CAS: 68766-96-1; H-D-Pyr-Oet

相似化合物

66183-71-9 144978-12-1 144978-35-8

上下游产品

CAS号64-17-5 乙醇 | CAS号4042-36-8 d-焦谷氨酸 | CAS号6893-26-1 D-谷氨酸 | CAS号13107-55-6 D-glutamic acid... | CAS号16450-41-2 谷氨酸二乙酯 | CAS号64-17-5 乙醇 | CAS号4042-36-8 d-焦谷氨酸 | CAS号66673-40-3 (R)-(-)-5-羟基甲基-2-吡咯酮 | CAS号138541-53-4 (R)-5-(CHLOROME... | CAS号118918-76-6 (3S,7aR)-3-Phen... | CAS号118867-99-5 (3S,7aR)-3-Phen...

D-谷氨酸置于氯化亚砜体系中,25.0~150.0 °C,2.0 Kpa 条件下,反应 3.0H,反应生成 D-焦谷氨酸乙酯
参考文献:有效的全合成ai-77-B,一种来自短小芽孢杆菌ai-77的胃保护性物质
标题:有效的全合成ai-77-B,一种来自短小芽孢杆菌ai-77的胃保护性物质
摘要:以立体选择性和会聚的方式实现了ai-77-B(1)的首次全合成,这是一种来自短小芽孢杆菌ai-77的胃保护物质.在该合成中,通过将苄基阴离子17B 1,2-加成到boc-L-亮氨酸7B中,一步构建了二氢异香豆素部分2.(R)-谷氨酸以高度立体选择性的方式修饰了羟基氨基酸4.2 .hcl和4的缩合,分子内pinner反应,然后温和水解,得到ai-77-B(1).
DOI:10.1016/s0040-4020(01)82406-6

专利信息

专利号:US-8962863-B2
优先权日:2012-08-21
标 题:Process for the synthesis of substituted gamma lactams
发明人：DINH DANNY T; GARST MICHAEL E; OLD DAVID W; SYAGE ELIZABETH T; GORIN BORIS; LANTHIER CHRISTOPHER M; OUDENES JAN
权利人:ALLERGAN INC
摘要:The present invention provides synthetic processes for the preparation of a variety of well-defined substituted gamma lactams. The compounds that can be prepared by the process of the invention are useful for treating a variety of conditions. In some embodiments of the invention, the compounds are useful for treating ocular disorders, such as, for example, glaucoma, lowering of elevated intraocular pressure, and the like. In other embodiments, the compounds are useful for treating irritable bowel disease. In further embodiments, the compounds are useful in promoting hair growth. In still further embodiments, the compounds are useful in promoting wound healing, scar reduction, and the like.

专利号:BR-PI0710538-A2
优先权日:2006-04-20
标 题:process for the synthesis of a substantially pure stereoisomer, compounds, pharmaceutical composition comprising a compound, process for the synthesis of a compound and use thereof.

专利号:CN-115124448-A
优先权日:2022-07-20
标 题:A kind of method for one-pot synthesis of D-pyroglutamic acid derivatives

专利号:US-8835466-B2
优先权日:2006-04-20
标 题 :Synthesis and uses of pyroglutamic acid derivatives
发明人：Ã?LVAREZ BUILLA GÓMEZ JULIO; NOVELLA ROBISCO JOSÉ LUIS; MATÃ?A MARTÃ?N MA PAZ; SERNA PEREDA SONIA
权利人:Ã?LVAREZ BUILLA GÓMEZ JULIO; NOVELLA ROBISCO JOSÉ LUIS; MATÃ?A MARTÃ?N MA PAZ; SERNA PEREDA SONIA; PRODIMED SA
摘要:Novel pyroglutamic acid derivatives (I), wherein R 1 is —OH, —ORa, wherein Ra is alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, aralkyl or heterocyclyl; R 2 , R 3 and R 4 are independently H, a nitrogen protecting group which hydrolyzes under acidic conditions or phtalamide; X is a pharmaceutically acceptable anion; and Y is a N-containing group; either in the form of their isolated optically active stereoisomers or in the form of mixtures thereof, are useful compounds for enhancing an immuneresponse in a subject and/or for treating tumors, bacterial, fungal or viral infections, or autoimmune diseases.

专利号:US-2014058117-A1
优先权日:2012-08-21
标 题 :Process for the synthesis of substituted gamma lactams

专利号:CA-2882138-A1
优先权日:2012-08-21
标题:Process for the synthesis of substituted gamma lactams