CAS: 5751-20-2; 2-(Methylthio)Pyrimidin-4(3H)-One

相似化合物

6328-58-1 81560-03-4 61044-94-8

上下游产品

CAS号141-90-2 2-硫脲嘧啶 | CAS号74-88-4 碘甲烷 | CAS号344361-86-0 4-(dimethylamin... | CAS号75-36-5 乙酰氯 | CAS号512-56-1 磷酸三甲酯 | CAS号109389-01-7 4-(N-benzylcarb... | CAS号5751-20-2 2-甲硫基-4-嘧啶酮 | CAS号111079-19-7 4-氯-5-碘-2-甲硫基嘧啶 | CAS号49844-90-8 4-氯-2-甲硫基嘧啶 | CAS号33643-94-6 4-羟基-2-苯基嘧啶 | CAS号148990-17-4 4-(4-甲氧苯基)-2-(甲巯基)嘧啶 | CAS号91719-61-8 2-甲硫基-4-苯甲氨基嘧啶 | CAS号66-22-8 尿嘧啶 | CAS号97229-11-3 4-氯-2-(甲基磺酰基)嘧啶 | CAS号189956-45-4 4-N[2(4-羟基嘧啶基)]氨基苯腈 | CAS号81560-03-4 5-溴-2-(甲硫基)嘧啶-4... | CAS号81560-09-0 2-(甲硫基)-4-甲氧基-5-溴嘧啶

碘甲烷置于sodium Hydroxide体系中,用 水,四氢呋喃 作为反应溶剂,化学反应 18.33H,以60%的收率获得产物2-甲硫基-4-嘧啶酮
参考文献:2-Anilino-4-(Heterocyclic) Amino-Pyrimidines
标题:2-Anilino-4-(Heterocyclic) Amino-Pyrimidines
摘要:本发明涉及2-芳基氨基-4-(杂环)氨基嘧啶抑制剂,这些抑制剂是蛋白激酶c-Alpha (Pkc-α)的抑制剂,因此能够抑制pkc-α.本发明的pkc-α抑制剂对于改善心肌细胞内钙循环非常重要,从而提高心肌的收缩和舒张性能,从而减缓心力衰竭的进展.本发明还涉及包含所述2-芳基氨基-4-(杂环)氨基嘧啶的组合物以及用于控制,减轻或以其他方式减缓心力衰竭进展的方法.

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CA-2394414-A1
优先权日:1999-12-16
标 题 :Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols carotenoids

专利号:WO-0063184-A1
优先权日:1999-04-16
标 题:Method for producing 2-(alkylthio)-4-chloropyrimidines
发明人：RODUIT JEAN-PAUL
权利人:LONZA AG; RODUIT JEAN PAUL
摘要:The invention relates to 2- (alkylthio) -4- chloropyrimidines of general formula (I), wherein R<1> represents C1-6 alkyl and R<2> and R<3> are, independently of each other, hydrogen or C1-6 alkyl. Said chloropyrimidines are produced from the corresponding 4- hydroxy-2- mercaptopyrimidines which are reacted with a C1-6 alkyl halide to produce the corresponding 2- (alkylthio) -4- hydroxypyrimidine. The reaction product is subsequently chlorinated with phosgene. The 2- (alkylthio) -4- chlorpyrimidines are intermediate products in the synthesis of fungicides and beta-blockers.

专利号:WO-2013163159-A2
优先权日:2012-04-24
标 题:Design and synthesis of novel inhibitors of isoprenoid biosynthesis

专利号:SU-1738088-A3
优先权日:1987-07-17
标 题 :Method for synthesis of cis-derivatives of n-(3-hydroxy-4-piperidinyl)-benzamide

专利号:WO-2018218006-A1
优先权日:2017-05-24
标 题 :Enzymatic dna synthesis using the terminal transferase activity of template-dependent dna polymerases