CAS: 875-51-4; 4-Bromo-2-Nitroaniline

上下游产品

CAS号88-74-4 2-硝基苯胺 | CAS号881-50-5 4-溴-2-硝基乙酰苯胺 | CAS号75-09-2 二氯甲烷 | CAS号7529-22-8 N-甲基吗啉氧化物 | CAS号15788-16-6 1H-苯并咪唑-5-羧酸 | CAS号106-40-1 对溴苯胺 | CAS号20244-61-5 2,4,4,6-四溴-2,5-环己二烯酮 | CAS号103-88-8 4'-溴乙酰苯胺 | CAS号3460-18-2 2,5-二溴硝基苯 | CAS号35527-28-7 4-(2-nitropheny... | CAS号34033-41-5 4-溴-2-氯-6-硝基苯胺 | CAS号32046-62-1 5-溴-1H-苯并三氮唑 | CAS号57339-57-8 6-溴-8-氨基喹啉 | CAS号500889-65-6 3-氨基-7-溴-1,2,4-苯并三嗪 | CAS号51376-06-8 5-溴-2,1,3-苯并恶唑 | CAS号4887-88-1 5-溴-1H-苯并咪唑 | CAS号426268-09-9 苯并[c][1,2,5]恶二唑... | CAS号18470-23-0 2,3-二甲基-6-溴喹噁啉 | CAS号88-74-4 2-硝基苯胺 | CAS号95-54-5 邻苯二胺(OPD)

2-硝基苯胺置于n-溴代丁二酰亚胺(Nbs),溶剂黄146体系中,化学反应 0.15H,以94%的收率获得产物4-溴-2-硝基苯胺
参考文献:I类hdac抑制剂开发中环大小的变化
标题:I类hdac抑制剂开发中环大小的变化
摘要:摘要 涉及不同环结构的五种途径导致产生十四种噻吩基苯甲酰胺 (7-20),它们显示出 I 类 Hdac 抑制剂的构效关系.所有合成的化合物都比其他同种型选择性地抑制 Hdac1 和 Hdac2,并且许多化合物比母体化合物更有效地抑制 Dld1 和 Hct116 细胞.化合物8和16通过激活细胞凋亡途径抑制 Hct116 细胞.
DOI:10.1080/14756366.2021.1941920

专利信息

专利号:US-8901304-B1
优先权日:2013-11-05
标题:Benzo[D]imidazole derivatives of piperidine and piperazine
发明人：ULLAH NISAR
权利人:UNIV KING FAHD PET & MINERALS; KING ABDULAZIZ CITY SCI & TECH
摘要:The benzo[d]imidazole derivatives of piperidine and piperazine are 5-piperazinyl and 5-piperadinyl-1H-benzo[d]imidazol-2(3H)-ones that exhibit D 2 and 5-HT 1A receptor binding affinities, making them suitable for use as the active ingredient of pharmaceuticals for the treatment of schizophrenia. The derivatives have the general formula: n nwhere X is carbon or nitrogen and R is a selected biaryl group, or a pharmaceutically acceptable salt thereof. The piperidinyl compounds are prepared by removal of the Boc group from tert-Butyl-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperidine-1-carboxylate. Subsequent reductive amination with a selected biarylaldehyde completes the synthesis of the 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones. The piperazinyl compounds are prepared by preparation of the intermediate tert-Butyl 4-(3,4-diaminophenyl)piperazine-1-carboxylate. Removal of the Boc group and subsequent reductive amination with a selected biarylaldehyde completes the synthesis of the 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones.

专利号:US-2004029774-A1
优先权日:2002-08-06
标 题:Composition and methods for the treatment of musculoskeletal disorders and collagen and elastin deficiencies
发明人：GAMAY ALY
摘要:Disclosed is a composition and method of enhanced nutrients delivery system for the treatment of musculoskeletal disorders and promotion of collagen and elastin synthesis in mammals by the oral administration of gel-like composition of hydrated Chondoritin, Glucosamine, MSM (Methyl-Sulfonyl-Methane), gelatin, hydrolyzed gelatin, collagen, and/or hydrolyzed collagen in combination with gelling agents. The increased bioavailability of the composition aids in the relief of joint pain and rebuilds cartilages, tendons, muscles, skin and connective tissues.

专利号:US-9742034-B2
优先权日:2012-12-26
标题 :Cyano-benzimidazole salts for electrochemical cells and method for synthesis thereof
发明人：CHERN YAW-TERNG; JENG JYH-LONG; CHEN SZU-YUAN; WEI AN-SHING; HWANG BING-JOE
权利人:UNIV NAT TAIWAN SCIENCE TECH
摘要:The present invention discloses a new metal cyano-substituted benzimidazolide salt having formula (I) and its preparation. This new cyano-substituted benzimidazole derivatives exhibited excellent thermal stability. The organic salt of the present invention were soluble in an alkyl carbonate solvent, such as propylene carbonate (PC), dimethyl carbonate (DMC) and ethylene carbonate (EC)/DMC cosolvent. The non-aqueous electrolyte prepared by mixing the organic metal salt of the present invention with the alkyl carbonate solvent shows high conductivity and excellent electrochemical stability. The non-aqueous electrolyte is suitable for use in primary or secondary rechargeable batteries.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-9745253-B2
优先权日:2015-03-13
标 题 :Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
发明人：BAIR KENNETH W; Barczak Nicholas; HAN BINGSONG; LANCIA JR DAVID R; LIU CUIXIAN; MARTIN MATTHEW W; NG PUI YEE; Rudnitskaya Aleksandra; THOMASON JENNIFER R; ZABLOCKI MARY MARGARET; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

专利号:US-8518952-B2
优先权日:2008-08-06
标题 :6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors
发明人：BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER
权利人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER; PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.