同时允许选择性修改,便利药物研制和化学研究的应用.该化合物的明确界定的分子框架还支持将其用作分析化学的参考标准,其纯度和结构特性使其适合于调查生物活性二质的结构-活动关系.

结构式图片

物理性质

MSDS等安全信息

上下游产品

dehydroabietic acid acetic anhydride methyl 15-hydroxy-7-oxo-8,11,13-abietatrien-18-oate ((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-°Ctahydro-phenanthren-1-yl)-diphenyl-methanol methyl 15-hydroxy-7-oxo-8,11,13-abietatrien-18-oate

合成工艺路线路线简述

  • 120591-61-9 = 95416-25-4
    反应条件:1.1 Reagents: Potassium Hydroxide,(1R,4As,10Ar)-7-Acetyl-1,2,3,4,4A,9,10,10A-Octahydro-1,4A-Dimethyl-9-Oxo-1-Phena... Solvents: Diethylene Glycol,Water1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:The Conversion Of (+)-Dehydroabietic Acid Into Steroidal Hormones
    作者:Matsumoto,Takashi; Imai,Sachihiko; Sunaoka,Yasuhiro; Yoshinari,Takashi
    参考文献:Bulletin Of The Chemical Society Of Japan 日期:1988 卷标:61(3) 页码:723-7]

    60188-95-6 = 95416-25-4
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 8 H,Reflux
    标题:Aerobic Oxidation Of 8,11,13-Abietatrienes Catalyzed By N-Hydroxyphthalimide Combined With 2,2'-Azobis(4-Methoxy-2,4-Dimethylvaleronitrile) And Its Application To Synthesis Of Naturally Occurring Diterpenes
    作者:Matsushita,Yoh-Ichi; Sugamoto,Kazuhiro; Iwakiri,Yoshihisa; Yoshida,Satoru; Chaen,Takehito; Et Al
    参考文献:Tetrahedron Letters 日期:2010 卷标:51(30) 页码:3931-3934]

    60188-95-6 = 95416-25-4
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethylene Glycol,Water; Rt -> 120 °C; 3.5 H,120 °C
    标题:Catalytic,Tunable,One-Step Bismuth(Iii) Triflate Reaction With Alcohols: Dehydration Versus Dimerization
    作者:Kolsi,Laura E.; Yli-Kauhaluoma,Jari; Moreira,Vania M.
    参考文献:Acs Omega 日期:2018 卷标:3(8) 页码:8836-8842]

    = 95416-25-4 [标题:Reaction Conditions
    标题:New Route To 15-Hydroxydehydroabietic Acid Derivatives: Application To The First Synthesis Of Some Bioactive Abietane And Nor-Abietane Type Terpenoids
    作者:Alvarez-Manzaneda,E. J.; Chahboun,R.; Guardia,J. J.; Lachkar,M.; Dahdouh,A.; Et Al
    参考文献:Tetrahedron Letters 日期:2006 卷标:47(15) 页码:2577-2580
📜脱氢松香酸 反应生成 15-羟基-7-氧代去氢松香酸
参考文献:Matsumoto,Takashi;Imai,Sachihiko;Sunaoka,Yasuhiro;Yoshinari,Takashi,Bull. Chem. Soc. Jap.,61,(1988) N 3,723-727
标题:Matsumoto,Takashi;Imai,Sachihiko;Sunaoka,Yasuhiro;Yoshinari,Takashi,Bull. Chem. Soc. Jap.,61,(1988) N 3,723-727

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主要参考文献

参考标题:Aerobic Oxidation Of 8,11,13-Abietatrienes Catalyzed By N-Hydroxyphthalimide Combined With 2,2′-Azobis(4-Methoxy-2,4-Dimethylvaleronitrile) And Its Application To Synthesis Of Naturally Occurring Diterpenes
作者:Yoh-Ichi Matsushita,Kazuhiro Sugamoto,Yoshihisa Iwakiri,Satoru Yoshida,Takehito Chaen,Takanao Matsui |发布日期:2010.7
摘要:13-Abietatriene-18-Oate (1B) And 7-Oxo-8,11,13-Abietatrienes 10 And 15 Were Converted Into 15-Hydroperoxy-7-Oxo-8,11,13-Abietatrienes 13 And 16 By Aerobic Oxidation Catalyzed By N-Hydroxyphthalimide (Nhpi) Combined With 2,2′-Azobis(4-Methoxy-2,4-Dimethylvaleronitrile) (V-70) At Room Temperature, And Several Abietane And Podocarpane Terpenes Were Synthesized From 13 And 16.

合成参考文献

参考DOI号:10.1016/j.tetlet.2010.05.090
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