CAS: 5051-62-7; 2-(2,6-Dichlorobenzylidene)Hydrazine-1-Carboximidamide

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CAS号83-38-5 2,6-二氯苯甲醛 | CAS号79-17-4 氨基胍盐酸盐

📜胍诺沙苄置于cytochrome B5,Mitochondrial Amidoxime Reducing Component 1,Nadh Cytochrome B5 Reductase,还原型辅酶ⅰ体系中,化学反应生成 胍那苄
参考文献:The Fourth Molybdenum Containing Enzyme Marc: Cloning And Involvement In The Activation Of N-Hydroxylated Prodrugs
标题:The Fourth Molybdenum Containing Enzyme Marc: Cloning And Involvement In The Activation Of N-Hydroxylated Prodrugs
摘要:The Recently Discovered Mammalian Molybdoprotein Marc1 Is Capable Of Reducing N-Hydroxylated Compounds. Upon Reconstitution With Cytochrome B(5) And B5 Reductase,Benzamidoxime,Pentamidine,And Diminazene Amidoximes,N-Hydroxymelagatran,Guanoxabenz,And N-Hydroxydebrisoquine Are Efficiently Reduced. These Substances Are Amidoxime/n-Hydroxyguanidine Prodrugs,Leading To Improved Bioavailability Compared To The Active Amidines/guanidines. Thus,The Recombinant Enzyme Allows Prediction About In Vivo Reduction Of N-Hydroxylated Prodrugs. Furthermore,The Prodrug Principle Is Not Dependent On Cytochrome P450 Enzymes.
DOI:10.1021/jm8010417

专利信息

专利号:US-2008090885-A1
优先权日:2006-10-12
标题:Preparation of losartan 5-carboxylic acid and use thereof
发明人：CHEN LIQIN; LI JIAN; SHEN YINGZHONG
权利人:CHEN LIQIN; LI JIAN; SHEN YINGZHONG
摘要:A method for synthesis of losartan 5-carboxylic acid (EXP-3174).

专利号:US-RE41998-E
优先权日:1990-02-26
标题 :Compositions and methods of treatment of sympathetically maintained pain
发明人：CAMPBELL JAMES N
权利人:ARCLON THERAPEUTICS INC
摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

专利号:US-4656291-A
优先权日:1985-03-15
标 题 :Process for producing amidine sulfonic acids
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:US-4781866-A
优先权日:1985-03-15
标题 :Process for producing amidine sulfonic acid intermediates for guanidines
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

专利号:US-4851094-A
优先权日:1985-03-15
标 题:Process for producing amidine sulfonic acid intermediates for guanidines
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): (III) (II) with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.