CAS: 86-34-0; 1-Methyl-3-Phenylpyrrolidine-2,5-Dione

该化合物是一种化学化合物,被归类为sucnimide衍生物,主要用于医疗领域,作为抗抽搐剂;众所周知,它能有效治疗癫痫,特别是在控制缺勤缉获方面;该化合物的分子配方反映了其结构,包括含有氮原子的五人环. 磷酰胺通常是白色的脱白晶状固体,在乙醇和乙醇等有机溶剂中溶解,但水溶解性有限;其行动机制涉及...

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号853955-69-8 2-(Dimethylphen... | CAS号930-88-1 N-甲基马来酰亚胺 | CAS号635-51-8 苯基丁二酸 | CAS号74-89-5 氨基甲烷 | CAS号6837-05-4 2(R)-Phenyl-1,4... | CAS号49601-28-7 5-hydroxyimino-... | CAS号140-29-4 苯乙腈 | CAS号54433-49-7 1-甲基-3-苯基-1H-吡咯... | CAS号54433-49-7 1-甲基-3-苯基-1H-吡咯...

合成工艺路线路线简述

  • 合成目标产物 Phensuximide 主要起始原料 N-Methylmaleimide And Phenylboronic Acid
  • 398130-26-2 = 86-34-0
    反应条件:1.1 Reagents: Acetic Acid,Zinc Solvents: Acetic Acid
    标题:Synthesis Of Methylthiomaleimides For The Preparation Of Pyridazines And Related Compounds
    作者:Tominaga,Yoshinori; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:2002 卷标:39(3) 页码:571-591]

    398130-26-2 = 86-34-0
    反应条件:1.1 Reagents: Zinc Solvents: Acetic Acid
    标题:Synthesis Of 3-Methylthio-4-Aryl-3-Pyrroline-2,5-Diones And 3-Arylpyrrolidine-2,5-Diones By Reaction Of Nitroketene Dithioacetal With Arylacetonitriles
    作者:Shigemitsu,Yasuhiro; Et Al
    参考文献:Heterocycles 日期:2001 卷标:55(12) 页码:2257-2260]

    635-51-8 = 86-34-0 [标题:Reaction Conditions
    标题:Anticonvulsants. I. N-R-α-R1-α-Phenylsuccinimides
    作者:Miller,C. A.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:1951 卷标:73 页码:4895-8]

    930-88-1 + 98-80-6 = 86-34-0
    反应条件:1.1 Catalysts: 4,4′-Bipyridine,Palladium Diacetate Solvents: Acetic Acid,Tetrahydrofuran,Water; 24 H,80 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
    标题:A Unified Strategy For The Synthesis Of Difluoromethyl- And Vinylfluoride-Containing Scaffolds
    作者:Duchemin,Nicolas; Et Al
    参考文献:Organic Letters 日期:2019 卷标:21(20) 页码:8205-8210]

    930-88-1 + 65-85-0 = 86-34-0
    反应条件:1.1 Catalysts: [(1,2,3,4,5,6-η)-1-Methyl-4-(1-Methylethyl)Benzene](2,4,6-Trimethylbenzoato-Ko)(... Solvents: 1,2-Dichloroethane; 24 H,110 °C
    标题:Mild Decarboxylative C-H Alkylation: Computational Insights For Solvent-Robust Ruthenium(Ii) Domino Manifold
    作者:Kumar,N. Y. Phani; Et Al
    参考文献:Chemistry - A European Journal 日期:2017 卷标:23(69) 页码:17449-17453]

    22903-00-0 = 86-34-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone2.1 Reagents: Zinc Solvents: Acetic Acid
    标题:Synthesis Of 3-Methylthio-4-Aryl-3-Pyrroline-2,5-Diones And 3-Arylpyrrolidine-2,5-Diones By Reaction Of Nitroketene Dithioacetal With Arylacetonitriles
    作者:Shigemitsu,Yasuhiro; Et Al
    参考文献:Heterocycles 日期:2001 卷标:55(12) 页码:2257-2260]

    = 86-34-0
    反应条件:1.1 Reagents: Sodium Nitrite,Tetrafluoroboric Acid Solvents: Water; 20 Min,0 °C; 3 H,0 °C2.1 Reagents: Sodium Acetate Catalysts: Titanium Chloride (Ticl3) Solvents: Acetone; 0 °C2.2 1 H,0 °C; 0 °C -> 25 °C; 6 H,25 °C
    标题:Selective And Tunable Synthesis Of 3-Arylsuccinimides And 3-Arylmaleimides From Arenediazonium Tetrafluoroborates And Maleimides
    作者:Yang,Zhen-Hua; Et Al
    参考文献:Rsc Advances 日期:2016 卷标:6(28) 页码:23438-23447]

    49601-28-7 = 86-34-0
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water2.1 Reagents: Potassium Carbonate Solvents: Acetone3.1 Reagents: Zinc Solvents: Acetic Acid
    标题:Synthesis Of 3-Methylthio-4-Aryl-3-Pyrroline-2,5-Diones And 3-Arylpyrrolidine-2,5-Diones By Reaction Of Nitroketene Dithioacetal With Arylacetonitriles
    作者:Shigemitsu,Yasuhiro; Et Al
    参考文献:Heterocycles 日期:2001 卷标:55(12) 页码:2257-2260]

    13623-94-4 = 86-34-0
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethyl Sulfoxide1.2 Reagents: Methanol Solvents: Methanol2.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water3.1 Reagents: Potassium Carbonate Solvents: Acetone4.1 Reagents: Zinc Solvents: Acetic Acid
    标题:Synthesis Of 3-Methylthio-4-Aryl-3-Pyrroline-2,5-Diones And 3-Arylpyrrolidine-2,5-Diones By Reaction Of Nitroketene Dithioacetal With Arylacetonitriles
    作者:Shigemitsu,Yasuhiro; Et Al
    参考文献:Heterocycles 日期:2001 卷标:55(12) 页码:2257-2260]

    3464-18-4 = 86-34-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; Overnight,Reflux
    标题:Light-Induced Divergent Cyanation Of Alkynes Enabled By Phosphorus Radicals
    作者:Zhang,Yanyan; Et Al
    参考文献:Angewandte Chemie 日期:2022 卷标:61(50)]

    635-51-8 = 86-34-0
    反应条件:1.1 Catalysts: Niobium Oxide (Nb2O3) Solvents: Hexane,Water; Rt -> Reflux; 30 H,Reflux
    标题:Versatile And Sustainable Synthesis Of Cyclic Imides From Dicarboxylic Acids And Amines By Nb2O5 As A Base-Tolerant Heterogeneous Lewis Acid Catalyst
    作者:Ali,Ayub Md.; Et Al
    参考文献:Chemistry - A European Journal 日期:2014 卷标:20(44) 页码:14256-14260]

    930-88-1 + 98-80-6 = 86-34-0
    反应条件:1.1 Reagents: Oxygen Catalysts: 2,2′-Bipyridine,Palladium Diacetate Solvents: Acetic Acid,Tetrahydrofuran,Water; 24 H,80 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
    标题:Pd(Ii)/bipyridine Catalyzed Conjugate Addition Of Arylboronic Acids To α,β-Unsaturated Amides
    作者:Ji,Jiamin; Et Al
    参考文献:Tetrahedron Letters 日期:2016 卷标:57(25) 页码:2723-2726]

    930-88-1 + 98-80-6 = 86-34-0
    反应条件:1.1 Catalysts: 4,4′-Bipyridine,Palladium Diacetate Solvents: Acetic Acid,Tetrahydrofuran,Water; 24 H,80 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
    标题:Sequential C-Selective Difluoromethylation/pd-Catalyzed Decarboxylative Protonation: An Efficient Access To Tertiary Difluoromethylated Scaffolds
    作者:Duchemin,Nicolas; Et Al
    参考文献:Chemrxiv 日期:2019 卷标:1 页码:1-8]

    930-88-1 + 14874-70-5 + 2684-02-8 = 86-34-0
    反应条件:1.1 Reagents: Sodium Acetate Catalysts: Titanium Chloride (Ticl3) Solvents: Acetone; 0 °C1.2 1 H,0 °C; 0 °C -> 25 °C; 6 H,25 °C
    标题:Selective And Tunable Synthesis Of 3-Arylsuccinimides And 3-Arylmaleimides From Arenediazonium Tetrafluoroborates And Maleimides
    作者:Yang,Zhen-Hua; Et Al
    参考文献:Rsc Advances 日期:2016 卷标:6(28) 页码:23438-23447]

    930-88-1 + 853955-69-8 = 86-34-0
    反应条件:1.1 Catalysts: Bis[(1,2,5,6-η)-1,5-Cyclooctadiene]Di-μ-Hydroxydirhodium Solvents: Tetrahydrofuran; 4 H,35 °C
    标题:Organo[2-(Hydroxymethyl)Phenyl]Dimethylsilanes As Mild And Reproducible Agents For Rhodium-Catalyzed 1,4-Addition Reactions
    作者:Nakao,Yoshiaki; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2007 卷标:129(29) 页码:9137-9143]

    6837-05-4 = 86-34-0
    反应条件:1.1 Reagents: Sodium Hydride Catalysts: Acetonitrile,(Oc-6-22)-Dihydrotetrakis(Triphenylphosphine)Ruthenium,1H-Imidazolium,1,3-Bis(1-Methylethyl)-,Bromide (1:1) Solvents: Toluene; 20 Min,Reflux1.2 24 H,Reflux
    标题:Synthesis Of Cyclic Imides From Simple Diols
    作者:Zhang,Jian; Et Al
    参考文献:Angewandte Chemie 日期:2010 卷标:49(36) 页码:6391-6395]

    1131-15-3 = 86-34-0
    反应条件:1.1 Solvents: 1,2-Dichloroethane,Water; 23 °C; 4 H,80 °C; 80 °C -> 23 °C1.2 Reagents: Acetyl Chloride; Rt; 1 H,80 °C; 80 °C -> 23 °C
    标题:Aminoketyl Radicals In Organic Synthesis: Stereoselective Cyclization Of Five- And Six-Membered Cyclic Imides To 2-Azabicycles Using Smi2-H2O
    作者:Shi,Shicheng; Et Al
    参考文献:Organic Letters 日期:2015 卷标:17(20) 页码:5144-5147]

    13706-68-8 = 86-34-0
    反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Acetic Acid; 1 H,Reflux; Cooled1.2 Reagents: Sodium Bicarbonate Solvents: Water2.1 Reagents: Potassium Carbonate Solvents: Acetone; Overnight,Reflux
    标题:Light-Induced Divergent Cyanation Of Alkynes Enabled By Phosphorus Radicals
    作者:Zhang,Yanyan; Et Al
    参考文献:Angewandte Chemie 日期:2022 卷标:61(50)]

    22903-00-0 = 86-34-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone2.1 Reagents: Acetic Acid,Zinc Solvents: Acetic Acid
    标题:Synthesis Of Methylthiomaleimides For The Preparation Of Pyridazines And Related Compounds
    作者:Tominaga,Yoshinori; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:2002 卷标:39(3) 页码:571-591]

    49601-28-7 = 86-34-0
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol2.1 Reagents: Potassium Carbonate Solvents: Acetone3.1 Reagents: Acetic Acid,Zinc Solvents: Acetic Acid
    标题:Synthesis Of Methylthiomaleimides For The Preparation Of Pyridazines And Related Compounds
    作者:Tominaga,Yoshinori; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:2002 卷标:39(3) 页码:571-591]

    7677-24-9 = 86-34-0
    反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Triphenylphosphine,Iridium(1+),[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-Kn1,Kn1′]Bis[3,5-Diflu... Solvents: Acetonitrile; 6 H,35 °C1.2 Solvents: Water2.1 Catalysts: Sulfuric Acid Solvents: Acetic Acid; 1 H,Reflux; Cooled2.2 Reagents: Sodium Bicarbonate Solvents: Water3.1 Reagents: Potassium Carbonate Solvents: Acetone; Overnight,Reflux
    标题:Light-Induced Divergent Cyanation Of Alkynes Enabled By Phosphorus Radicals
    作者:Zhang,Yanyan; Et Al
    参考文献:Angewandte Chemie 日期:2022 卷标:61(50)]

    13623-94-4 = 86-34-0
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethyl Sulfoxide1.2 Solvents: Methanol2.1 Reagents: Hydrochloric Acid Solvents: Methanol3.1 Reagents: Potassium Carbonate Solvents: Acetone4.1 Reagents: Acetic Acid,Zinc Solvents: Acetic Acid
    标题:Synthesis Of Methylthiomaleimides For The Preparation Of Pyridazines And Related Compounds
    作者:Tominaga,Yoshinori; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:2002 卷标:39(3) 页码:571-591]

    930-88-1 + 98-80-6 = 86-34-0 + 54433-49-7
    反应条件:1.1 Reagents: Oxygen,Potassium Fluoride Catalysts: 2,2′-Bipyridine,Palladium Diacetate Solvents: Acetic Acid,Tetrahydrofuran,Water; 48 H,40 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
    标题:Pd(Ii)/bipyridine Catalyzed Conjugate Addition Of Arylboronic Acids To α,β-Unsaturated Amides
    作者:Ji,Jiamin; Et Al
    参考文献:Tetrahedron Letters 日期:2016 卷标:57(25) 页码:2723-2726
📜1-Methyl-3-Methylsulfanyl-4-Phenylpyrrole-2,5-Dione置于溶剂黄146,锌体系中,化学反应 1.0H,以93%的收率获得产物苯琥胺
参考文献:Synthesis Of 3-Methylthio-4-Aryl-3-Pyrroline-2,5-Diones And 3-Arylpyrrolidine-2,5-Diones By Reaction Of Nitroketene Dithioacetal With Arylacetonitriles
标题:Synthesis Of 3-Methylthio-4-Aryl-3-Pyrroline-2,5-Diones And 3-Arylpyrrolidine-2,5-Diones By Reaction Of Nitroketene Dithioacetal With Arylacetonitriles
摘要:The Reaction Of Nitroketene Dithioacetal (1A),I.E.,2,2-Bis(Methylthio)-1-Nitroethylene,With Arylacetonitriles (2A-I) In The Presence Of The Base Like Sodium Hydroxide Gave 4-Nitrobut-2-Enenitriles (3A-I) Which Were Converted Into 5-Hydroxyimino-4-Methylthio-3-Phenyl-3-Pyrrolin-2-Ones (4A-I) Under Refluxing In Methanol. Title Compounds (5A-I) Were Readily Obtained By The Treatment Of 4A-I With Hydrochloric Acid And Were Finally Led To N-Methylated Products (6A-I) With Methyl Iodide. The Reduction Of Maleimides (4-6) With Zinc Dust In Acetic Acid Afforded The Corresponding 3-Arylpyrrolidine-2,5-Diones (7A-I) That Can Be Converted To Pharmacologycally Active Compounds Like Mesembrines.
DOI:10.3987/com-01-9336

海关参考信息

专利信息


专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:WO-2012002913-A1
优先权日:2010-07-02
标 题:Process of forming a cyclic imide
发明人：HONG SOON HYEOK; ZHANG JIAN; MUTHAIAH SENTHILKUMAR; GHOSH SUBHASH CHANDRA
权利人:UNIV NANYANG TECH; HONG SOON HYEOK; ZHANG JIAN; MUTHAIAH SENTHILKUMAR; GHOSH SUBHASH CHANDRA
摘要:A process is provided for the synthesis of a cyclic imide. A primary amine and a diol compound are contacted in the presence of a Ruthenium (II) complex. The Ruthenium (II) catalyst includes at least one of an alicyclic ligand, an aromatic ligand, an arylalicyclic ligand, an arylaliphatic ligand and a phosphine ligand.

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles

专利号:US-8945508-B2
优先权日:2009-10-13
标 题 :Dendrimer compositions and methods of synthesis
发明人：BAKER JR JAMES R; HUANG BAOHUA
权利人:BAKER JR JAMES R; HUANG BAOHUA; UNIV MICHIGAN
摘要:The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).

专利号:WO-2005075459-A1
优先权日:2004-02-03
标题:Synthesis of cyanoimino-benzoimidazoles

专利号:US-2013030282-A1
优先权日:2011-07-18
标题:Synthesis and characterization of near ir fluorescent magnetic and non-magnetic albumin nanoparticles for biomedical applications
发明人：MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL
权利人:UNIV BAR ILAN; MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL
摘要:The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Ma C, Xiong J, Su H, Li H. The underlying molecular mechanism and drugs for treatment in adrenal cortical carcinoma. Int J Med Sci. 2021 Jun 16;18(13):3026-3038. doi: 10.7150/ijms.60261.
2: Wang S, Meng X, Wang Y, Liu Y, Xia J. HPO-Shuffle: an associated gene prioritization strategy and its application in drug repurposing for the treatment of canine epilepsy. Biosci Rep. 2019 Sep 6;39(9):BSR20191247. doi: 10.1042/BSR20191247.
3: Ali MA, Siddiki SM, Kon K, Hasegawa J, Shimizu K. Versatile and sustainable synthesis of cyclic imides from dicarboxylic acids and amines by Nb2O5 as a base-tolerant heterogeneous Lewis acid catalyst. Chemistry. 2014 Oct 27;20(44):14256-60. doi: 10.1002/chem.201404538. Epub 2014 Sep 15. 18(2):183-6. Chinese. 74(1):77-88. doi: 10.1016/0300-483x(92)90045-g. 10(3):203-9. doi: 10.1002/jat.2550100311. 10(2):143-52. doi: 10.1002/jat.2550100214. 11(3):337-42. doi: 10.1097/00007691-198905000-00018. 240(1):216-22. 6(5):349-56. doi: 10.1002/jat.2550060509. 4(3):601-16. 8(3):125-43. doi: 10.3109/01480548508999165.

合成参考文献


摘要:Arzneimittel-Forschung. Drug Research., 23(377), 1973 []
参考文献:10.1212/wnl.4.2.137
摘要:SMITH B, FORSTER FM. Mysoline and milontin, two new medicines for epilepsy. Neurology. 1954 Feb;4(2):137–42. doi: 10.1212/wnl.4.2.137.
摘要:LEMERE F. Milontin in treatment of petit mal epilepsy. Northwest Med. 1954 May;53(5):482.
参考文献:10.1016/s0022-3565(25)11274-3
摘要:Glazko AJ, Dill WA, Wolf LM, Miller CA. THE DETERMINATION AND PHYSIOLOGICAL DISPOSITION OF MILONTIN (N-METHYL-α-PHENYLSUCCINIMIDE). The Journal of Pharmacology and Experimental Therapeutics. 1954 Aug;111(4):413–24. doi: 10.1016/s0022-3565(25)11274-3.
参考文献:10.2165/00003088-199223020-00005
摘要:Murray M. P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease. Clin Pharmacokinet. 1992 Aug;23(2):132–46. doi: 10.2165/00003088-199223020-00005.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知