CAS: 7175-34-0; (S)-2-Amino-4-(Methylamino)-4-Oxobutanoic Acid

该化合物是一种手性氨基酸衍生物,其基质为N-甲基替代品,其立体特性(S)配置使其对不对称合成,peptide修改和制药研究具有价值.该化合物的结构特征,包括一个碳oxyl组和二级氨基联结,增强了其作为生物活性分子或催化剂基石的效用.其纯度和定义的立体化学确保了在需要对应选择性的应用中,如药物开发或酶研究中,可再次推广.由于存在氨基和木箱的功能,可以进一步衍生,使其成为有机化学和药用化学的多种中间体.

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CAS号74-89-5 氨基甲烷

合成工艺路线路线简述

    📜N2-Benzyloxycarbonyl-N-Methyl-L-Asparagin-Benzylester置于palladium On Activated Charcoal 氢气体系中,用 甲醇,水 作为反应溶剂,化学反应生成 4-N-甲基天冬酰胺
    参考文献:Synthesis And Chromatographic Properties Of N-Alkyl-L-Asparagines
    标题:Synthesis And Chromatographic Properties Of N-Alkyl-L-Asparagines
    摘要:不可用.
    DOI:10.1139/v66-354

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    专利信息


    专利号:US-7452701-B2
    优先权日:1998-11-24
    标 题:Methods for the preparation of β-amino acids
    发明人:FREY PERRY A; RUZICKA FRANK J
    权利人:WISCONSIN ALUMNI RES FOUND
    摘要:Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare β-amino acids by methods that avoid the pitfalls of chemical synthesis. The present invention provides a method of producing enantiomerically pure β-amino acids from α-amino acids comprising catalyzing the conversion of an α-amino acid to a corresponding β-amino acid by utilizing a lysine 2,3-aminomutase as the catalyst.

    专利号:EP-2341140-B1
    优先权日:2005-12-01
    标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/bf02858913
    摘要:Faust M, Shear CB, Williams MW. Disorders of carbohydrate metabolism of apples (Watercore, internal breakdown, low temperature and carbon dioxide injuries). The Botanical Review. 1969 Apr;35(2):169–94. doi: 10.1007/bf02858913.
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