CAS: 17094-01-8; (S)-2-Amino-6-(2-Hydroxypropanoyl)-7,8-Dihydropteridin-4(3H)-One

1-(2-Amino-4-Cyclohexyloxy-7,8-Dihydropteridin-6-yl)-2S-2-(Methoxymethoxy)Propan-1-One置于盐酸,Sodium Hydroxide体系中,用 水 用作溶剂,化学反应生成L-墨蝶呤
参考文献:Method For Producing Sepiapterin And Tetrahydrolactoylpterin
标题:Method For Producing Sepiapterin And Tetrahydrolactoylpterin

专利信息

专利号:US-5401844-A
优先权日:1983-04-11
标 题 :Regulation of enzymes which utilize tetrahydrobiopterin or tetrahydrofolate cofactors with 6,6-disubstituted-tetrahydropteridines
发明人：AYLING JUNE E; BAILEY STEVEN W
权利人:UNIV SOUTH ALABAMA
摘要:6-[2'-Amino-2',2'-disubstituted-ethylamino]-pyrimidines of the structure: ##STR1## in which X=H, NH 2 or NO 2 , which are novel intermediates in the synthesis of quinoid 6,6-disubstituted-dihydro- and 6,6-disubstituted-tetrahydro-pteridines, are claimed.

专利号:US-6153615-A
优先权日:1991-12-26
标 题 :Blocking induction of tetrahydrobioterin to block induction of nitric oxide synthesis
发明人：GROSS STEVEN S
权利人:CORNELL RES FOUNDATION INC
摘要:Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonists are administered to inhibit nitric oxide synthesis from arginine in vascular cells in a subject in need of such inhibition (e.g., for prophylactic or curative effect for endotoxin- or cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension). The tetrahydrobiopterin synthesis antagonist may be administered with α 1 -adrenergic agonist or with nitric oxide synthase inhibitor. The tetrahydrobiopterin synthesis antagonists are also administered to attenuate inflammation caused by induced nitric oxide production in immune cells. Unwanted counterproductive or side effects can be eliminated or ameliorated by administration additionally of levodopa with or without carbidopa and L-5-hydroxytryptophane.

专利号:US-6274581-B1
优先权日:1991-12-26
标 题 :Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
发明人：GROSS STEVEN S
权利人:CORNELL RES FOUNDATION INC
摘要:Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonist are administered to inhibit nitric oxide synthesis from arginine in vascular smooth muscle cells in a subject in need of such inhibition (e.g. for prophylactic or curative effect for cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension).

专利号:US-6844343-B1
优先权日:1999-09-17
标 题 :N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
发明人：PFLEIDERER WOLFGANG; SCHMIDT HARALD; FROEHLICH LOTHAR; KOTSONIS PETER; TAGHAVI-MOGHADAM SHAHRIYAR
权利人:VASOPHARM BIOTECH GMBH
摘要:Compounds of formula (I), where preferably: A=a bridge of partial formula (II) or (III), R<1 >and R<2>=independently (substituted) alkyl, aryl or aralkyl, or together form a heterocycle, R<3>=H, -CO-Alkyl, or -CO-Aryl, R<4>=Aryl, -CO-O-Aryl or -CO-Aryl and R<5>=H, are potent inhibitors of NO-synthase and are suitable as pharmaceutical agents of prophylaxis and treatment of disease states associates with a disturbed NO metabolism.

专利号:JP-H06316576-A
优先权日:1983-04-11
标题 :Synthesis of 6,6-di-substituted dihydropteridine

专利号:US-5877176-A
优先权日:1991-12-26
标题 :Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis