CAS: 78906-15-7; Tert-Butyldimethyl(Oxiran-2-Ylmethoxy)Silane

该化合物是专门有机硅氧化物化合物,其特点是三丁基甲基硅(TBDMS)乙酰保护性氢氧化物组,其主要优点包括:由于TBDMS的细胞性提供消毒屏蔽,基本和核核循环条件下的稳定性得到加强.过氧化环为环的开关反应提供了再活动,使其在合成有机化学中有助于构建复杂的分子框架.硅醚组允许在温酸条件下有选择地去保护,使受控的功能化成为可能.这种化合物在多步合成中特别宝贵,因为需要正方保护组战略.它与一系列试剂和中间体的兼容性使它成为制药和材料科学应用的多用途建筑块.

结构式图片

相似化合物

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物理性质

MSDS等安全信息

上下游产品

CAS号196080-29-2 (4S)-4,5-bis[[t...

合成工艺路线路线简述

  • 556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Imidazole Solvents: Tetrahydrofuran; Overnight,Rt
    标题:Intramolecular Vinyl Quinone Diels-Alder Reactions: Asymmetric Entry To The Cordiachrome Core And Synthesis Of (-)-Isoglaziovianol
    作者:Loebermann,Florian; Weisheit,Lara; Trauner,Dirk
    参考文献:Organic Letters 日期:2013 卷标:15(17) 页码:4324-4326]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane
    标题:Studies Toward The Total Synthesis Of C14-Oxygenated Dolastane Natural Products
    作者:Leung,Lai To
    参考文献:2008]

    18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide1.2 Reagents: Sodium Bicarbonate,M-Chloroperbenzoic Acid Solvents: Dichloromethane
    标题:Reaction Of Dianions Derived From β-Keto Esters With Epoxides: Utility In The Preparation Of Synthetically Useful Tetrahydrofurans
    作者:Lygo,Barry; O'Connor,Norval; Wilson,Peter R.
    参考文献:Tetrahedron 日期:1988 卷标:44(22) 页码:6881-8]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Imidazole Solvents: Dichloromethane; 1.5 H,0 °C
    标题:Substrate Chirality And Specificity Of Diacylglycerol Kinases And The Multisubstrate Lipid Kinase
    作者:Epand,Richard M.; Shulga,Yulia V.; Timmons,Heath C.; Perri,Alexandra L.; Belani,Jitendra D.; Et Al
    参考文献:Biochemistry 日期:2007 卷标:46(49) 页码:14225-14231]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Imidazole Solvents: Dichloromethane; 10 Min,Rt; 17 H,Rt
    标题:Synthesis And Evaluation Of Novel Tlr2 Agonists As Potential Adjuvants For Cancer Vaccines
    作者:Lu,Benjamin L.; Williams,Geoffrey M.; Verdon,Daniel J.; Dunbar,P. Rod; Brimble,Margaret A.
    参考文献:Journal Of Medicinal Chemistry 日期:2020 卷标:63(5) 页码:2282-2291]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Imidazole Solvents: Tetrahydrofuran; Overnight,Rt
    标题:Cobalt-Catalyzed Carbonylation Of Epoxides To β-Lactones Promoted By Gallium Porphyrin
    作者:Li,Huimin; Tang,Yitian; Li,Zhijian; Li,Yonggang; Chen,Baoshu; Et Al
    参考文献:Molecular Catalysis 日期:2022 卷标:533]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Solvents: Tetrahydrofuran; 0 °C; 0 °C -> Rt; 24 H,Rt
    标题:Nhc-Catalyzed Ring Expansion Of Oxacycloalkane-2-Carboxaldehydes: A Versatile Synthesis Of Lactones
    作者:Wang,Li; Thai,Karen; Gravel,Michel
    参考文献:Organic Letters 日期:2009 卷标:11(4) 页码:891-893]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Imidazole Solvents: Dimethylformamide; 30 Min,0 °C; 0 °C -> Rt; 2 H,Rt1.2 Reagents: Sodium Chloride Solvents: Water; 20 Min,Rt
    标题:A Versatile Route To Polythiophenes With Functional Pendant Groups Using Alkyne Chemistry
    作者:Huang,Xiao; Yang,Li; Emanuelsson,Rikard; Bergquist,Jonas; Stroemme,Maria; Et Al
    参考文献:Beilstein Journal Of Organic Chemistry 日期:2016 卷标:12 页码:2682-2688]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Imidazole
    标题:A Study Toward A Total Synthesis Of Fostriecin
    作者:Kiyotsuka,Yohei; Igarashi,Junji; Kobayashi,Yuichi
    参考文献:Tetrahedron Letters 日期:2002 卷标:43(15) 页码:2725-2729]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran
    标题:Application Of Chromium Carbene Annulations And Cyclisations To Natural Product Synthesis
    作者:Ricketts,Dean C.
    参考文献:1993]

    556-52-5 + 18162-48-6 = 78906-15-7
    反应条件:1.1 Reagents: Imidazole Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C1.2 Solvents: Dichloromethane; 1 H,0 °C
    标题:Oxidative Cyclization Of Tertiary Pentenol Derivatives Forming 2,5,5-Trisubstituted Thf Rings And The Total Synthesis Of Cyclocapitelline
    作者:Phillips,Geoffrey A.; Palmer,Cory; Stevens,Andrew C.; Piotrowski,Mathew L.; Dekruyf,Daryl S. R.; Et Al
    参考文献:Tetrahedron Letters 日期:2015 卷标:56(44) 页码:6052-6055

海关参考信息

专利信息


专利号:US-2013196019-A1
优先权日:2010-03-18
标 题:Silicon-containing block co-polymers, methods for synthesis and use
发明人：WILLSON C GRANT; BATES CHRISTOPHER M; STRAHAN JEFFREY; ELLISON CHRISTOPHER JOHN; MUELLER BRENNEN
权利人:WILLSON C GRANT; BATES CHRISTOPHER M; STRAHAN JEFFREY; ELLISON CHRISTOPHER JOHN; MUELLER BRENNEN; NAT UNIVERSITY OF SINAPORE
摘要:The present invention describes the synthesis of silicon-containing monomers and copolymers. The synthesis of a monomer, trimethyl-(2-methylenebut-3-enyl)silane (TMSI) and subsequent synthesis of diblock copolymer with styrene, forming polystyrene-block-polytrimethylsilyl isoprene, and synthesis of diblock copolymer Polystyrene-block-polymethacryloxymethyltrimethylsilane or PS-b-P(MTMSMA). These silicon containing diblock copolymers have a variety of uses. One preferred application is as novel imprint template material with sub-100 nm features for lithography.

专利号:US-8410305-B2
优先权日:2007-11-12
标题 :Intermediates and methods for the preparation of epothilones
发明人：CHEN YUE; LI YONG
权利人:CHEN YUE; LI YONG; KOSAN BIOSCIENCES INC
摘要:Highly efficient methods are provided for preparing key intermediates in the synthesis of epothilones and use new alane reagents which are broadly applicable and can provide selected components having a variety of substituents groups.

专利号:US-7220870-B2
优先权日:1995-03-14
标 题:Hydrolytic kinetic resolution of cyclic substrates
发明人：JACOBSEN ERIC N; TOKUNAGA MAKOTO; LARROW JAY F
权利人:HARVARD COLLEGE
摘要:The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

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合成参考文献


摘要:Johnson, J. B., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 779.
摘要:Ibrahim, H., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 183.
摘要:Ibrahim, H., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 180.
摘要:Ibrahim, H., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 167.
摘要:Ibrahim, H., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 178.
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