CAS: 443882-99-3; 2-Chloro-1-((3-Fluorobenzyl)Oxy)-4-Nitrobenzene

上下游产品

2-氯-4-硝基苯酚 2-Chloro-4-Nitrophenol 619-08-9

3-氯-4-氟硝基苯置于sodium Hydride体系中,用 N,N-二甲基甲酰胺,Dmf (N,N-Dimethyl-Formamide) 作为反应溶剂,化学反应 4.58H,以83%的收率获得产物3-氯-4-(3-氟苄氧基)硝基苯
参考文献:Cyanoguanidines And Cyanoamidines As Erbb2 And Egfr Inhibitors
标题:Cyanoguanidines And Cyanoamidines As Erbb2 And Egfr Inhibitors
摘要:本文披露了在治疗过度增殖性疾病中有用的氰胍嘧啶和氰胍胺喹唑啉衍生物.还披露了在哺乳动物中治疗过度增殖性疾病的方法.

专利信息

专利号:WO-2013080218-A1
优先权日:2011-11-28
标 题 :Novel intermediates and process for the preparation of lapatinib and its pharmaceutically acceptable salts
发明人：LAHIRI SASWATA; GUPTA NITIN; SINGH HEMANT KUMAR; HANDA VISHAL; SANGHANI SUNIL
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention discloses novel intermediates and processes for the synthesis of Lapatinib and its pharmaceutically acceptable salts thereof.

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates

专利号:CN-114315595-A
优先权日:2021-11-30
标题:Preparation method of carbon-supported iron-based catalyst and synthesis application of anti-cancer inhibitor intermediate thereof

专利号:CN-116655599-A
优先权日:2023-05-17
标题:Synthesis and application of a class of EGFR allosteric inhibitors

专利号:CN-118652239-A
优先权日:2024-05-29
标题 :Synthesis and application of EGFR allosteric inhibitors