CAS: 33229-89-9; N,N-Dimethylglycine Ethyl Ester

该化合物是一种二甲基氨基乙酸的多元酯衍生物,通常用作有机合成和制药生产中的关键中间体,其反应式酯类和三级安咪性功能使其对制备四氨化合物,催化剂和活性药物成分(API)具有价值.该化合物在极地有机溶剂中表现出良好的溶解性,便于其在一系列反应中使用,包括电极和凝聚.在标准条件下的稳定性和高效的再活动有助于其在精细化学生产中的用途.乙基乙酸在合成生物活性分子和特殊化学品中所发挥的作用特别突出.

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77385-90-1 2491-06-7 1118-68-9

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上下游产品

CAS号50-00-0 甲醛 | CAS号459-73-4 2-胺基乙酸乙酯 | CAS号105-39-5 氯乙酸乙酯 | CAS号124-40-3 二甲胺 | CAS号64-17-5 乙醇 | CAS号2491-06-7 N,N-二甲基甘氨酸盐酸盐 | CAS号102244-73-5 meso-2,3-Di(dim... | CAS号3032-11-9 BETAINE ETHYL E... | CAS号1007879-60-8 ethyl 2-(dimeth... | CAS号102827-29-2 2-(dimethylamin... | CAS号1118-68-9 N,N-二甲基甘氨酸 | CAS号6947-68-8 2H-Indol-2-one,... | CAS号71172-40-2 ethyl 2-(cyano-... | CAS号74347-10-7 1-dimethylamino... | CAS号66917-63-3 ethyl 2-(dimeth... | CAS号55-85-6 二甲氨基乙酰肼 | CAS号6309-83-7 4-dimethylamino...

合成工艺路线路线简述

    📜N,N-二甲基草酸乙酯置于三苯基硼烷,甲基苯基硅烷体系中,用 二氯甲烷-D2 作为反应溶剂,化学反应 24.0H,反应生成 N,N-二甲氨基乙酸乙酯
    参考文献:叔胺化学选择性还原成三苯硼烷催化的胺
    标题:叔胺化学选择性还原成三苯硼烷催化的胺
    摘要:发现三苯硼烷(bph 3)在温和的条件下,在酮,酯和亚胺的存在下,具有高化学选择性,可以催化叔丁基酰胺与氢硅烷的还原,从而反应生成胺.还原n,N-二甲基丙烯酰胺以提供α-甲硅烷基酰胺.初步研究表明,Bph 3催化的氢化硅烷化可能与亲电子性更高的b(c 6 F 5)3催化的氢化机理不同.
    DOI:10.1002/anie.201605236

    海关参考信息

    专利信息


    专利号:US-3721650-A
    优先权日:1971-03-22
    标题 :Reactive hydroxyalkyl-onium catalysts for synthesis of polyoxazolidones
    发明人：D ALELIO G
    权利人:ALELIO G D
    摘要:A PROCESS FOR PREPARING POLYOXAZOLIDONES IS PROVIDED IN WHICH A POLYEPOXIDE IS REACTED WITH A POLYISOCYANATE IN THE PRESENCE OF CHEMICALLY REACTIVE HYDROXYALKYL-ONIUM CATALYSTS, SELECTED FROM THE CLASS OF AMMONIUM AND PHOSPHONIUM HALIDES HAVING AT LEAST TWO HYDROXYALKYL GROUPS. NOVEL POLYMERS ARE OBTAINED WHEN THESE NEW CATALYSTS CONTAINING TWO OR MORE HYDROXY GROUPS ARE CONDENSED WITH POLYISOCYANATES.

    专利号:US-10822377-B2
    优先权日:2015-03-04
    标 题:Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase
    发明人：LEE RICHARD E; ZHAO YING; JIUYU LIU
    权利人:ST JUDE CHILDRENS RES HOSPITAL
    摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:CN-119552087-A
    优先权日:2024-12-02
    标 题:Synthesis method of dialkylamino alcohol

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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
    [参考文献]: Tzi-Yi Wu, Et Al. Physicochemical Properties Of Glycine-Based Ionic Liquid [quatgly-Oet][etoso(3)] (2-Ethoxy-1-Ethyl-1,1-Dimethyl-2-Oxoethanaminium Ethyl Sulfate) And Its Binary Mixtures With Poly(Ethylene Glycol) (M(W) = 200) At Various Temperatures. Int J Mol Sci. 2011;12(12):8750-72.

    合成参考文献


    摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 381.
    摘要:Ipaktschi, J.; Saidi, M. R., Science of Synthesis Knowledge Updates, (2012) 4, 410.
    摘要:Marsden, S. P., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 586.
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