CAS: 607-66-9; 4-Methylquinolin-2(1H)-One

上下游产品

CAS号141-97-9 乙酰乙酸乙酯 | CAS号102-01-2 N-乙酰乙酰苯胺 | CAS号587-96-2 3-difluoroboran... | CAS号634-47-9 2-氯-4-甲基喹啉 | CAS号5234-26-4 N-(2-乙酰苯基)乙酰胺 | CAS号491-35-0 4-甲基喹啉 | CAS号4437-65-4 4-甲基喹啉-2-硫醇 | CAS号37778-22-6 3-溴-4-甲基喹啉-2(1H)-酮 | CAS号607-66-9 4-甲基喹诺酮 | CAS号141031-16-5 ethyl 4-methyl-... | CAS号4437-65-4 4-甲基喹啉-2-硫醇 | CAS号90914-95-7 6-氨基-4-甲基-喹啉-2-醇 | CAS号50488-44-3 4-溴-2-甲基喹啉 | CAS号491-35-0 4-甲基喹啉 | CAS号194659-06-8 2-(4-methylquin... | CAS号21298-80-6 (2-OXO-1,2-DIHY... | CAS号59-49-4 2-苯并噁唑酮

N-乙酰乙酰苯胺置于硫酸体系中,化学反应 0.5H,反应生成 2-羟基-4-甲基喹啉
参考文献:N-(苯并[d]噻唑-2-基)-2-羟基喹啉-4-羧酰胺作为抗癌剂的发现,合成和分子证实.
标题:N-(苯并[d]噻唑-2-基)-2-羟基喹啉-4-羧酰胺作为抗癌剂的发现,合成和分子证实.
摘要:努力开发了一系列苯并噻唑和喹啉稠合的生物活性化合物,这些生物活性化合物是通过使用一系列取代的乙酰乙酰苯胺通过四步合成路线而获得的.获得n-(苯并[D]噻唑-2-基)-2-羟基喹啉-4-羧酰胺(6A-1)的收率高达96%,而环保型p-Tsa用作催化剂.此外,使用一系列癌细胞系(从mcf-7(乳腺癌),Hct-116(结肠癌),Pc-3和lncap(前列腺)和sk-Hep-1(肝癌).由于抗氧物质(ros)对癌症的发展至关重要,因此在抗癌研究之前,也对本研究化合物的抗氧化性能进行了验证.为了确定所述化合物的细胞膜稳定性作用,确定了基于人红细胞(hrbc)的膜保护测定法.结果为化合物6A-1与本研究中使用的其他细胞系相比,它们能够在pc3细胞系(前列腺癌)上产生主要的结果值.由于已知人类生殖细胞碱性磷酸酶(hgc-Alp)在前列腺癌发展中的连通性,因此评估了活性最高的化合物对hgc-Alp的
DOI:10.1016/j.Bioorg.2019.103171

专利信息

专利号:CN-108503582-A
优先权日:2018-01-19
标 题:Microwave Assisted Synthesis of 2-(1H)-Quinolinones

专利号:US-7696246-B2
优先权日:1999-08-27
标题:Bicyclic androgen and progesterone receptor modulator compounds and methods
发明人：ZHI LIN; VAN OEVEREN CORNELIS ARJAN; MARTINBOROUGH ESTHER
权利人:LIGAND PHARM INC
摘要:The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.

专利号:CN-108503582-B
优先权日:2018-01-19
标 题:Microwave-assisted synthesis method of 2- (1H) -quinolinone compounds