CAS: 501120-42-9; 4-Ethoxy-3-(2-Methyl-7-Oxo-3-Propyl-4,7-Dihydro-2H-Pyrazolo[4,3-D]Pyrimidin-5-yl)Benzenesulfonyl Chloride

该化合物是一种专门化的氯杀螨醇衍生物,用作合成药用活性化合物的关键中间体,其结构特征,包括经过修改的氯杀螨醇组和全氟化碳,使得目标分子设计能够精确地发挥功能,该化合物在药用化学中对于开发具有定制特性的类似物,如强化选择性或改进的药用植物基因学特别宝贵,作为全氟辛烷磺酸的高度再活性有助于在受控条件下有效衍生,产品通常在惰性大气中处理,因为它对湿度敏感,适当的储存和处理程序对于保持稳定性和确保合成应用的一致性能至关重要.

英文名称4-Ethoxy-3-(2-Methyl-7-Oxo-3-Propyl-4,7-Dihydro-2H-Pyrazolo[4,3-D]Pyrimidin-5-yl)Benzenesulfonyl Chloride
中文名称去甲基哌嗪基异西地那非磺酰氯
IUPAC名称4-Ethoxy-3-(2-methyl-7-oxo-3-propyl-4,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride
CAS编号501120-42-9
分子式:C17H19ClN4O4S分子量:410.88
产品CID: 1488578
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: XPOJLYGSFUUUDG-UHFFFAOYSA-N
InChI=1S/C17H19ClN4O4S/c1-4-6-12-14-15(21-22(12)3)17(23)20-16(19-14)11-9-10(27(18,24)25)7-8-13(11)26-5-2/h7-9H,4-6H2,1-3H3,(H,19,20,23)
计算化学: 氢键受体数6.0氢键供体数1.0可旋转键数6.0

MSDS等安全信息

上下游产品

5-(2-ethoxyphenyl)-2-methyl-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-7-one 2-ethoxybenzoic acid ethyl 3-butyrylpyruvate 4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide

合成工艺路线路线简述

📜2-乙氧基苯甲酸置于氯磺酸,氯化亚砜,Ppa体系中,化学反应 7.0H,反应生成去甲基哌嗪基异西地那非磺酰氯
参考文献:Synthesis And Properties Of Iso Viagra. A 2‐methyl‐2 H ‐pyrazolo[4,3‐ D]Pyrirnidin‐7‐one Isomer Of Viagra ®
标题:Synthesis And Properties Of Iso Viagra. A 2‐methyl‐2 H ‐pyrazolo[4,3‐ D]Pyrirnidin‐7‐one Isomer Of Viagra ®
摘要:Abstractthe Synthesis And Spectral Properties (Ir,Ms,NMR) Of A Substituted 2‐methyl‐2H‐pyrazolo[4,3‐d]‐pyrimidin‐7‐one (3),An Isomer Of Viagra®,Are Described. The Key Synthon,4‐amino‐1‐methyl‐5‐propyl‐3‐pyrazolecarboxamide (7),Is Prepared Via The Reaction Of Ethyl 2,4‐dioxoheptanoate With Methylhydrazine,Followed By Cyclization,Nitration,Amidation,And Nitro Group Reduction. Interaction Of 7 With 2‐ethoxyben‐zoyl Chloride Yielded The Respective Bis‐amide (8) Which Was Cyclized In Polyphosphoric Acid To The Corresponding Pyrazolo[4,3‐d]Pyrimidin‐7‐one Derivative 9. Chlorosulfonylation Of 9,And Subsequent Treatment With 1‐methylpiperazine Furnished Iso Viagra (3).
DOI:10.1002/jhet.5570390532