CAS: 771-50-6; 1H-Indole-3-Carboxylic Acid

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CAS号120-72-9 吲哚 | CAS号124-38-9 二氧化碳 | CAS号5457-28-3 3-氰基吲哚 | CAS号83451-61-0 1-acetylindole-... | CAS号14618-45-2 3-(三氟乙酰基)吲哚 | CAS号942-24-5 3-吲哚甲酸甲酯 | CAS号487-89-8 3-吲哚甲醛 | CAS号298-14-6 碳酸氢钾 | CAS号407-25-0 三氟乙酸酐(TFAH) | CAS号2592-05-4 1H-吲哚-3-甲醛肟 | CAS号32387-21-6 1-甲基-3-吲哚酸 | CAS号942-24-5 3-吲哚甲酸甲酯 | CAS号108438-43-3 N-甲基吲哚-3-甲酸甲酯 | CAS号39891-70-8 吲哚啉-3-羧酸 | CAS号487-89-8 3-吲哚甲醛 | CAS号214759-95-2 N-甲氧基-n-甲基-1H-吲... | CAS号603-76-9 1-甲基吲哚 | CAS号27393-79-9 1H-indol-3-yl(p... | CAS号118-92-3 邻氨基苯甲酸 | CAS号482-89-3 靛蓝

吲哚-3-甲醇置于2,2,6,6-四甲基哌啶氧化物,水,Sodium Bromide,Sodium Hydroxide,Sodium Hypochlorite体系中,用 1,2-二氯乙烷,丙酮 作为反应溶剂,化学反应生成 3-吲哚甲酸
参考文献:自动机器学习辅助 Tempo 催化伯醇氧化制备羧酸
标题:自动机器学习辅助 Tempo 催化伯醇氧化制备羧酸
摘要:尽管醇氧化被认为是成熟的反应,但选择生产条件或预测未见醇的反应产率仍然是主要挑战.在此,公开了一种用于将伯醇催化氧化为相应羧酸的自动机器学习 (Ml) 模型.使用高通量实验 (Hte) 反应生成了包含 3444 个数据的数据集,其中包含 282 种伯醇和 45 种条件.使用 Hte 数据和 105 个描述符,使用 Autogluon(开源自动机器学习框架)和 Knime(开源数据分析平台)执行多标签预测.对于 240 次反应的独立测试(20 种未见醇和 12 种条件的完整矩阵),Autogluon 和用于产量预测的多标签预测 (Agmp) 表现出色.r 2为0.767,Mae为4.9%.该模型还表明,新反应生成的描述符(y/n,反应反应性分类)是与产量预测最相关的描述符,为将 Hte 和 Ml 集成到有机合成中提供了新的视角.
DOI:10.1002/cjoc.202200555

专利信息

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:US-7563904-B2
优先权日:2002-08-07
标题:Synthesis intermediates useful for preparing zolmitriptan
发明人：DALMASES BARJOAN PERE; ARMENGOL ASPARO MONTSERRAT
权利人:INKE SA
摘要:In particular, this invention relates to the synthesis intermediates (IV), (V), (VI) and (VIII) useful for preparing zolmitriptanzohnitriptan or a pharmaceutically acceptable salt thereof, which includes a) Ppreparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and acidification to give hydrazine (III); b) In situ Reaction of the hydrazine hydrochloride (III) with α-keto-δ-valerolactone, to give the hydrazone (IV); c) Fischer indole synthesis of the hydrazone (IV), to give the pyranoindolone of formula (V); d) Ttransesterification of the pyranoindolone (V) to provide the compound (VI), in which R means a straight or branched C1-C4 alkyl; e) Conversion of the hydroxyl group of the compound (VI) into dimethylamino to give the indolecarboxylate (VII), in which R means a straight or branched C1-C4 alkyl; f) Ssaponification of the 2-carboalkoxy group of the compound (VII), to provide indolecarboxylic acid (VIII); g) Ddecarboxylation of the indolecarboxylic acid (VIII), to provide zolmitriptan and, eventually, to provide a pharmaceutically acceptable salt thereof.

专利号:WO-0112791-A1
优先权日:1999-08-12
标 题 :Dna shuffling of dioxygenase genes for production of industrial chemicals
发明人：SELIFONOV SERGEY A; NEWMAN LISA M
权利人:MAXYGEN INC; SELIFONOV SERGEY A; NEWMAN LISA M
摘要:This invention provides improved polypeptides, including dioxygenases, dehydrogenases, ligases and transferases that are useful for the biocatalytic synthesis of compounds such as α-hydroxycarboxylic acids, and aryl- and alkyl-hydroxy and carboxylic acid compounds. The polypeptides provided herein are improved in properties such as regioselectivity, enzymatic activity, stereospecificity, and the like. Methods for obtaining recombinant polynucleotides that encode these improved polypeptides are also provided, as are organisms that express the polypeptides and are thus useful for carrying out said biocatalytic syntheses. Also provided by the invention are methods for increasing said solvent resistance of organisms that are used in the synthetic methods.

专利号:US-11718864-B2
优先权日:2015-09-23
标 题 :Cells and method of cell culture
发明人：HILLER GREGORY WALTER; MITCHELL JEFFREY JOSEPH; MULUKUTLA BHANU CHANDRA; PEGMAN PAMELA MARY
权利人:PFIZER
摘要:The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.

专利号:US-2011105751-A1
优先权日:2008-03-31
标题:Conversion of tryptophan into beta-carboline derivatives
发明人：PIRC SAMO
权利人:LEAK PHARMACEUTICALS D D
摘要:The invention belongs in the field of organic chemistry and relates to a new shortened Pictet-Spengler type reaction for preparing isomerically pure β-carboline compounds useful for the synthesis of tadalafil.

专利号:WO-2010008727-A1
优先权日:2008-06-16
标 题:Asymmetric synthesis of allyl or allene oxindoles
发明人：KOZLOWSKI MARISA C; LINTON ELIZABETH CAROL
权利人:UNIV PENNSYLVANIA; KOZLOWSKI MARISA C; LINTON ELIZABETH CAROL
摘要:The invention concerns processes for the preparation of a compound of the formula I comprising contacting a compound of formula II with a catalyst, said catalyst comprises (i) at least one of Pd and Cu and (ii) one or more of diamine, diphosphine and aminophosphine ligands; wherein Z is -C(R 5 )(R 6 )-C(R 2 )=C(R 3 )(R 4 ) and Y is -C(R 3 )(R 4 )-C(R 2 )=C(R 5 )(R 6 ) or Z is -C(R 5 )(R 6 )-C≡C-R 3 ; Y is or -C(R 3 )=C=C(R 5 )(R 6 ); X is NH, NR 15 , O or S; a is O or an integer from 1 to 4 and R 1 -R 7 and R 15 are as defined in the specification.