CAS: 57834-33-0; Ethyl 4-(((Methyl(Phenyl)Amino)Methylene)Amino)Benzoate

上下游产品

benzoesaure-ethylester4-benzoesaure-ethylester N-methylaniline 4-nitro-benzoic acid orthoformic acid triethyl ester

对硝基苯甲酸置于硫酸体系中,80.0~140.0 °C,600.01 Kpa 条件下,反应 22.0H,反应生成 N-(乙氧基羰基苯基)-N'-甲基-N'-苯基脒
参考文献:N-(4-乙氧基羰基苯基)-N'-甲基-N'-苯基甲 脒的绿色制备工艺
标题:N-(4-乙氧基羰基苯基)-N'-甲基-N'-苯基甲 脒的绿色制备工艺
摘要:本发明公开了一种n‑(4‑乙氧基羰基苯基)‑n'‑甲基‑n'‑苯基甲脒的绿色制备工艺,它是先由对硝基苯甲酸经酯化反应和催化氢化反应制得对氨基苯甲酸乙酯,然后再由对氨基苯甲酸乙酯经两步缩合反应制得;所述酯化反应采用的乙醇为回收处理乙醇;所述回收处理乙醇是将缩合反应产生的乙醇收集后经回收处理得到.本发明的工艺将缩合反应产生的乙醇进行回收处理后用于酯化反应中,不仅降低了生产成本,而且减少了对环境的污染,是一种绿色制备工艺,尤其是经本发明回收处理后的乙醇与市售无水乙醇相比对酯化效果几乎没有影响.

专利信息

专利号:US-2024279231-A1
优先权日:2021-05-20
标题:Map4k4 inhibitors and methods of synthesis and use thereof
发明人：AWASTHI VIBHUDUTTA; EEDA VENKATESWARARAO
权利人:UNIV OKLAHOMA
摘要:The compound DMX-5804, IUPAC name 5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,4a,7,7a-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, is a potent and selective inhibitor of mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4). The present disclosure describes a scalable and practical synthesis process for making DMX-5804. The process (1) doesn't rely on transition metals, (2) has reduced duration of reactions, (3) is streamlined with significantly improved yields using low cost raw materials, (4) includes no microwave-assisted reactions, (5) does not require column purification, and (6) generally results in crystalized products having over a 95% purity in each step. The present disclosure also describes DMX-5804 analogs and derivatives for use in inhibiting MAP4K4, and scalable and practical processes for making such DMX-5804 analogs.

专利号:US-12319661-B2
优先权日:2018-12-10
标题 :Polycyclic compound
发明人：ZENG YUFENG
权利人:EUTEC NEW MATERIALS TECH SUZHOU CO LTD
摘要:Novel polycyclic compounds, synthesis methods and applications thereof are provided. The compound comprise a plurality of carbocyclic and/or heterocyclic structures having at least one group that emits visible light or fluorescence and at least one ultraviolet and/or visible (blue) light absorbing group covalently bonded to provide stability. The compounds can be used as a light conversion agent, dye, pigment, fluorescence agent, ultraviolet light or blue light absorber, and is applied to optical film, agricultural film, optical disk (disc), optical lens, goggles, skin care, makeup, lighting, coatings, adhesives, light stabilizers, or panels.