CAS: 790667-99-1; (2S,4S)-Tert-Butyl 4-Hydroxy-2-Methylpiperidine-1-Carboxylate

相似化合物

790668-06-3 790667-44-6 152491-42-4

上下游产品

1-N-Boc-2(S)-甲基-哌啶-4-酮 Tert-Butyl (2S)-2-Methyl-4-Oxopiperidine-1-Carboxylate 790667-49-1
1-叔丁氧羰基-2-甲基-哌啶酮 Tert-Butyl 2-Methyl-4-Oxopiperidine-1-Carboxylate 190906-92-4

1-N-Boc-2(S)-甲基-哌啶-4-酮置于potassium Dihydrogenphosphate,葡萄糖,Nadp+ Monosodium Salt,碳酸氢钠,Sodium Hydroxide体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应 16.5H,以81%的收率获得产物2-甲基-2-丙基(2S,4S)-4-羟基-2-甲基-1-哌啶羧酸酯
参考文献: Combination Therapy[fr] Polythérapie
标题: Combination Therapy[fr] Polythérapie
摘要:本发明提供了一种治疗tau介导的认知或神经退行性疾病的方法,包括向需要此类治疗的患者施用有效量的抗tau抗体和oga抑制剂.

专利信息

专利号:US-5322852-A
优先权日:1992-02-17
标 题:Aminooxy piperidines as ornithine decarboxylase inhibitors
发明人：FREI JOERG; STANEK JAROSLAV
权利人:CIBA GEIGY CORP
摘要:The invention relates to compounds of formula I (I) wherein either R1 is a radical of formula Ia, -(CH2)n-O-NH2(Ia) in which n is 0 or 1, is hydrogen and R2 is a radical of formula Ib, -(CH2)p-O-NH2(Ib) in which p is 1 or 2, and wherein R is C1-C2alkyl which is attached to one carbon atom of the central piperidine ring system, but not to the same carbon atom as R1 of formula Ia or as R2 of formula Ib; and m is 1 or 2, and salts thereof. The invention further relates to the preparation of these compounds, to intermediates obtained during their synthesis, to pharmaceutical compositions which contain them, and to the use of said compounds for the therapeutic treatment of the human or animal body and for the preparation of pharmaceutical compositions. The compounds of formula I are inhibitors of ornithin decarboxylase.