CAS: 65101-87-3; Sodium (2S,4R,8S,E)-8-((2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-Hydroxy-2'-((2S,3S,5R,6R)-6-Hydroxy-6-(Hydroxymethyl)-3,5-Dimethyltetrahydro-2H-Pyran-2-yl)-9'-(((2S,5S,6R)-5-Methoxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-2,4',8,10'-Tetramethyl-1,1',6,6'
该化合物是一种化学化合物,属于被称为大型硫化物的抗生素类别,其特点是结构复杂,包括一个大型内酯环和有助于其生物活动的各种功能组,该化合物具有抗微生物特性,能够有效防治一系列细菌感染;钠盐形式在水溶溶液中增强了溶解性,便于其用于制药用途;Dianmycin的行动机制通常涉及抑制细菌中的蛋白合成,这是大型硫化物抗生素的一个共同特征;此外,它可能具有独特的药理动力特性,影响其吸收,分布,新陈代谢和生物系统中的排出;与许多抗生素一样,抗生素发展的潜力是其使用中的一个关键考虑因素.
- 英文名称Sodium (2S,4R,8S,E)-8-((2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-Hydroxy-2'-((2S,3S,5R,6R)-6-Hydroxy-6-(Hydroxymethyl)-3,5-Dimethyltetrahydro-2H-Pyran-2-yl)-9'-(((2S,5S,6R)-5-Methoxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-2,4',8,10'-Tetramethyl-1,1',6,6'
- 中文名称南昌霉素
- IUPAC名称sodium (2S,4R,8S,E)-8-((2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-hydroxy-2'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-9'-(((2S,5S,6R)-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,4',8,10'-tetramethyl-1,1',6,6'-tetraoxa[2,7'-bispiro[4.5]decan]-7-yl)-2,4,6-trimethyl-5-oxonon-6-enoate
- 其它别名Nanchangmycin A; Sodium; (E,2S,4R,8S)-8-[(2S,5R,7S,8R,9R)-7-Hydroxy-2-[(2R,4S,5S,7R,9S,10R)-2-[(2S,3S,5R,6R)-6-Hydroxy-6-(Hydroxymethyl)-3,5-Dimethyloxan-2-Yl]-9-[(2S,5S,6R)-5-Methoxy-6-Methyloxan-2-Yl]Oxy-4,10-Dimethyl-1,6-Dioxaspiro[4.5]Decan-7-Yl]-2,8-
- CAS编号65101-87-3
- MFCD编号:MFCD02874368
- 分子式:C47H77NaO14分子量:889.11
- 产品CID: 1633608
- 同类组份化合物CAS65101-87-3 (Sodium)35865-33-9 (free acid)
- 产品分类原料药 → 抗生素类药物 → 农用抗生素
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: XMAIRYYXDCNFKP-SEDNIUBGSA-M
- XMAIRYYXDCNFKP-NXQQWTHSNA-M
- 计算化学: 氢键受体数14.0氢键供体数3.0可旋转键数13.0
物理性质
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📌 第三方产品分析报告
主要参考文献
1: Guo X, Liu T, Deng Z, Cane DE. Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase. Biochemistry. 2012 Jan 31;51(4):879-87. doi: 10.1021/bi201768v. Epub 2012 Jan 17.
2: Yu Q, Du A, Liu T, Deng Z, He X. The biosynthesis of the polyether antibiotic nanchangmycin is controlled by two pathway-specific transcriptional activators. Arch Microbiol. 2012 Jun;194(6):415-26. doi: 10.1007/s00203-011-0768-8. Epub 2011 Nov 23. Epub 2013 Sep 29. doi: 10.1016/j.chembiol.2008.04.006.
5: Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane DE, Deng Z. Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis. Chem Biol. 2006 Sep;13(9):945-55. doi: 10.1021/ja1073432.
合成参考文献
参考文献:10.1021/acs.jmedchem.9b00775
摘要:Bernatchez JA, Tran LT, Li J, Luan Y, Siqueira-Neto JL, Li R. Drugs for the Treatment of Zika Virus Infection. J. Med. Chem. 2019 Sep 24;63(2):470–89. doi: 10.1021/acs.jmedchem.9b00775.
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