CAS: 158440-71-2; Irofulven

上下游产品

5'-羟基-2',5',7'-三甲基螺[环丙烷-1,6'-茚]-4'-酮 (-)-Acylfulvene 125392-76-9
隐陡头菌素; 隐杯伞素; 月亮霉素 Illudin S 1149-99-1

📜隐陡头菌素; 隐杯伞素; 月亮霉素置于硫酸体系中,用 四氢呋喃 用作溶剂,化学反应 48.0H,反应生成(-)-伊洛福芬
参考文献:Synthesis Of [3H]-Illudin S,[3H]-Acylfulvene,[3H] & [14C]-Hydroxymethylacylfulvene (Mgi 114)
标题:Synthesis Of [3H]-Illudin S,[3H]-Acylfulvene,[3H] & [14C]-Hydroxymethylacylfulvene (Mgi 114)
摘要:Tritiated Derivatives Of The Toxic Sesquiterpene Illudin S (1) Have Been Prepared By Fermentation Of Omphalotus Illudens In The Presence Of [h-3]-Sodium Acetate. [h-3]-Illudin S Was Converted To Antitumor [h-3]-Acylfulvene (4) By Treatment With Dilute Sulfuric Acid. Antitumor [c-14]-Hydroxymethylacylfulvene (5) Was Best Prepared By Reacting Acylfulvene With [c-14]-Paraformaldehyde In Dilute Sulfuric Acid.
Doi:10.1002/(Sici)1099-1344(199804)41:4<279::Aid-Jlcr86>3.0.Co;2-J

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2024352049-A1
优先权日:2023-04-19
标 题:Direct synthesis of alkoxysilanes using copper-aluminum alloy catalysts
发明人：LEWIS KENRICK MARTIN; MEREIGH ABELLARD
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:An improved catalyzed reaction of silicon metal with alcohol is provided for the formation of alkoxysilanes, particularly trialkoxysilanes. The Direct Synthesis reaction of silicon metal and alcohol employs a catalytically effective amount of a copper-aluminum alloy as a catalyst precursor and further benefits from an effective catalyst-promoting amount of a catalyst promoter.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-8598153-B2
优先权日:2006-09-22
标题 :Method of treatment using fatty acid synthesis inhibitors
发明人：SINGH SHEO B; TOTA MICHAEL R; WANG JUN
权利人:SINGH SHEO B; TOTA MICHAEL R; WANG JUN; MERCK SHARP & DOHME
摘要:The present invention relates to natural products that possess fatty acid synthesis inhibitor activity and can be used to treat and prevent diseases such as obesity, cancer, diabetes, fungal infections, Mycobacterium tuberculosis infections, malarial infections and other apicomplexan protozoal diseases.