📜1,1,3-Tribromononane置于sodium Ethanolate,Potassium Iodide体系中,化学反应生成2-壬烯醛 参考文献:Kharasch; Jensen; Urry,Journal Of The American Chemical Society,1947,Vol. 69,P. 1104 标题:Kharasch; Jensen; Urry,Journal Of The American Chemical Society,1947,Vol. 69,P. 1104
专利号:US-2005004225-A1 优先权日:2003-04-16 标题:Oxidoreductase inhibitors and methods of screening and using thereof 发明人:BALENDIRAN GANESARATNAM K 摘要:The present invention relates to 1) the design and synthesis of analogs to glutathione conjugates which bind to or interact with aldose reductase (AR) through unique conformations that are distinctly different from the substrates and inhibitors of AR which are members of sugar metabolism; 2) the screening of the analogs to identify those that interact with or inhibit or enhance the activity of AR; and 3) the use of AR ligands, AR inhibitors (AR antagonsits) or AR enhancer (AR agonists) in the detection of AR activity, the modulation of AR activity, and the treatment of conditions in a subject in need of modulating AR activity. Such conditions include but not limited to cardiovascular disease, diabetes, artheriosclerosis, cancer, neoplasm, obesity, cataract, retinopathy, keratopathy, nephropathy, neurosis, thrombosis, faulty union of corneal injury and neuropathy. Examples of the treatment include the use of fibrates as AR inhibitors to treat these conditions.
专利号:US-7838053-B2 优先权日:2004-03-11 标题:Barley for production of flavor-stable beverage 发明人:BREDDAM KLAUS; OLSEN OLE; SKADHAUGE BIRGITTE; LOK FINN; KNUDSEN SOEREN; BECH LENE MOELSKOV 权利人:CARLSBERG AS 摘要:According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which-through further enzymatic or spontaneous reactions-may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off flavors, even after prolonged storage of the beverage.
专利号:US-2025109161-A1 优先权日:2021-11-30 标 题 :Heme, compositions and method of synthesis thereof 发明人:LEONG TAI WEI DAVID; ANG WEE HAN; LEONG LAI PENG; THAM JING RUI 权利人:NAT UNIV SINGAPORE 摘要:The present disclosure concerns heme and methods of synthesis thereof. The present disclosure also concerns to compositions and products thereof. The heme composition comprises heme at about 0.05% w/w to about 1% w/w relative to the heme composition and an antioxidant at about 0.25% w/w to about 5% w/w relative to the heme composition, wherein the heme is derived from protoporphyrin IX extracted from a plant, algal, bacterial and/or animal source.
专利号:US-9363959-B2 优先权日:2008-12-30 标 题 :Barley with reduced lipoxygenase activity and beverage prepared therefrom 发明人:SKADHAUGE BIRGITTE; LOK FINN; BREDDAM KLAUS; OLSEN OLE; BECH LETTE MØLSKOV; KNUDSEN SØREN 权利人:SKADHAUGE BIRGITTE; LOK FINN; BREDDAM KLAUS; OLSEN OLE; BECH LETTE MØLSKOV; KNUDSEN SØREN; CARLSBERG BREWERIES AS; HEINEKEN SUPPLY CHAIN BV 摘要:According to the invention, there is provided barley with total loss of functional lipoxygenase (LOX)-1 and LOX-2 enzymes, and plant products produced thereof, such as malt manufactured by using barley kernels defective in the synthesis of the fatty acid-dioxygenating enzymes LOX-1 and LOX-2. Said enzymes account for the principal activities related to dioxygenation of linoleic acid into 9- and 13-hydroperoxy octadecadienoic acid, respectively. 9-Hydroperoxy octadecadienoic acid represents a LOX pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal (T2N). The invention enables brewers to produce a beer having insignificant levels of stale, T2N-specific off-flavors, even after prolonged storage of the beverage.
专利号:CZ-310054-B6 优先权日:2022-07-06 标 题:The method of homolytic and heterolytic breaking of bonds in molecules of gases and liquids with the primary release of binding energy, the use of this energy to change the internal geometric architecture of some molecules leading to the synthesis of new chemical compounds and devices for its implementation
专利号:CZ-2022301-A3 优先权日:2022-07-06 标 题 :The method of homolytic and heterolytic breaking of bonds in molecules of gases and liquids with the primary release of binding energy, the use of this energy to change the internal geometric architecture of some molecules leading to the synthesis of new chemical compounds and devices for its implementation
参考标题:Synthesis Of α,β-Unsaturated Aldehydes By Means Of 3-Methoxy-1-Phenylthio-1-Propene 作者:Makoto Wada,Hideo Nakamura,Takeo Taguchi,Hisashi Takei |发布日期:1977.4.5 摘要:Obtained By The Reaction Of 1-Phenylthio-2,3-Epoxypropane (1) With Sodium Hydride In Tetrahydrofuran (Thf) And Successive Treatment With Methyl Iodide, Was Lithiated With Lithium Diisopropylamide At −78°C. The Lithio Derivative Reacted With Alkyl Halides Regioselectively At The α-Position Of Sulfur Atom, And Hydrolysis Of The Products At Room Temperature In The Presence Of Mercuric Chloride Afforded The