CAS: 23680-31-1; Boc-Ser(Bzl)-Oh

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Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于三丁基氧化锡体系中,用 氯仿 用作溶剂,化学反应 120.0H,以12%的收率获得n-Boc-O-苄基-L-丝氨酸
参考文献:N-保护的氨基酸和二肽的苯甲酰基,苄基和甲基酯的选择性脱保护以及与双(三丁基锡)氧化物连接的树脂的n-保护的氨基酸苄基酯的脱保护
标题:N-保护的氨基酸和二肽的苯甲酰基,苄基和甲基酯的选择性脱保护以及与双(三丁基锡)氧化物连接的树脂的n-保护的氨基酸苄基酯的脱保护
摘要:各种n-α-B°C,N-α-Cbz或n,N-二甲基氨基保护的氨基酸和二肽的苯甲酸酯,甲基和苄基酯以及与wang和pam树脂连接的n-α保护的氨基酸的酯具有在非质子溶剂中用双(三丁基锡)氧化物有效地和化学选择性地裂解该化合物,从而以非常好的收率获得相应的羧酸.此外,已经证明在脱保护过程中不存在外消旋作用.该方法的一个限制是不稳定ñ-îμ-Fmoc基团的氨基酸酯8和10,ñ-α-的fmoc-大号β-丙氨酸连接于王氏树脂23和cbz基保护基团在ñ-α-的boc-N-Iμ-Cbz-大号赖氨酸苄基和甲酯(5和7),分别与ñ-α-Cbz-大号-Alanyl-大号丙氨酸甲酯19的情况下ñ-在α-保护的二肽中,没有游离氨基酸的迹象表明该肽键不受影响.
Doi:10.1039/p19960000995

专利信息

专利号:US-3953416-A
优先权日:1971-12-20
标 题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
发明人：FOLKERS KARL; CURRIE BRUCE L; CHANG JAW-KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
权利人:FOLKERS KARL; CURRIE BRUCE L; CHANG JAW KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.

专利号:US-4301045-A
优先权日:1977-05-02
标 题:Synthesis of peptides
发明人：KAISER EMIL; COLESCOTT ROBERT L
权利人:ARMOUR PHARMA
摘要:Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing Pro-Asp-CH2- or Pro-Asn-CH2- at one end of an amino acid chain, being the resin and Pro, Asp and Asn being the residues of the amino acids proline, aspartic acid and asparagine; and processes for the preparation of such resin peptides.

专利号:US-2006167268-A1
优先权日:2002-04-09
标 题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.